Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
angiosarcoma	MONDO_0016982	TET2	Unknown	37106027	Open Targets	—
		TFPT	Unknown	37106027 36788076	Open Targets	ATP-dependent chromatin remodeling UCH proteinases DNA Damage Recognition in GG-NER
		TGFBR2	Unknown	28481359 24633157	Open Targets	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +28 more
		TNFAIP3	Unknown	37106027	Open Targets	NF-kappa B signaling pathway Necroptosis NOD-like receptor signaling pathway +10 more
		TNRC18	Unknown	31510873	Open Targets	—
		TOP1	Unknown	37106027	Open Targets	SUMOylation of DNA replication proteins
		TP53	Unknown	7586214 9811333 9185695 24633157 37106027 8293534 33016928 28481359 31510873 26474454	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TP63	Unknown	28481359	Open Targets	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TPM3	Unknown	37106027 24633157	Open Targets	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +7 more
		TPR	Unknown	37106027	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Pathways in cancer +27 more
		TRAF7	Unknown	37106027 24633157	Open Targets	Antigen processing: Ubiquitination & Proteasome degradation
		TRIM27	Unknown	37106027	Open Targets	SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis
		TRIP11	Unknown	37106027	Open Targets	Intraflagellar transport Intra-Golgi traffic
		TRRAP	Unknown	37106027 24633157	Open Targets	ATP-dependent chromatin remodeling Human T-cell leukemia virus 1 infection Formation of the beta-catenin:TCF transactivating complex +1 more
		TSC1	Unknown	28481359	Open Targets	Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway +15 more
		TSC2	Unknown	37106027 28481359	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		TSHR	Unknown	36788076 24633157	Open Targets	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more
		U2AF1	Unknown	37106027	Open Targets	Spliceosome Shigellosis Transport of Mature mRNA derived from an Intron-Containing Transcript +3 more
		UBR5	Unknown	37106027	Open Targets	Ubiquitin mediated proteolysis
		USP44	Unknown	24633157	Open Targets	Ub-specific processing proteases
		USP6	Unknown	24633157	Open Targets	—
		USP8	Unknown	37106027	Open Targets	Mitophagy - animal Endocytosis Cushing syndrome +4 more
		USP9X	Unknown	37106027	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes +2 more
		VTI1A	Unknown	24633157	Open Targets	SNARE interactions in vesicular transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
		WRN	Unknown	37106027 36788076	Open Targets	Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins +9 more
		WT1	Unknown	37106027 28481359	Open Targets	Transcriptional misregulation in cancer
		XPC	Unknown	37106027	Open Targets	Nucleotide excision repair SUMOylation of DNA damage response and repair proteins DNA Damage Recognition in GG-NER +1 more
		YAP1	Unknown	24633157	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Nuclear signaling by ERBB4 +5 more
		YWHAE	Unknown	22223660	Open Targets	Cell cycle Oocyte meiosis PI3K-Akt signaling pathway +22 more
		ZEB1	Unknown	36788076	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Prostate cancer +1 more
		ZFHX3	Unknown	37106027 28481359 24633157	Open Targets	Signaling pathways regulating pluripotency of stem cells RUNX3 regulates CDKN1A transcription
		ZMYM2	Unknown	37106027	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease
		ZNF331	Unknown	37106027 26474454	Open Targets	Generic Transcription Pathway
		ZNF429	Unknown	36788076	Open Targets	Generic Transcription Pathway
		ZNF521	Unknown	36788076 24633157	Open Targets	—
		ZNRF3	Unknown	24633157	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination

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Angiosarcoma

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