Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
angiosarcoma	MONDO_0016982	FHIT	Unknown	24633157	Open Targets	Purine metabolism Metabolic pathways Small cell lung cancer +1 more
		FIP1L1	Unknown	37106027 24633157	Open Targets	mRNA surveillance pathway Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway +4 more
		FLCN	Unknown	24633157	Open Targets	mTOR signaling pathway Renal cell carcinoma Amino acids regulate mTORC1
		FLI1	Unknown	24633157	Open Targets	Transcriptional misregulation in cancer
		FLT3	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		FLT4	Unknown	37106027 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		FNBP1	Unknown	37106027	Open Targets	Shigellosis Clathrin-mediated endocytosis
		FOXO1	Unknown	37106027 28481359	Open Targets	FoxO signaling pathway AMPK signaling pathway Longevity regulating pathway +23 more
		FOXO3	Unknown	24633157	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway FoxO signaling pathway +26 more
		FOXP1	Unknown	37106027	Open Targets	MicroRNAs in cancer Transcriptional regulation of pluripotent stem cells
		FUBP1	Unknown	37106027	Open Targets	—
		GAS7	Unknown	24633157	Open Targets	—
		GLI1	Unknown	37106027	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Pathways in cancer +5 more
		GNA11	Unknown	24633157	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Hormone signaling +23 more
		GOLGA5	Unknown	37106027	Open Targets	Intra-Golgi traffic
		GOPC	Unknown	37106027	Open Targets	RHO GTPases regulate CFTR trafficking
		GPC3	Unknown	36788076	Open Targets	Proteoglycans in cancer A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis +9 more
		GPC5	Unknown	36788076 24633157	Open Targets	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation +7 more
		GPHN	Unknown	24633157	Open Targets	Folate biosynthesis Metabolic pathways Biosynthesis of cofactors +2 more
		GRIN2A	Unknown	37106027 36788076 24633157	Open Targets	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		GRM3	Unknown	24633157	Open Targets	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more
		GSK3B	Unknown	37106027 36788076 24633157	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Chemokine signaling pathway +59 more
		GTF2I	Unknown	24633157	Open Targets	Basal transcription factors cGMP-PKG signaling pathway
		HGF	Unknown	28481359 24633157	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +29 more
		HIF1A	Unknown	37106027 36788076	Open Targets	HIF-1 signaling pathway Mitophagy - animal Autophagy - animal +19 more
		HLA-A	Unknown	31510873	Open Targets	Endocytosis Phagosome Cellular senescence +25 more
		HMGA2	Unknown	36788076	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Formation of Senescence-Associated Heterochromatin Foci (SAHF)
		HOOK3	Unknown	37106027 36788076	Open Targets	Motor proteins
		HOXA9	Unknown	24633157	Open Targets	Transcriptional misregulation in cancer
		HOXD11	Unknown	31510873	Open Targets	—
		HRAS	Unknown	28481359 26440310 24633157	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		HSP90AB1	Unknown	37106027	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +26 more
		IKBKB	Unknown	24633157	Open Targets	Antifolate resistance MAPK signaling pathway Ras signaling pathway +79 more
		IKZF1	Unknown	37106027	Open Targets	—
		IL21R	Unknown	36788076	Open Targets	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +2 more
		IL6ST	Unknown	37106027 24633157	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Signaling pathways regulating pluripotency of stem cells +12 more
		IRF4	Unknown	28481359	Open Targets	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		ITGAV	Unknown	33016928 31510873 24633157	Open Targets	Hormone signaling Phagosome Efferocytosis +26 more
		ITK	Unknown	24633157	Open Targets	Chemokine signaling pathway T cell receptor signaling pathway Leukocyte transendothelial migration +2 more
		JAK1	Unknown	37106027	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAK2	Unknown	37106027	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAK3	Unknown	28481359	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		JAZF1	Unknown	24633157	Open Targets	—
		KAT6A	Unknown	37106027 24633157	Open Targets	Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation
		KAT6B	Unknown	37106027	Open Targets	HATs acetylate histones
		KCNJ5	Unknown	37106027	Open Targets	Circadian entrainment Retrograde endocannabinoid signaling Serotonergic synapse +8 more
		KDM5A	Unknown	37106027	Open Targets	HDMs demethylate histones
		KDM5C	Unknown	28481359	Open Targets	HDMs demethylate histones
		KDM6A	Unknown	24633157	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KDR	Unknown	25252913 37106027 33016928 28481359 19723655 31510873	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more

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Angiosarcoma

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