Subtype of: Central nervous system cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
central nervous system primitive neuroectodermal neoplasm	MONDO_0000640	GSK3B	Unknown	22722829	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Chemokine signaling pathway +59 more
		H3-3A	Unknown	22820256 23354654	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +18 more
		H4C9	Unknown	25642631	Open Targets	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +33 more
		HERPUD1	Unknown	25642631	Open Targets	Protein processing in endoplasmic reticulum ATF4 activates genes in response to endoplasmic reticulum stress
		HGF	Unknown	25642631 22820256 22722829	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +29 more
		HIP1	Unknown	25642631	Open Targets	Huntington disease Pathways of neurodegeneration - multiple diseases Clathrin-mediated endocytosis
		HLA-A	Unknown	22832583	Open Targets	Endocytosis Phagosome Cellular senescence +25 more
		HNF1A	Unknown	22820256	Open Targets	Maturity onset diabetes of the young
		HOOK3	Unknown	22722829	Open Targets	Motor proteins
		HOXA13	Unknown	22820256	Open Targets	—
		HOXA9	Unknown	25642631	Open Targets	Transcriptional misregulation in cancer
		HOXC11	Unknown	25642631	Open Targets	—
		HSP90AA1	Unknown	25642631	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +56 more
		HSP90AB1	Unknown	25642631	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +26 more
		IDH1	Unknown	22820256 33193845 21643842 22588899 19411854 21378543	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IGF2BP2	Unknown	22820256	Open Targets	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
		IKZF1	Unknown	25642631 22722829	Open Targets	—
		IKZF3	Unknown	25642631 22722829	Open Targets	—
		IL21R	Unknown	22722829	Open Targets	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +2 more
		IRS4	Unknown	25642631	Open Targets	cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling +11 more
		ISX	Unknown	25642631	Open Targets	—
		ITGAV	Unknown	25642631	Open Targets	Hormone signaling Phagosome Efferocytosis +26 more
		ITK	Unknown	22722829	Open Targets	Chemokine signaling pathway T cell receptor signaling pathway Leukocyte transendothelial migration +2 more
		JAK1	Unknown	25642631 32291395 22722829	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAK2	Unknown	25642631 22722829	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAK3	Unknown	25642631 22722829	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		JUN	Unknown	25642631	Open Targets	Endocrine resistance MAPK signaling pathway ErbB signaling pathway +63 more
		KAT6A	Unknown	25642631 22722829	Open Targets	Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation
		KAT6B	Unknown	25642631 22722829	Open Targets	HATs acetylate histones
		KCNJ5	Unknown	25642631	Open Targets	Circadian entrainment Retrograde endocannabinoid signaling Serotonergic synapse +8 more
		KDM5A	Unknown	25642631 22820256 32291395 22722829	Open Targets	HDMs demethylate histones
		KDM5C	Unknown	25642631 22820256	Open Targets	HDMs demethylate histones
		KDM6A	Unknown	22820256 23184418 22722829 25642631 28481359 22832583	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KDR	Unknown	25642631	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		KIAA1549	Unknown	25642631	Open Targets	Signaling by BRAF and RAF fusions
		KLF4	Unknown	25642631 22820256	Open Targets	Signaling pathways regulating pluripotency of stem cells Chemical carcinogenesis - receptor activation Synthesis, secretion, and deacylation of Ghrelin +1 more
		KMT2A	Unknown	25642631 21163964	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	25642631 22820256 22722829 25030029 22832583	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	22820256 31351799 22722829 33020650 21163964 25642631 22832583	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KNL1	Unknown	25642631	Open Targets	Cell cycle Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		KNSTRN	Unknown	22820256	Open Targets	—
		KRAS	Unknown	1314130	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		KTN1	Unknown	25642631	Open Targets	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
		LARP4B	Unknown	25642631	Open Targets	—
		LATS1	Unknown	25642631	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LATS2	Unknown	25642631	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LCP1	Unknown	25642631	Open Targets	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
		LEF1	Unknown	22722829	Open Targets	Wnt signaling pathway Hippo signaling pathway Adherens junction +24 more
		LHFPL6	Unknown	22722829	Open Targets	—
		LIFR	Unknown	25642631	Open Targets	Cytokine-cytokine receptor interaction Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway +2 more

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Central nervous system primitive neuroectodermal neoplasm

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