Subtype of: Central nervous system cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
central nervous system primitive neuroectodermal neoplasm	MONDO_0000640	TCF7L2	Unknown	22832583 22722829	Open Targets	Wnt signaling pathway Hippo signaling pathway Adherens junction +26 more
		TEC	Unknown	25642631	Open Targets	Osteoclast differentiation T cell receptor signaling pathway Signaling by SCF-KIT +2 more
		TENT5C	Unknown	25642631	Open Targets	—
		TET1	Unknown	25642631 22832583	Open Targets	—
		TET2	Unknown	25642631	Open Targets	—
		TFE3	Unknown	25642631	Open Targets	Mitophagy - animal Transcriptional misregulation in cancer Renal cell carcinoma
		TFEB	Unknown	25642631	Open Targets	Calcium signaling pathway Mitophagy - animal
		TFPT	Unknown	25642631	Open Targets	ATP-dependent chromatin remodeling UCH proteinases DNA Damage Recognition in GG-NER
		THRAP3	Unknown	25642631	Open Targets	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation
		TNC	Unknown	25642631	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +6 more
		TNFAIP3	Unknown	22820256	Open Targets	NF-kappa B signaling pathway Necroptosis NOD-like receptor signaling pathway +10 more
		TNRC18	Unknown	25642631 22820256 22832583	Open Targets	—
		TOP1	Unknown	25642631 22722829	Open Targets	SUMOylation of DNA replication proteins
		TP53	Unknown	22820256 26822237 28481359 1933879 8396224 21378543 15450401 9615731 22722829 25642631 33020650 9546059 1873817 11051241 8640736 14969745 7923211 8180965 21060032 22832583	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TP63	Unknown	25642631 22820256 22722829	Open Targets	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TPM3	Unknown	25642631	Open Targets	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +7 more
		TPR	Unknown	25642631 26822237 22820256 22832583	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Pathways in cancer +27 more
		TRAF7	Unknown	25642631 22820256	Open Targets	Antigen processing: Ubiquitination & Proteasome degradation
		TRIM24	Unknown	25642631 22820256 22832583	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF fusions
		TRIM33	Unknown	25642631 22820256	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity
		TRIP11	Unknown	25642631 22832583	Open Targets	Intraflagellar transport Intra-Golgi traffic
		TRRAP	Unknown	25642631 22820256 22832583	Open Targets	ATP-dependent chromatin remodeling Human T-cell leukemia virus 1 infection Formation of the beta-catenin:TCF transactivating complex +1 more
		TSC1	Unknown	25642631	Open Targets	Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway +15 more
		TSC2	Unknown	25642631 22832583	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		U2AF1	Unknown	22820256	Open Targets	Spliceosome Shigellosis Transport of Mature mRNA derived from an Intron-Containing Transcript +3 more
		UBR5	Unknown	25642631	Open Targets	Ubiquitin mediated proteolysis
		USP44	Unknown	25642631	Open Targets	Ub-specific processing proteases
		USP6	Unknown	25642631	Open Targets	—
		USP8	Unknown	25642631 22832583	Open Targets	Mitophagy - animal Endocytosis Cushing syndrome +4 more
		USP9X	Unknown	25642631 22820256	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes +2 more
		VAV1	Unknown	25642631	Open Targets	Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway +30 more
		WAS	Unknown	22820256	Open Targets	Chemokine signaling pathway Adherens junction Tight junction +7 more
		WNK2	Unknown	25642631	Open Targets	Parathyroid hormone synthesis, secretion and action Stimuli-sensing channels
		WRN	Unknown	25642631 22820256 22832583	Open Targets	Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins +9 more
		WT1	Unknown	25642631	Open Targets	Transcriptional misregulation in cancer
		WWTR1	Unknown	22722829	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo +5 more
		YAP1	Unknown	25642631 21163964 22722829	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Nuclear signaling by ERBB4 +5 more
		ZBTB16	Unknown	22722829	Open Targets	Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia +2 more
		ZEB1	Unknown	25642631	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Prostate cancer +1 more
		ZFHX3	Unknown	25642631 22722829	Open Targets	Signaling pathways regulating pluripotency of stem cells RUNX3 regulates CDKN1A transcription
		ZMYM2	Unknown	25642631 22820256	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease
		ZMYM3	Unknown	25642631 22832583 22820256 22722829	Open Targets	—
		ZNF331	Unknown	22722829	Open Targets	Generic Transcription Pathway
		ZNF521	Unknown	25642631	Open Targets	—
		ZNRF3	Unknown	25642631	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination
		ZRSR2	Unknown	25642631 22722829	Open Targets	mRNA Splicing - Minor Pathway

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Central nervous system primitive neuroectodermal neoplasm

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