Desbuquois syndrome

ABC transporters ATP sensitive Potassium channels ABC-family proteins mediated transport Ion homeostasis Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia +2 more

Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) +4 more

Riboflavin metabolism Metabolic pathways Lysosome Osteoclast differentiation Rheumatoid arthritis Vitamin B2 (riboflavin) metabolism +3 more

ATP-dependent chromatin remodeling Rap1 signaling pathway Phagosome Apoptosis Hippo signaling pathway Focal adhesion Adherens junction Tight junction Platelet activation Neutrophil extracellular trap formation Leukocyte transendothelial migration Thermogenesis Regulation of actin cytoskeleton Motor proteins Cytoskeleton in muscle cells Thyroid hormone signaling pathway Oxytocin signaling pathway Gastric acid secretion Amyotrophic lateral sclerosis Bacterial invasion of epithelial cells Vibrio cholerae infection Pathogenic Escherichia coli infection Shigellosis Salmonella infection Yersinia infection Influenza A Proteoglycans in cancer Hepatocellular carcinoma Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Viral myocarditis Fluid shear stress and atherosclerosis Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Cell-extracellular matrix interactions B-WICH complex positively regulates rRNA expression RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins MAP2K and MAPK activation UCH proteinases DNA Damage Recognition in GG-NER Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis Signaling downstream of RAS mutants FCGR3A-mediated phagocytosis +54 more

Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells Fluid shear stress and atherosclerosis +2 more

Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

Other glycan degradation Lysosome Neutrophil degranulation

Ether lipid metabolism Metabolic pathways Peroxisome Plasmalogen biosynthesis Peroxisomal protein import +2 more

Apoptosis Necroptosis

N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG12 causes ALG12-CDG (CDG-1g) +2 more

N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG3 causes ALG3-CDG (CDG-1d) +2 more

N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) +2 more

Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 +4 more

Thiamine metabolism Folate biosynthesis Metabolic pathways Biosynthesis of cofactors Post-translational modification: synthesis of GPI-anchored proteins +2 more

Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex +8 more

Miscellaneous transport and binding events

Efferocytosis Stimuli-sensing channels

NOD-like receptor signaling pathway Uptake and function of anthrax toxins

Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells Regulation of actin cytoskeleton Cushing syndrome Alzheimer disease Pathways of neurodegeneration - multiple diseases Human papillomavirus infection Pathways in cancer MicroRNAs in cancer Colorectal cancer Endometrial cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer +13 more

COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic

Rho GTPase cycle

ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known +2 more

Glycosaminoglycan degradation Metabolic pathways Lysosome Glycosphingolipid metabolism The activation of arylsulfatases CS/DS degradation MPS VI - Maroteaux-Lamy syndrome Neutrophil degranulation +5 more

Glycosphingolipid metabolism The activation of arylsulfatases

Oxidative phosphorylation Metabolic pathways Lysosome Phagosome Synaptic vesicle cycle Collecting duct acid secretion Vibrio cholerae infection Epithelial cell signaling in Helicobacter pylori infection Tuberculosis Human papillomavirus infection Rheumatoid arthritis ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Ion channel transport +12 more

Fanconi anemia pathway Cell cycle p53 signaling pathway Cellular senescence Human papillomavirus infection Human T-cell leukemia virus 1 infection Human immunodeficiency virus 1 infection Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint +13 more

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways A tetrasaccharide linker sequence is required for GAG synthesis Defective B3GALT6 causes EDSP2 and SEMDJL1 +2 more

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways A tetrasaccharide linker sequence is required for GAG synthesis Defective B3GAT3 causes JDSSDHD +2 more

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways A tetrasaccharide linker sequence is required for GAG synthesis Defective B4GALT7 causes EDS, progeroid type +2 more

Cytoskeleton in muscle cells A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1 +9 more

Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils HDL assembly +2 more

Cytokine-cytokine receptor interaction TGF-beta signaling pathway Hippo signaling pathway Pathways in cancer Basal cell carcinoma Signaling by BMP Molecules associated with elastic fibres Transcriptional regulation by RUNX2 +5 more

Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway Axon guidance Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells Fluid shear stress and atherosclerosis Signaling by BMP +5 more

Sulfur metabolism Metabolic pathways Phosphatidylinositol signaling system Cytosolic sulfonation of small molecules +1 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway ErbB signaling pathway Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway FoxO signaling pathway mTOR signaling pathway Vascular smooth muscle contraction Focal adhesion Natural killer cell mediated cytotoxicity Long-term potentiation Neurotrophin signaling pathway Serotonergic synapse Long-term depression Regulation of actin cytoskeleton Insulin signaling pathway Progesterone-mediated oocyte maturation Parathyroid hormone synthesis, secretion and action Cushing syndrome Alzheimer disease Pathways of neurodegeneration - multiple diseases Alcoholism Hepatitis C Hepatitis B Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Melanoma Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Spry regulation of FGF signaling Frs2-mediated activation RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants +52 more

RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter

NF-kappa B signaling pathway Osteoclast differentiation Platelet activation B cell receptor signaling pathway Fc epsilon RI signaling pathway Epstein-Barr virus infection Primary immunodeficiency ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated Ca+2 mobilization G alpha (q) signalling events G alpha (12/13) signalling events MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate WASPs and WAVEs G beta:gamma signalling through BTK FCGR3A-mediated phagocytosis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers +17 more

Oocyte meiosis Ubiquitin mediated proteolysis Cellular senescence Wnt signaling pathway Hedgehog signaling pathway Hippo signaling pathway Circadian rhythm Shigellosis Human immunodeficiency virus 1 infection Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Deactivation of the beta-catenin transactivating complex Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation +24 more

Nitrogen metabolism Metabolic pathways Proximal tubule bicarbonate reclamation Collecting duct acid secretion Gastric acid secretion Pancreatic secretion Bile secretion Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide +7 more

Purine metabolism Pyrimidine metabolism Metabolic pathways Nucleotide metabolism Neutrophil degranulation +2 more