Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
cecum adenocarcinoma	MONDO_0006028	BCL10	Unknown	29316426 28481359	Open Targets	NF-kappa B signaling pathway C-type lectin receptor signaling pathway T cell receptor signaling pathway +8 more
		BCL11A	Unknown	25344691 29844865	Open Targets	—
		BCL11B	Unknown	25344691	Open Targets	Transcriptional misregulation in cancer
		BCL2	Unknown	38725616 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +46 more
		BCL2L12	Unknown	38725616 25344691	Open Targets	—
		BCL3	Unknown	25344691	Open Targets	C-type lectin receptor signaling pathway TNF signaling pathway
		BCL6	Unknown	28481359 25344691	Open Targets	FoxO signaling pathway Transcriptional misregulation in cancer Chemical carcinogenesis - receptor activation +3 more
		BCL9	Unknown	22810696	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCL9L	Unknown	22810696 26336987 25344691	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCLAF1	Unknown	22810696 25344691	Open Targets	—
		BCOR	Unknown	28481359 29316426 25344691	Open Targets	Polycomb repressive complex
		BCORL1	Unknown	30239619 26336987 25344691	Open Targets	Polycomb repressive complex
		BCR	Unknown	30239619 26336987 29844865	Open Targets	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
		BIRC3	Unknown	22810696 28481359	Open Targets	Platinum drug resistance NF-kappa B signaling pathway Ubiquitin mediated proteolysis +23 more
		BIRC6	Unknown	22810696 26336987 25344691 38725616	Open Targets	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species
		BLM	Unknown	22810696 29316426 28481359	Open Targets	Homologous recombination Fanconi anemia pathway Processive synthesis on the C-strand of the telomere +10 more
		BMP5	Unknown	22810696 25344691	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Hippo signaling pathway
		BMPR1A	Unknown	22810696 28481359	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway +4 more
		BRAF	Unknown	22810696 21901162 26650777 19378335 28481359 23049789 21704278 29316426 19679059 26336987 22438407 28978093 14688025 21520036 25344691 18759827 20473912 21646616	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA1	Unknown	38725616 28481359 26336987 25344691	Open Targets	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		BRCA2	Unknown	22810696 28481359 29316426 25344691 29967250	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		BRD3	Unknown	26336987 25344691	Open Targets	—
		BRD4	Unknown	26336987 28481359	Open Targets	—
		BRIP1	Unknown	22810696 28481359 29316426 25344691 29844865	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +8 more
		BTK	Unknown	22810696 26336987 28481359	Open Targets	NF-kappa B signaling pathway Osteoclast differentiation Platelet activation +17 more
		BUB1B	Unknown	22810696	Open Targets	Cell cycle Human T-cell leukemia virus 1 infection Inactivation of APC/C via direct inhibition of the APC/C complex +9 more
		CACNA1D	Unknown	26336987 25344691 26764183	Open Targets	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +35 more
		CAMTA1	Unknown	26336987 25344691	Open Targets	—
		CARD11	Unknown	29316426 26336987 28481359	Open Targets	NF-kappa B signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway +4 more
		CASP3	Unknown	25344691	Open Targets	Platinum drug resistance MAPK signaling pathway p53 signaling pathway +53 more
		CASP8	Unknown	28978093 29316426 28481359	Open Targets	Platinum drug resistance p53 signaling pathway Apoptosis +53 more
		CASP9	Unknown	26336987	Open Targets	Platinum drug resistance p53 signaling pathway PI3K-Akt signaling pathway +39 more
		CBFA2T3	Unknown	38725616 25344691	Open Targets	—
		CBFB	Unknown	22810696 29316426 28481359	Open Targets	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Transcriptional regulation by RUNX2 RUNX1 regulates estrogen receptor mediated transcription +20 more
		CBL	Unknown	30239619 28481359	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +22 more
		CBLB	Unknown	22810696 25344691	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +5 more
		CCND1	Unknown	28481359	Open Targets	Endocrine resistance FoxO signaling pathway Cell cycle +58 more
		CCND2	Unknown	29316426 28481359	Open Targets	FoxO signaling pathway Cell cycle p53 signaling pathway +18 more
		CCND3	Unknown	25344691	Open Targets	Cell cycle p53 signaling pathway PI3K-Akt signaling pathway +17 more
		CCNE1	Unknown	28481359	Open Targets	Cell cycle Oocyte meiosis p53 signaling pathway +24 more
		CCR4	Unknown	25344691	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +4 more
		CCR7	Unknown	22810696 25344691	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +2 more
		CD209	Unknown	22810696 25344691	Open Targets	Virion - Human immunodeficiency virus Virion - Flavivirus and Alphavirus Virion - Ebolavirus, Lyssavirus and Morbillivirus +7 more
		CD274	Unknown	22810696 28481359	Open Targets	Cell adhesion molecules PD-L1 expression and PD-1 checkpoint pathway in cancer PD-1 signaling
		CD28	Unknown	22810696	Open Targets	Cell adhesion molecules T cell receptor signaling pathway Intestinal immune network for IgA production +16 more
		CD79A	Unknown	22810696 29316426 28481359	Open Targets	B cell receptor signaling pathway Primary immunodeficiency CD22 mediated BCR regulation +1 more
		CD79B	Unknown	28481359	Open Targets	B cell receptor signaling pathway CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
		CDC73	Unknown	22810696 28481359 38725616	Open Targets	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state +3 more
		CDH1	Unknown	22810696 29316426 28481359 29967250	Open Targets	Rap1 signaling pathway Apelin signaling pathway Hippo signaling pathway +15 more
		CDH10	Unknown	22810696 25344691	Open Targets	Adherens junctions interactions

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Cecum adenocarcinoma

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