Desbuquois syndrome

Lysosome Renin-angiotensin system Glycosphingolipid metabolism MHC class II antigen presentation Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation +4 more

Lysosome Apoptosis Osteoclast differentiation Toll-like receptor signaling pathway Rheumatoid arthritis Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Trafficking and processing of endosomal TLR MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes +8 more

Ubiquitin mediated proteolysis XBP1(S) activates chaperone genes Neddylation Antigen processing: Ubiquitination & Proteasome degradation +1 more

Retinol metabolism Metabolic pathways Vitamins RA biosynthesis pathway Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) +2 more

Steroid biosynthesis Metabolic pathways Parathyroid hormone synthesis, secretion and action Tuberculosis Vitamin D (calciferol) metabolism Vitamins Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) +4 more

Steroid biosynthesis Metabolic pathways Vitamin D (calciferol) metabolism Vitamins Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) +2 more

Non-integrin membrane-ECM interactions

Steroid biosynthesis Metabolic pathways Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol +1 more

Pyrimidine metabolism Metabolic pathways Biosynthesis of cofactors Pyrimidine biosynthesis +1 more

Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation Pathways in cancer Chemical carcinogenesis - receptor activation Breast cancer +3 more

Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation Pathways in cancer Chemical carcinogenesis - receptor activation Breast cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus +9 more

Signaling pathways regulating pluripotency of stem cells

ECM-receptor interaction ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation +1 more

DNA replication Removal of the Flap Intermediate from the C-strand HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation Removal of the Flap Intermediate G2/M DNA damage checkpoint +9 more

Cysteine and methionine metabolism Metabolic pathways Efferocytosis MicroRNAs in cancer PRC2 methylates histones and DNA RMTs methylate histone arginines +3 more

Factors involved in megakaryocyte development and platelet production

ATP-dependent chromatin remodeling

N-Glycan biosynthesis Metabolic pathways Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u) +3 more

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Metabolic pathways Dermatan sulfate biosynthesis

mTOR signaling pathway Wnt signaling pathway Notch signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells Melanogenesis Cushing syndrome Alzheimer disease Pathways of neurodegeneration - multiple diseases Human papillomavirus infection Pathways in cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer WNT mediated activation of DVL PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping +18 more

mTOR signaling pathway Wnt signaling pathway Notch signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells Melanogenesis Cushing syndrome Alzheimer disease Pathways of neurodegeneration - multiple diseases Human papillomavirus infection Pathways in cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer WNT mediated activation of DVL PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping +18 more

Phagosome Motor proteins Vasopressin-regulated water reabsorption Salmonella infection Hedgehog 'off' state Intraflagellar transport +3 more

Motor proteins Vasopressin-regulated water reabsorption Salmonella infection Intraflagellar transport +1 more

Steroid biosynthesis Metabolic pathways Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol +1 more

cAMP signaling pathway HIF-1 signaling pathway Neuroactive ligand-receptor interaction Vascular smooth muscle contraction TNF signaling pathway Melanogenesis Renin secretion Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer Hypertrophic cardiomyopathy Fluid shear stress and atherosclerosis Peptide ligand-binding receptors G alpha (q) signalling events +11 more

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Vascular smooth muscle contraction Renin secretion Pathways in cancer Peptide ligand-binding receptors G alpha (q) signalling events +6 more

Ribosome biogenesis in eukaryotes

Axon guidance EPH-Ephrin signaling EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells +2 more

Spliceosome mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway

Mitophagy - animal Autophagy - animal Protein processing in endoplasmic reticulum Apoptosis Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Hepatitis C Measles Herpes simplex virus 1 infection Lipid and atherosclerosis PERK regulates gene expression +12 more

Nucleocytoplasmic transport mRNA surveillance pathway Spliceosome ISG15 antiviral mechanism Transport of Mature mRNA derived from an Intron-Containing Transcript Deadenylation of mRNA mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +7 more

Purine metabolism Pyrimidine metabolism Starch and sucrose metabolism Riboflavin metabolism Nicotinate and nicotinamide metabolism Pantothenate and CoA biosynthesis Metabolic pathways Nucleotide metabolism Vitamin B2 (riboflavin) metabolism Vitamin B5 (pantothenate) metabolism +7 more

Other types of O-glycan biosynthesis

Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway HIF-1 signaling pathway FoxO signaling pathway Cell cycle Wnt signaling pathway Notch signaling pathway TGF-beta signaling pathway Adherens junction JAK-STAT signaling pathway Long-term potentiation Melanogenesis Thyroid hormone signaling pathway Glucagon signaling pathway Growth hormone synthesis, secretion and action Huntington disease Tuberculosis Hepatitis B Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Viral carcinogenesis MicroRNAs in cancer Renal cell carcinoma Prostate cancer Regulation of gene expression by Hypoxia-inducible Factor RORA activates gene expression Polo-like kinase mediated events Pre-NOTCH Transcription and Translation PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production HATs acetylate histones Attenuation phase Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Circadian Clock B-WICH complex positively regulates rRNA expression CD209 (DC-SIGN) signaling Metalloprotease DUBs Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NGF-stimulated transcription TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Transcriptional regulation of granulopoiesis Regulation of FOXO transcriptional activity by acetylation +66 more

Oncogene Induced Senescence

Cell cycle Establishment of Sister Chromatid Cohesion

Hedgehog signaling pathway Hedgehog 'on' state Activation of SMO

Hedgehog signaling pathway Hedgehog 'on' state Activation of SMO