Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
COLORECTAL CANCER	MONDO_0005575 114500 MONDO:0005575	CMSS1	Unknown	32887889	GWAS catalog	—
		CNIH1	Unknown	38538606	GWAS catalog	COPII-mediated vesicle transport Cargo concentration in the ER
		CNPY1	Unknown	29228715	GWAS catalog	—
		CNTN3	Unknown	38538606	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		CNTN5	Unknown	32514122 34671089 38589358 38872215	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		COL22A1	Unknown	38411962	GWAS catalog	Protein digestion and absorption Collagen biosynthesis and modifying enzymes Collagen chain trimerization
		COL4A2	Unknown	30510241 31089142 34594039 36539618 37340002 38538606	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +20 more
		COL5A1	Unknown	38538606	GWAS catalog	Cytoskeleton in muscle cells Protein digestion and absorption Collagen degradation +10 more
		COPS5	Unknown	38538606	GWAS catalog	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis +1 more
		COX14	Unknown	38872215	GWAS catalog	Thermogenesis TP53 Regulates Metabolic Genes Respiratory electron transport
		COX7A2L	Unknown	31826910	GWAS catalog	Oxidative phosphorylation Metabolic pathways Cardiac muscle contraction +12 more
		CPS1	Unknown	38538606	GWAS catalog	Arginine biosynthesis Alanine, aspartate and glutamate metabolism Nitrogen metabolism +4 more
		CPT1B	Unknown	35512400	GWAS catalog	Fatty acid degradation Fatty acid metabolism PPAR signaling pathway +10 more
		CPVL	Unknown	29228715	GWAS catalog	—
		CRTC3	Unknown	29228715 31089142 36539618	GWAS catalog	Human T-cell leukemia virus 1 infection Transcriptional activation of mitochondrial biogenesis Circadian Clock
		CSMD1	Unknown	38411962 38538606	GWAS catalog	—
		CSRNP3	Unknown	26621817	GWAS catalog	—
		CTIF	Unknown	38538606 38872215	GWAS catalog	—
		CUBN	Unknown	25990418	GWAS catalog	Vitamin digestion and absorption Cobalamin (Cbl, vitamin B12) transport and metabolism Vitamin D (calciferol) metabolism +3 more
		CUX2	Unknown	38872215	GWAS catalog	—
		CWC22	Unknown	25866641	GWAS catalog	mRNA Splicing - Major Pathway
		CXCR5	Unknown	36539618	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +2 more
		CYB5R1	Unknown	38538606	GWAS catalog	Biosynthesis of various nucleotide sugars Platelet degranulation Erythrocytes take up carbon dioxide and release oxygen
		CYBRD1	Unknown	32887889	GWAS catalog	Mineral absorption Iron uptake and transport
		CYP17A1	Unknown	26965516	GWAS catalog	Steroid hormone biosynthesis Metabolic pathways Ovarian steroidogenesis +6 more
		CYP24A1	Unknown	26766742	GWAS catalog	Steroid biosynthesis Metabolic pathways Parathyroid hormone synthesis, secretion and action +4 more
		CYRIB	Unknown	23266556	GWAS catalog	Regulation of actin cytoskeleton Platelet degranulation
		DCAF12	Unknown	34594039 36539618 38872215	GWAS catalog	—
		DCAF4	Unknown	34290314	GWAS catalog	Neddylation
		DCBLD1	Unknown	23266556 26151821 35512400 36539618 38872215	GWAS catalog	—
		DENND2B	Unknown	38538606	GWAS catalog	RAB GEFs exchange GTP for GDP on RABs
		DENND5B	Unknown	30529582 36539618 38411962	GWAS catalog	RAB GEFs exchange GTP for GDP on RABs
		DGKH	Unknown	31826910 38411962	GWAS catalog	Glycerolipid metabolism Glycerophospholipid metabolism Metabolic pathways +4 more
		DHX15	Unknown	38538606	GWAS catalog	Spliceosome mRNA Splicing - Major Pathway
		DHX35	Unknown	29698419	GWAS catalog	—
		DHX36	Unknown	38538606	GWAS catalog	RNA degradation DEx/H-box helicases activate type I IFN and inflammatory cytokines production
		DIP2B	Unknown	20972440 23300701 25990418 38408508 38872215	GWAS catalog	—
		DIP2C	Unknown	25866641	GWAS catalog	—
		DIPK2A	Unknown	38538606	GWAS catalog	—
		DISC1	Unknown	38411962	GWAS catalog	—
		DISP1	Unknown	35512400	GWAS catalog	Hedgehog signaling pathway
		DLC1	Unknown	—	ClinVar, HPO	Rho GTPase cycle
		DLD	Unknown	38749303	GWAS catalog	Glycolysis / Gluconeogenesis Citrate cycle (TCA cycle) Glycine, serine and threonine metabolism +20 more
		DLEU7	Unknown	38411962	GWAS catalog	—
		DLGAP1	Unknown	36539618	GWAS catalog	Glutamatergic synapse Neurexins and neuroligins
		DLGAP2	Unknown	36077729	GWAS catalog	—
		DLGAP4	Unknown	34290314	GWAS catalog	Neurexins and neuroligins
		DNAJC1	Unknown	32887889	GWAS catalog	Protein processing in endoplasmic reticulum
		DOCK3	Unknown	29228715	GWAS catalog	NTRK2 activates RAC1 Factors involved in megakaryocyte development and platelet production
		DPEP1	Unknown	34290314	GWAS catalog	Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification LTC4-CYSLTR mediated IL4 production
COLORECTAL CARCINOMA	EFO_1001951	CNTN5	Unknown	38589358	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
RECTUM CANCER	EFO_1000657	CWC22	Unknown	25866641	GWAS catalog	mRNA Splicing - Major Pathway
		DIP2C	Unknown	25866641	GWAS catalog	—
		DLC1	Unknown	32887889	GWAS catalog	Rho GTPase cycle
		DLGAP2	Unknown	36077729	GWAS catalog	—

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Colorectal cancer

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