Subtype of: Astrocytoma · Glioblastoma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
astrocytoma (excluding glioblastoma)	MONDO_0019781	PPP2R1A	Unknown	29973652	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PRCC	Unknown	25642631	Open Targets	Transcriptional misregulation in cancer Renal cell carcinoma mRNA Splicing - Major Pathway
		PRDM1	Unknown	25642631	Open Targets	Regulation of TP53 Expression
		PRDM2	Unknown	25642631	Open Targets	Lysine degradation Metabolic pathways
		PREX2	Unknown	24705252	Open Targets	Regulation of PTEN stability and activity
		PRKAR1A	Unknown	25642631	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		PRKCB	Unknown	25642631	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +77 more
		PRKD1	Unknown	25642631	Open Targets	Rap1 signaling pathway Aldosterone synthesis and secretion Chemical carcinogenesis - reactive oxygen species +1 more
		PTCH1	Unknown	25642631 26487540	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	15679305 25257301 17098662 15779579 9681833 29263181 19350382	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPN11	Unknown	24705252 38447592	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		PTPN13	Unknown	29263181 26487540	Open Targets	Apoptosis Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
		PTPRB	Unknown	25642631	Open Targets	Adherens junction Neutrophil degranulation
		PTPRD	Unknown	25642631	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		PTPRT	Unknown	24705252 25642631	Open Targets	—
		PWWP2A	Unknown	25642631	Open Targets	—
		QKI	Unknown	25642631	Open Targets	Signaling by BRAF and RAF fusions
		RABEP1	Unknown	25642631 23592488	Open Targets	Endocytosis TBC/RABGAPs
		RAD21	Unknown	25642631	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		RAD50	Unknown	25642631	Open Targets	Homologous recombination Non-homologous end-joining Cellular senescence +14 more
		RAD51	Unknown	25642631	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +8 more
		RAF1	Unknown	19373855	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +93 more
		RALGDS	Unknown	23104868	Open Targets	Ras signaling pathway Rap1 signaling pathway Phospholipase D signaling pathway +5 more
		RANBP2	Unknown	29263181	Open Targets	Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis +32 more
		RAP1B	Unknown	25642631	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +25 more
		RASA1	Unknown	25642631	Open Targets	MAPK signaling pathway Ras signaling pathway Axon guidance +5 more
		RBM10	Unknown	25642631	Open Targets	—
		RBM15	Unknown	25642631	Open Targets	—
		RECQL4	Unknown	25642631	Open Targets	—
		RFWD3	Unknown	25642631	Open Targets	—
		RGPD3	Unknown	29263181	Open Targets	—
		RNF213	Unknown	25642631	Open Targets	Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation
		RNF43	Unknown	29973652	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
		ROBO2	Unknown	25642631 24140581	Open Targets	Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
		ROCK1	Unknown	25642631	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway +25 more
		RPL10	Unknown	25642631	Open Targets	Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression +7 more
		RPN1	Unknown	25642631	Open Targets	N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways +2 more
		RSPO2	Unknown	25642631	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination
		RUNX1T1	Unknown	25642631	Open Targets	Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia
		RXRA	Unknown	25642631	Open Targets	PPAR signaling pathway Efferocytosis PI3K-Akt signaling pathway +39 more
		SALL4	Unknown	25642631	Open Targets	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Regulation of PTEN gene transcription
		SDHA	Unknown	26487540	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SDHB	Unknown	37792958	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SEPTIN6	Unknown	25642631	Open Targets	Bacterial invasion of epithelial cells Shigellosis
		SEPTIN9	Unknown	25642631	Open Targets	Bacterial invasion of epithelial cells Shigellosis
		SETBP1	Unknown	25642631	Open Targets	—
		SETD1B	Unknown	37792958 25642631 29263181	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		SETD2	Unknown	37401089 25642631	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SETDB1	Unknown	25642631	Open Targets	Lysine degradation Metabolic pathways Signaling pathways regulating pluripotency of stem cells +1 more
		SFPQ	Unknown	25642631	Open Targets	PTK6 Regulates Proteins Involved in RNA Processing Suppression of apoptosis

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Astrocytoma (excluding glioblastoma)

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