Subtype of: Breast cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
breast phyllodes tumor	MONDO_0021047	MAP2K4	Unknown	28481359 26832993	Open Targets	MAPK signaling pathway ErbB signaling pathway Toll-like receptor signaling pathway +21 more
		MAP3K1	Unknown	26437033	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MED12	Unknown	34597441 25855048 34091389 27806318 30467240 26856273 26437033 27566247 26860948 26018969 28721388 25593300 29066183 27255162 26093648 37706238 35365682 26355235 29315289 25865354 26832993 26109290 25931199 28481359	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MET	Unknown	34091389	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MSH2	Unknown	25593300	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MTOR	Unknown	28481359 26832993	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MUC16	Unknown	26437033	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		NACA	Unknown	26437033	Open Targets	Parathyroid hormone synthesis, secretion and action
		NF1	Unknown	28481359 25593300 26832993 26437033	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NF2	Unknown	28481359 26832993	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Tight junction +2 more
		NOTCH1	Unknown	36271373	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NRAS	Unknown	28481359 23895135 26832993	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		PAX5	Unknown	26437033	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PIK3CA	Unknown	28481359 19706770 27255162 26832993 26437033	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3R1	Unknown	27566247 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PLEC	Unknown	26437033	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		POLQ	Unknown	26437033	Open Targets	HDR through MMEJ (alt-NHEJ)
		PPP6C	Unknown	26832993	Open Targets	COPII-mediated vesicle transport
		PRDM1	Unknown	26832993	Open Targets	Regulation of TP53 Expression
		PTEN	Unknown	26832993 36271373 27255162 26437033 27566247 28481359	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPN11	Unknown	26832993	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		RARA	Unknown	28481359 26437033	Open Targets	Th17 cell differentiation Estrogen signaling pathway Pathways in cancer +6 more
		RB1	Unknown	35365682 26832993 25593300 29066183 27255162 26437033 34091389 23895135 28481359 37706238	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RBM15	Unknown	26437033	Open Targets	—
		RET	Unknown	26832993 28648934	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		ROS1	Unknown	26437033	Open Targets	—
		SETD2	Unknown	28481359 27255162 26832993 28721388 26437033	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SF3B1	Unknown	28481359 26832993 26437033	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		SMAD4	Unknown	28648934 26437033	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SMARCA4	Unknown	26832993	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SS18L1	Unknown	26437033	Open Targets	ATP-dependent chromatin remodeling Transcriptional misregulation in cancer
		STAT3	Unknown	26437033	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway HIF-1 signaling pathway +53 more
		TBX3	Unknown	26832993	Open Targets	Signaling pathways regulating pluripotency of stem cells
		TCF7L2	Unknown	26437033	Open Targets	Wnt signaling pathway Hippo signaling pathway Adherens junction +26 more
		TET1	Unknown	28481359	Open Targets	—
		TET2	Unknown	25593300	Open Targets	—
		TGFBR2	Unknown	28481359	Open Targets	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +28 more
		TNFRSF14	Unknown	37706238	Open Targets	Virion - Herpesvirus Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +3 more
		TRAF7	Unknown	27255162 26832993	Open Targets	Antigen processing: Ubiquitination & Proteasome degradation
		TSC2	Unknown	25593300 27255162	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		VHL	Unknown	27255162	Open Targets	HIF-1 signaling pathway Ubiquitin mediated proteolysis Pathways in cancer +5 more

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Breast phyllodes tumor

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