Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
Brain Stem Glioblastoma	EFO_1000141	GAS7	Unknown	24705251	Open Targets	—
		GNA11	Unknown	24705251	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Hormone signaling +23 more
		GNAQ	Unknown	24705251	Open Targets	Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +52 more
		GNAS	Unknown	24705251	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		GPC3	Unknown	24705251	Open Targets	Proteoglycans in cancer A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis +9 more
		GPC5	Unknown	24705251	Open Targets	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation +7 more
		GPHN	Unknown	24705251	Open Targets	Folate biosynthesis Metabolic pathways Biosynthesis of cofactors +2 more
		GRIN2A	Unknown	24705251	Open Targets	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		GRM3	Unknown	24705251	Open Targets	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more
		H3-3A	Unknown	24705252 24242757 28447171 26376656 23079654 22661320 24705251 24880341	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +18 more
		H3C2	Unknown	24705252 24242757 24705251	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +27 more
		HERPUD1	Unknown	24705252	Open Targets	Protein processing in endoplasmic reticulum ATF4 activates genes in response to endoplasmic reticulum stress
		HLF	Unknown	24705251	Open Targets	—
		HMGA2	Unknown	24705251	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Formation of Senescence-Associated Heterochromatin Foci (SAHF)
		HNRNPA2B1	Unknown	24705251	Open Targets	Amyotrophic lateral sclerosis mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA +1 more
		HOOK3	Unknown	24705251	Open Targets	Motor proteins
		HOXA13	Unknown	24705251	Open Targets	—
		IDH1	Unknown	24880341 35079479 24242757	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IKBKB	Unknown	24705251	Open Targets	Antifolate resistance MAPK signaling pathway Ras signaling pathway +79 more
		IKZF3	Unknown	24705251	Open Targets	—
		ITGAV	Unknown	24705251	Open Targets	Hormone signaling Phagosome Efferocytosis +26 more
		ITK	Unknown	24705251	Open Targets	Chemokine signaling pathway T cell receptor signaling pathway Leukocyte transendothelial migration +2 more
		JAK2	Unknown	24705251	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAZF1	Unknown	24705251	Open Targets	—
		KDM5C	Unknown	24705251	Open Targets	HDMs demethylate histones
		KDM6A	Unknown	24705251	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KDR	Unknown	24705251	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		KEAP1	Unknown	24705251	Open Targets	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		KIAA1549	Unknown	24705252	Open Targets	Signaling by BRAF and RAF fusions
		KIT	Unknown	24705251	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2C	Unknown	24705251	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KNL1	Unknown	24705251	Open Targets	Cell cycle Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		KTN1	Unknown	24705251	Open Targets	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
		LARP4B	Unknown	24705251	Open Targets	—
		LATS2	Unknown	24705251	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LCP1	Unknown	24705251	Open Targets	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
		LEF1	Unknown	24705251	Open Targets	Wnt signaling pathway Hippo signaling pathway Adherens junction +24 more
		LHFPL6	Unknown	24705251	Open Targets	—
		LIFR	Unknown	24705251	Open Targets	Cytokine-cytokine receptor interaction Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway +2 more
		LOC100506403	Unknown	24705251	Open Targets	—
		LPP	Unknown	24705251	Open Targets	—
		LRP1B	Unknown	24705252 24705251	Open Targets	—
		LSM14A	Unknown	24705251	Open Targets	—
		LYN	Unknown	24705251	Open Targets	Chemokine signaling pathway NF-kappa B signaling pathway Platelet activation +36 more
		MALT1	Unknown	24705251	Open Targets	NF-kappa B signaling pathway C-type lectin receptor signaling pathway T cell receptor signaling pathway +8 more
		MAML2	Unknown	24705251	Open Targets	Notch signaling pathway Th1 and Th2 cell differentiation Human papillomavirus infection +9 more
		MAP3K13	Unknown	24705251	Open Targets	MAPK signaling pathway
		MAX	Unknown	24705251	Open Targets	Polycomb repressive complex MAPK signaling pathway Pathways in cancer +6 more
		MECOM	Unknown	24705251	Open Targets	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
		MET	Unknown	24705251	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more

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Brain stem glioblastoma

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