Breast cancer

Endocytosis Rho GTPase cycle

NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Vascular smooth muscle contraction Axon guidance Platelet activation C-type lectin receptor signaling pathway Regulation of actin cytoskeleton Pathogenic Escherichia coli infection Yersinia infection Tuberculosis Human cytomegalovirus infection Pathways in cancer Proteoglycans in cancer NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse +12 more

Melanogenesis

Ion transport by P-type ATPases

Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases

Miscellaneous transport and binding events

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance ErbB signaling pathway Ras signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway Autophagy - animal PI3K-Akt signaling pathway Apoptosis VEGF signaling pathway Focal adhesion Neurotrophin signaling pathway Insulin signaling pathway Thyroid hormone signaling pathway Alzheimer disease Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Human papillomavirus infection Herpes simplex virus 1 infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Prostate cancer Melanoma Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Hepatocellular carcinoma Lipid and atherosclerosis Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK Constitutive Signaling by AKT1 E17K in Cancer +44 more

Regulation of TP53 Activity through Association with Co-factors

Endocrine resistance

Neuroactive ligand-receptor interaction Vascular smooth muscle contraction G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production +2 more

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Cell adhesion molecules Adherens junctions interactions Myogenesis

Endocrine resistance Platinum drug resistance Cell cycle p53 signaling pathway Cellular senescence Cushing syndrome Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Pathways in cancer Viral carcinogenesis MicroRNAs in cancer Pancreatic cancer Glioma Melanoma Bladder cancer Chronic myeloid leukemia Non-small cell lung cancer Hepatocellular carcinoma Apoptotic factor-mediated response Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors Regulation of TP53 Degradation Cyclin D associated events in G1 Stabilization of p53 Transcriptional Regulation by VENTX Regulation of RUNX3 expression and activity Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function Evasion of Oncogene Induced Senescence Due to p14ARF Defects Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects +33 more

Sphingolipid metabolism Metabolic pathways Sphingolipid signaling pathway Sphingolipid de novo biosynthesis +1 more

ATP-dependent chromatin remodeling HDACs deacetylate histones SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription +3 more

Viral life cycle - HIV-1 Virion - Hepatitis viruses Endocytosis Necroptosis Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Sealing of the nuclear envelope (NE) by ESCRT-III +6 more

Cell adhesion molecules

Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Signaling by FGFR1 in disease AURKA Activation by TPX2 +6 more

Primary bile acid biosynthesis Synthesis of bile acids and bile salts via 24-hydroxycholesterol Endogenous sterols

Neddylation

Neurexins and neuroligins

Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification LTC4-CYSLTR mediated IL4 production

mTOR signaling pathway Wnt signaling pathway Notch signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells Melanogenesis Cushing syndrome Alzheimer disease Pathways of neurodegeneration - multiple diseases Human papillomavirus infection Pathways in cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer WNT mediated activation of DVL PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping +18 more

Mitophagy - animal Autophagy - animal Protein processing in endoplasmic reticulum Apoptosis Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Hepatitis C Measles Herpes simplex virus 1 infection Lipid and atherosclerosis PERK regulates gene expression +12 more

Measles L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit +4 more

Trafficking of AMPA receptors Neurexins and neuroligins

Axon guidance EPH-Ephrin signaling EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells +2 more

ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis