Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
CROHN DISEASE	C0010346 MESH:D003424	FMNL2	Causal	—	Disgenet	Cytoskeleton in muscle cells RHO GTPases Activate Formins
		ADIPOQ	Unknown	21829567	CTD	PPAR signaling pathway Hormone signaling AMPK signaling pathway +7 more
		ATG16L1	Unknown	17435756 18438406	CTD	Autophagy - other Autophagy - animal NOD-like receptor signaling pathway +2 more
		ATG4C	Unknown	36038634	CTD	Autophagy - other Autophagy - animal Macroautophagy
		BACH2	Unknown	21102463	CTD	—
		CCL2	Unknown	21829567	CTD	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +18 more
		CCNY	Unknown	18438405	CTD	—
		CCR7	Unknown	36038634	CTD	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +2 more
		CIBAR2	Unknown	17435756	CTD	—
		CRP	Unknown	11339241	CTD	Classical antibody-mediated complement activation
		DENND1B	Unknown	21102463	CTD	RAB GEFs exchange GTP for GDP on RABs
		DNMT3A	Unknown	21102463	CTD	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		DOK2	Unknown	36038634	CTD	Tie2 Signaling RET signaling
		ERAP2	Unknown	21102463	CTD	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
		ERCC2	Unknown	—	Disgenet	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		FN1	Unknown	19751734	CTD	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +33 more
		FPR2	Unknown	21659618	CTD	Neuroactive ligand-receptor interaction Neutrophil extracellular trap formation Staphylococcus aureus infection +4 more
		FUT2	Unknown	21102463	CTD	Glycosphingolipid biosynthesis - lacto and neolacto series Glycosphingolipid biosynthesis - globo and isoglobo series Metabolic pathways +2 more
		GPBAR1	Unknown	23566200	CTD	Class A/1 (Rhodopsin-like receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
		HGFAC	Unknown	36038634	CTD	MET Receptor Activation
		HLA-DRB1	Unknown	25559196	CTD	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HSPA1L	Unknown	—	Disgenet	Spliceosome MAPK signaling pathway Protein processing in endoplasmic reticulum +13 more
		IFNG	Unknown	21829567	CTD	Proteasome Cytokine-cytokine receptor interaction HIF-1 signaling pathway +33 more
		IGF1	Unknown	19751734	CTD	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +35 more
		IL10	Unknown	21102463	CTD	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor FoxO signaling pathway +25 more
		IL10RA	Unknown	36038634	CTD	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor JAK-STAT signaling pathway +4 more
		IL12B	Unknown	18438406	CTD	Cytokine-cytokine receptor interaction Toll-like receptor signaling pathway RIG-I-like receptor signaling pathway +26 more
		IL23R	Unknown	17068223 17435756 18438406	CTD	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +4 more
		IL2RA	Unknown	21102463	CTD	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Endocytosis +12 more
		IL6	Unknown	10700533 21829567	CTD	EGFR tyrosine kinase inhibitor resistance Antifolate resistance Cytokine-cytokine receptor interaction +59 more
		IRGM	Unknown	17554261 18438406 19165925 21278745	CTD	NOD-like receptor signaling pathway Toxoplasmosis
		LEP	Unknown	21829567	CTD	Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling +7 more
		MST1	Unknown	18438406	CTD	Calcium signaling pathway Signaling by MST1
		MTHFR	Unknown	28002332	CTD	One carbon pool by folate Metabolic pathways Antifolate resistance +2 more
		MYO5B	Unknown	—	Disgenet	Motor proteins Pathogenic Escherichia coli infection Vasopressin regulates renal water homeostasis via Aquaporins
		NCF4	Unknown	17435756	CTD	Phagosome Osteoclast differentiation Neutrophil extracellular trap formation +10 more
		NKX2-3	Unknown	17554261 18438405 18438406	CTD	—
		NLRP3	Unknown	19098911	CTD	Necroptosis NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway +12 more
		NOD2	Unknown	11385576 11385577 11528384 17435756 17568627 18371140 18438406 19467619 37156999	CTD, Disgenet	NOD-like receptor signaling pathway TNF signaling pathway Tuberculosis +7 more
		NR1H4	Unknown	21829567	CTD	Bile secretion Recycling of bile acids and salts Synthesis of bile acids and bile salts +6 more
		PDLIM5	Unknown	36038634	CTD	Cytoskeleton in muscle cells
		PHOX2B	Unknown	17435756	CTD	—
		PPARA	Unknown	21829567	CTD	PPAR signaling pathway cAMP signaling pathway Adipocytokine signaling pathway +16 more
		PPARG	Unknown	21829567	CTD	PPAR signaling pathway Efferocytosis AMPK signaling pathway +13 more
		PRKCQ	Unknown	—	Disgenet	NF-kappa B signaling pathway Autophagy - animal Vascular smooth muscle contraction +14 more
		PTAFR	Unknown	36038634	CTD	Calcium signaling pathway Neuroactive ligand-receptor interaction Staphylococcus aureus infection +5 more
		PTPN2	Unknown	17554261	CTD	JAK-STAT signaling pathway Negative regulation of MET activity Regulation of IFNG signaling +1 more
		RELA	Unknown	36038634	CTD	Antifolate resistance MAPK signaling pathway Ras signaling pathway +95 more
		SDF2L1	Unknown	36038634	CTD	—
		SLC11A1	Unknown	16059695	CTD	Lysosome ROS and RNS production in phagocytes Metal ion SLC transporters +2 more
CROHN'S DISEASE	EFO_0000384	ATG16L1	Unknown	17435756 17554300 18587394 20570966 21102463 22412388 22936669 23128233 26192919 26301688 26974007 28067908 33686288 37156999 37523193	GWAS catalog	Autophagy - other Autophagy - animal NOD-like receptor signaling pathway +2 more
		ATG4C	Unknown	37156999	GWAS catalog	Autophagy - other Autophagy - animal Macroautophagy
		BACH2	Unknown	21102463 23128233 26192919 26974007 28067908 37156999	GWAS catalog	—
		CCL2	Unknown	21102463 22412388 23128233 26192919 26974007 28067908 37156999 37262302 38616254	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +18 more
		CCNY	Unknown	37262302	GWAS catalog	—
		CCR7	Unknown	37156999	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +2 more
		DENND1B	Unknown	21102463 23128233 26192919 26974007 28067908 37156999	GWAS catalog	RAB GEFs exchange GTP for GDP on RABs
		DNMT3A	Unknown	21102463 26974007 28506689 37156999	GWAS catalog	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		ERAP2	Unknown	21102463 23128233 26192919 26301688 26974007 28067908 37156999	GWAS catalog	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
		FUT2	Unknown	20570966 21102463 23128233 26192919 26301688 26974007 28067908 37156999	GWAS catalog	Glycosphingolipid biosynthesis - lacto and neolacto series Glycosphingolipid biosynthesis - globo and isoglobo series Metabolic pathways +2 more
		GPBAR1	Unknown	26192919	GWAS catalog	Class A/1 (Rhodopsin-like receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
		HGFAC	Unknown	26192919 37156999	GWAS catalog	MET Receptor Activation
		HLA-DRB1	Unknown	18758464 21699788 23850713 26891255 37156999	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		IL10	Unknown	21102463 23128233 26192919 26301688 26974007 28008999 28067908 33608531 37156999	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor FoxO signaling pathway +25 more
		IL23R	Unknown	17435756 17447842 17554300 18587394 18758464 20570966 21102463 22293688 22412388 22936669 23128233 23850713 26192919 26301688 26974007 28008999 28067908 30500874 32581322 33608531 33686288 37156999 39024449 39789286	GWAS catalog	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +4 more
		IL2RA	Unknown	21102463 23128233 26192919 26301688 26974007 28067908 37156999 37262302	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Endocytosis +12 more
		IRGM	Unknown	17554261 17554300 18587394 21102463 23128233 26192919 26974007 28067908 33686288 37156999 37523193	GWAS catalog	NOD-like receptor signaling pathway Toxoplasmosis
		MST1	Unknown	18587394 21102463 23128233 26192919 26974007 28067908	GWAS catalog	Calcium signaling pathway Signaling by MST1
		NCF4	Unknown	27569725 28067908 37156999 37523193	GWAS catalog	Phagosome Osteoclast differentiation Neutrophil extracellular trap formation +10 more
		NKX2-3	Unknown	26301688 33686288 37262302 37523193	GWAS catalog	—
		NOD2	Unknown	17068223 17435756 17447842 17554300 17684544 17804789 18587394 18758464 20570966 21102463 22412388 22936669 23128233 26974007 28067908 28506689 33608531 35512355 37156999 39789286	GWAS catalog	NOD-like receptor signaling pathway TNF signaling pathway Tuberculosis +7 more
		PRKCQ	Unknown	26974007	GWAS catalog	NF-kappa B signaling pathway Autophagy - animal Vascular smooth muscle contraction +14 more
		PTPN2	Unknown	17554261 17554300 18587394 21102463 23128233 25489960 26192919 26974007 28067908 37156999 37262302	GWAS catalog	JAK-STAT signaling pathway Negative regulation of MET activity Regulation of IFNG signaling +1 more
		RELA	Unknown	26192919	GWAS catalog	Antifolate resistance MAPK signaling pathway Ras signaling pathway +95 more
CROHNS DISEASE OF LARGE BOWEL	C0156147	ADIPOQ	Unknown	—	Disgenet	PPAR signaling pathway Hormone signaling AMPK signaling pathway +7 more
		ATG16L1	Unknown	—	Disgenet	Autophagy - other Autophagy - animal NOD-like receptor signaling pathway +2 more
		ATG4C	Unknown	—	Disgenet	Autophagy - other Autophagy - animal Macroautophagy
		BACH2	Unknown	—	Disgenet	—
		CCL2	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +18 more
		CCNY	Unknown	—	Disgenet	—
		CCR7	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +2 more
		CIBAR2	Unknown	—	Disgenet	—
		CRP	Unknown	—	Disgenet	Classical antibody-mediated complement activation
		DENND1B	Unknown	—	Disgenet	RAB GEFs exchange GTP for GDP on RABs
		DNMT3A	Unknown	—	Disgenet	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		DOK2	Unknown	—	Disgenet	Tie2 Signaling RET signaling
		FN1	Unknown	—	Disgenet	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +33 more
		FPR2	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Neutrophil extracellular trap formation Staphylococcus aureus infection +4 more
		FUT2	Unknown	—	Disgenet	Glycosphingolipid biosynthesis - lacto and neolacto series Glycosphingolipid biosynthesis - globo and isoglobo series Metabolic pathways +2 more
		GPBAR1	Unknown	—	Disgenet	Class A/1 (Rhodopsin-like receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
		HGFAC	Unknown	—	Disgenet	MET Receptor Activation
		HLA-DRB1	Unknown	—	Disgenet	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		IFNG	Unknown	—	Disgenet	Proteasome Cytokine-cytokine receptor interaction HIF-1 signaling pathway +33 more
		IGF1	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +35 more
		IL10	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor FoxO signaling pathway +25 more
		IL10RA	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor JAK-STAT signaling pathway +4 more
		IL12B	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Toll-like receptor signaling pathway RIG-I-like receptor signaling pathway +26 more
		IL23R	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +4 more
		IL2RA	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Endocytosis +12 more
		IL6	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Antifolate resistance Cytokine-cytokine receptor interaction +59 more
		IRGM	Unknown	—	Disgenet	NOD-like receptor signaling pathway Toxoplasmosis
		LEP	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling +7 more
		MST1	Unknown	—	Disgenet	Calcium signaling pathway Signaling by MST1
		MTHFR	Unknown	—	Disgenet	One carbon pool by folate Metabolic pathways Antifolate resistance +2 more
		NCF4	Unknown	—	Disgenet	Phagosome Osteoclast differentiation Neutrophil extracellular trap formation +10 more
		NLRP3	Unknown	—	Disgenet	Necroptosis NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway +12 more
		NOD2	Unknown	—	Disgenet	NOD-like receptor signaling pathway TNF signaling pathway Tuberculosis +7 more
		NR1H4	Unknown	—	Disgenet	Bile secretion Recycling of bile acids and salts Synthesis of bile acids and bile salts +6 more
		PDLIM5	Unknown	—	Disgenet	Cytoskeleton in muscle cells
		PHOX2B	Unknown	—	Disgenet	—
		PPARA	Unknown	—	Disgenet	PPAR signaling pathway cAMP signaling pathway Adipocytokine signaling pathway +16 more
		PPARG	Unknown	—	Disgenet	PPAR signaling pathway Efferocytosis AMPK signaling pathway +13 more
		PTAFR	Unknown	—	Disgenet	Calcium signaling pathway Neuroactive ligand-receptor interaction Staphylococcus aureus infection +5 more
		PTPN2	Unknown	—	Disgenet	JAK-STAT signaling pathway Negative regulation of MET activity Regulation of IFNG signaling +1 more
		RELA	Unknown	—	Disgenet	Antifolate resistance MAPK signaling pathway Ras signaling pathway +95 more
		SDF2L1	Unknown	—	Disgenet	—
		SLC11A1	Unknown	—	Disgenet	Lysosome ROS and RNS production in phagocytes Metal ion SLC transporters +2 more

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Crohn disease

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