Subtype of: Astrocytoma · Glioblastoma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
astrocytoma (excluding glioblastoma)	MONDO_0019781	SGK1	Unknown	25642631	Open Targets	FoxO signaling pathway Efferocytosis mTOR signaling pathway +6 more
		SH2B3	Unknown	25642631 29973652	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SH3GL1	Unknown	25642631	Open Targets	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
		SHTN1	Unknown	25642631	Open Targets	—
		SIX1	Unknown	25642631	Open Targets	Transcriptional misregulation in cancer
		SIX2	Unknown	23104868	Open Targets	—
		SMAD3	Unknown	25642631	Open Targets	FoxO signaling pathway Cell cycle Endocytosis +34 more
		SMARCA4	Unknown	25642631	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SMARCB1	Unknown	25642631	Open Targets	ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis +3 more
		SMC1A	Unknown	25642631	Open Targets	Cell cycle Oocyte meiosis Separation of Sister Chromatids +5 more
		SMO	Unknown	25642631 26487540	Open Targets	Hedgehog signaling pathway Axon guidance Pathways in cancer +6 more
		SND1	Unknown	25642631	Open Targets	Viral carcinogenesis Signaling by BRAF and RAF fusions
		SOS1	Unknown	25642631	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +97 more
		SOX21	Unknown	25642631	Open Targets	—
		SPEN	Unknown	24705252 25642631 29973652	Open Targets	Notch signaling pathway
		SRGAP3	Unknown	25642631 19373855	Open Targets	Axon guidance Rho GTPase cycle
		SRSF3	Unknown	25642631	Open Targets	Spliceosome Amyotrophic lateral sclerosis Herpes simplex virus 1 infection +4 more
		SS18L1	Unknown	25642631	Open Targets	ATP-dependent chromatin remodeling Transcriptional misregulation in cancer
		SSX1	Unknown	29973652	Open Targets	Transcriptional misregulation in cancer
		STAG1	Unknown	37792958	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		STAG2	Unknown	29973652	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		STAT3	Unknown	29973652	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway HIF-1 signaling pathway +53 more
		STK11	Unknown	29973652	Open Targets	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		STRN	Unknown	25642631	Open Targets	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +2 more
		SUZ12	Unknown	25642631	Open Targets	Polycomb repressive complex PRC2 methylates histones and DNA Oxidative Stress Induced Senescence +5 more
		SYK	Unknown	25642631	Open Targets	NF-kappa B signaling pathway Phospholipase D signaling pathway PI3K-Akt signaling pathway +30 more
		TBX3	Unknown	24705252	Open Targets	Signaling pathways regulating pluripotency of stem cells
		TCF12	Unknown	37792958	Open Targets	Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription
		TCL1A	Unknown	24140581	Open Targets	PI3K-Akt signaling pathway
		TERT	Unknown	25642631	Open Targets	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
		TET1	Unknown	25642631	Open Targets	—
		TET2	Unknown	29263181	Open Targets	—
		TFRC	Unknown	25642631	Open Targets	Virion - Lassa virus and SFTS virus HIF-1 signaling pathway Endocytosis +8 more
		TGFBR2	Unknown	25642631	Open Targets	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +28 more
		TNC	Unknown	37792958 25642631	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +6 more
		TNFRSF14	Unknown	25642631 26487540	Open Targets	Virion - Herpesvirus Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +3 more
		TNRC18	Unknown	25642631	Open Targets	—
		TOP1	Unknown	25642631 29973652	Open Targets	SUMOylation of DNA replication proteins
		TP53	Unknown	37792958 25667294 32068851 31350684 25257301 11152345 32069381 34301788 11724349 24880341 23104868 25085214 22844452 25036404 24714777 9650746 24705252 22821383 24868540 24767714 29026176 37401089 20068183 25642631 37554222 29683790 24140581 23547069 38581197 29263181 37077830	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TP63	Unknown	25642631 28481359	Open Targets	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TPR	Unknown	25642631	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Pathways in cancer +27 more
		TRIM33	Unknown	25642631	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity
		TRIP11	Unknown	29973652	Open Targets	Intraflagellar transport Intra-Golgi traffic
		TRRAP	Unknown	25642631	Open Targets	ATP-dependent chromatin remodeling Human T-cell leukemia virus 1 infection Formation of the beta-catenin:TCF transactivating complex +1 more
		TSC1	Unknown	25642631	Open Targets	Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway +15 more
		TSC2	Unknown	25642631 29973652	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		U2AF1	Unknown	25642631	Open Targets	Spliceosome Shigellosis Transport of Mature mRNA derived from an Intron-Containing Transcript +3 more
		UBR5	Unknown	25642631	Open Targets	Ubiquitin mediated proteolysis
		USP44	Unknown	25642631	Open Targets	Ub-specific processing proteases
		USP6	Unknown	24705252	Open Targets	—

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Astrocytoma (excluding glioblastoma)

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