Complex neurodevelopmental disorder

Ubiquitin mediated proteolysis Rho GTPase cycle

Circadian rhythm

Polycomb repressive complex RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Transcriptional Regulation by E2F6

Apoptotic cleavage of cellular proteins SUMOylation of chromatin organization proteins

Lysine degradation Metabolic pathways PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function +1 more

Glutamatergic synapse Neurexins and neuroligins

Glutamatergic synapse Neurexins and neuroligins

Bicarbonate transporters

mTOR signaling pathway Central carbon metabolism in cancer Basigin interactions Amino acid transport across the plasma membrane Tryptophan catabolism +2 more

ATP-dependent chromatin remodeling B-WICH complex positively regulates rRNA expression Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Deposition of new CENPA-containing nucleosomes at the centromere +1 more

Deactivation of the beta-catenin transactivating complex

Various types of N-glycan biosynthesis Other types of O-glycan biosynthesis Mannose type O-glycan biosynthesis Glycosaminoglycan biosynthesis - keratan sulfate Glycosphingolipid biosynthesis - lacto and neolacto series Metabolic pathways Keratan sulfate biosynthesis Defective ST3GAL3 causes MCT12 and EIEE15 Sialic acid metabolism Lewis blood group biosynthesis Termination of O-glycan biosynthesis +8 more

Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression +4 more

Wnt signaling pathway RORA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events +11 more

Wnt signaling pathway Hippo signaling pathway Adherens junction Melanogenesis Cushing syndrome Alcoholic liver disease Salmonella infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Colorectal cancer Endometrial cancer Prostate cancer Thyroid cancer Basal cell carcinoma Acute myeloid leukemia Breast cancer Hepatocellular carcinoma Gastric cancer Arrhythmogenic right ventricular cardiomyopathy Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes TCF7L2 mutants don't bind CTBP Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling +26 more

Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux +12 more

Ubiquitin mediated proteolysis Antigen processing: Ubiquitination & Proteasome degradation

tRNA modification in the nucleus and cytosol

Ubiquitin mediated proteolysis

Synaptic vesicle cycle

Cell cycle Oocyte meiosis PI3K-Akt signaling pathway Hippo signaling pathway Hepatitis C Hepatitis B Viral carcinogenesis Activation of BAD and translocation to mitochondria Deactivation of the beta-catenin transactivating complex Rap1 signalling GP1b-IX-V activation signalling KSRP (KHSRP) binds and destabilizes mRNA Interleukin-3, Interleukin-5 and GM-CSF signaling RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NOTCH4 Activation and Transmission of Signal to the Nucleus Regulation of localization of FOXO transcription factors +15 more

ATP-dependent chromatin remodeling Polycomb repressive complex UCH proteinases DNA Damage Recognition in GG-NER TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Estrogen-dependent gene expression +3 more

Wnt signaling pathway Regulation of FZD by ubiquitination