Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
angiosarcoma	MONDO_0016982	KDSR	Unknown	24633157	Open Targets	Sphingolipid metabolism Metabolic pathways Sphingolipid de novo biosynthesis
		KIAA1549	Unknown	36788076	Open Targets	Signaling by BRAF and RAF fusions
		KIF5B	Unknown	37106027	Open Targets	Endocytosis Dopaminergic synapse Motor proteins +12 more
		KLF4	Unknown	28481359	Open Targets	Signaling pathways regulating pluripotency of stem cells Chemical carcinogenesis - receptor activation Synthesis, secretion, and deacylation of Ghrelin +1 more
		KLK2	Unknown	37106027	Open Targets	Renin-angiotensin system Endocrine and other factor-regulated calcium reabsorption Activation of Matrix Metalloproteinases +2 more
		KMT2A	Unknown	37106027 24633157	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	37106027 36788076 31510873 24633157	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	33016928 25252913 37106027 28481359 31510873	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	8061177 9010458 37106027 12211074 10735503 1793483 24633157	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		KTN1	Unknown	37106027	Open Targets	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
		LARP4B	Unknown	37106027 24633157	Open Targets	—
		LATS1	Unknown	37106027	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LATS2	Unknown	24633157	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LCP1	Unknown	37106027 24633157	Open Targets	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
		LEF1	Unknown	24633157	Open Targets	Wnt signaling pathway Hippo signaling pathway Adherens junction +24 more
		LIFR	Unknown	37106027	Open Targets	Cytokine-cytokine receptor interaction Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway +2 more
		LOC100506403	Unknown	24633157	Open Targets	—
		LOC105376156	Unknown	28481359 36788076 24633157	Open Targets	—
		LPP	Unknown	24633157	Open Targets	—
		LRIG3	Unknown	37106027	Open Targets	—
		LRP1B	Unknown	37106027 36788076 31510873 24633157	Open Targets	—
		LZTR1	Unknown	37106027 24633157	Open Targets	—
		MACC1	Unknown	24633157	Open Targets	—
		MAML2	Unknown	37106027 31510873 24633157	Open Targets	Notch signaling pathway Th1 and Th2 cell differentiation Human papillomavirus infection +9 more
		MAP2K1	Unknown	31510873	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +99 more
		MAP2K2	Unknown	37106027	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +87 more
		MAP2K4	Unknown	33016928	Open Targets	MAPK signaling pathway ErbB signaling pathway Toll-like receptor signaling pathway +21 more
		MAP3K1	Unknown	28481359 33016928 37106027 36788076	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAP3K13	Unknown	37106027	Open Targets	MAPK signaling pathway
		MAPK1	Unknown	37106027 26440310	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +161 more
		MAX	Unknown	37106027	Open Targets	Polycomb repressive complex MAPK signaling pathway Pathways in cancer +6 more
		MB21D2	Unknown	24633157	Open Targets	—
		MDM2	Unknown	37106027 28481359 24633157	Open Targets	Endocrine resistance Platinum drug resistance FoxO signaling pathway +35 more
		MDM4	Unknown	37106027	Open Targets	p53 signaling pathway MicroRNAs in cancer Oxidative Stress Induced Senescence +6 more
		MECOM	Unknown	37106027 36788076 24633157	Open Targets	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
		MED12	Unknown	26822237 24633157 31510873	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MET	Unknown	37106027 28481359 24633157	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MGMT	Unknown	36788076 24633157	Open Targets	MGMT-mediated DNA damage reversal
		MITF	Unknown	37106027 24633157	Open Targets	Mitophagy - animal Osteoclast differentiation Melanogenesis +4 more
		MLF1	Unknown	37106027	Open Targets	Transcriptional misregulation in cancer
		MLH1	Unknown	37106027 28481359	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MLLT10	Unknown	37106027	Open Targets	—
		MLLT3	Unknown	37106027 24633157	Open Targets	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more
		MPL	Unknown	33016928	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		MSH2	Unknown	37106027 28481359 24633157	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MSH6	Unknown	37106027 31510873	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MSI2	Unknown	24633157	Open Targets	mRNA surveillance pathway
		MSN	Unknown	33016928	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +4 more
		MTOR	Unknown	26859683 37106027 24633157	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MUC16	Unknown	37106027 36788076	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more

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Angiosarcoma

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