Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
angiosarcoma	MONDO_0016982	PDGFRA	Unknown	24633157	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		PER1	Unknown	37106027	Open Targets	Circadian rhythm Circadian entrainment
		PHF6	Unknown	37106027	Open Targets	ATP-dependent chromatin remodeling
		PHOX2B	Unknown	24633157	Open Targets	—
		PICALM	Unknown	24633157	Open Targets	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
		PIERCE2	Unknown	24633157	Open Targets	—
		PIK3CA	Unknown	37106027 24633157 35154272 22779686 28481359 31510873	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3CB	Unknown	28481359 36788076 24633157	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +126 more
		PIK3R1	Unknown	24633157	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PLCG1	Unknown	26440310 25252913 37106027 24633157 26735859 31510873 26474454	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +70 more
		PMS1	Unknown	37106027	Open Targets	—
		PMS2	Unknown	37106027	Open Targets	Mismatch repair Fanconi anemia pathway Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) +3 more
		POLD1	Unknown	37106027 24633157	Open Targets	DNA replication Base excision repair Nucleotide excision repair +19 more
		POLE	Unknown	37106027	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		POLQ	Unknown	37106027 36788076 24633157	Open Targets	HDR through MMEJ (alt-NHEJ)
		POT1	Unknown	37106027 25252913 31510873	Open Targets	Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends +2 more
		POU5F1	Unknown	37106027	Open Targets	Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation +1 more
		PPARG	Unknown	37106027	Open Targets	PPAR signaling pathway Efferocytosis AMPK signaling pathway +13 more
		PPM1D	Unknown	37106027	Open Targets	p53 signaling pathway Transcriptional regulation by RUNX2
		PPP2R1A	Unknown	37106027	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PPP6C	Unknown	37106027	Open Targets	COPII-mediated vesicle transport
		PRCC	Unknown	37106027	Open Targets	Transcriptional misregulation in cancer Renal cell carcinoma mRNA Splicing - Major Pathway
		PRDM1	Unknown	33016928 28481359	Open Targets	Regulation of TP53 Expression
		PRDM16	Unknown	37106027 24633157	Open Targets	Lysine degradation Metabolic pathways Thermogenesis +1 more
		PREX2	Unknown	24633157	Open Targets	Regulation of PTEN stability and activity
		PRKACA	Unknown	37106027	Open Targets	Endocrine resistance MAPK signaling pathway Ras signaling pathway +95 more
		PRKCB	Unknown	36788076	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +77 more
		PRKD1	Unknown	24633157	Open Targets	Rap1 signaling pathway Aldosterone synthesis and secretion Chemical carcinogenesis - reactive oxygen species +1 more
		PTCH1	Unknown	37106027 28481359	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	28481359 36788076	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTK6	Unknown	24633157	Open Targets	SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 ERBB2 Activates PTK6 Signaling +8 more
		PTPN13	Unknown	37106027 24633157	Open Targets	Apoptosis Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
		PTPN6	Unknown	24633157	Open Targets	Efferocytosis Adherens junction JAK-STAT signaling pathway +22 more
		PTPRB	Unknown	37106027 26440310 24633157	Open Targets	Adherens junction Neutrophil degranulation
		PTPRC	Unknown	37106027	Open Targets	Cell adhesion molecules T cell receptor signaling pathway Fc gamma R-mediated phagocytosis +5 more
		PTPRD	Unknown	28481359 37106027 36788076 24633157	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		PTPRK	Unknown	37106027 24633157	Open Targets	EGFR downregulation
		PTPRT	Unknown	36788076 24633157	Open Targets	—
		RABEP1	Unknown	37106027	Open Targets	Endocytosis TBC/RABGAPs
		RAD50	Unknown	28481359 37106027 36788076 24633157	Open Targets	Homologous recombination Non-homologous end-joining Cellular senescence +14 more
		RAD51B	Unknown	37106027 31510873 24633157	Open Targets	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +4 more
		RAD51C	Unknown	31510873 24633157	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +5 more
		RAF1	Unknown	25252913 37106027 36788076 24633157	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +93 more
		RALGDS	Unknown	37106027	Open Targets	Ras signaling pathway Rap1 signaling pathway Phospholipase D signaling pathway +5 more
		RANBP2	Unknown	24633157	Open Targets	Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis +32 more
		RAP1GDS1	Unknown	36788076 24633157	Open Targets	—
		RASA1	Unknown	37106027 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Axon guidance +5 more
		RECQL4	Unknown	37106027	Open Targets	—
		REL	Unknown	37106027	Open Targets	Ras signaling pathway Transcriptional misregulation in cancer Viral carcinogenesis +1 more
		RET	Unknown	37106027	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more

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Angiosarcoma

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