Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
anaplastic large cell lymphoma	MONDO_0020325	ALK	Unknown	11943732 15297972 17464320 18776764 9250148 10216106 20658615 8562933 10555007 8616079 9844824 9517514 19545284 11310834 9450809 8683377 10192426 7780128 7856744 8122112 8701987 10807789 9777981 7662979 12707379 10706887 8558920 10556217 23239810 11215285 12401829 16651537 10702393 7772531 7579458 19135051 9449486 8781434 8781433 18572809 11493472 12112524 10610119 15214912 10706082 10552961 9598798 11178628	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		ARID1B	Unknown	27203213 34382383	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ASXL1	Unknown	34382383	Open Targets	Polycomb repressive complex UCH proteinases
		ATIC	Unknown	17464320 18572809 11493472 19545284 10706082 11310834 10706887 10702393	Open Targets	Purine metabolism One carbon pool by folate Metabolic pathways +2 more
		ATM	Unknown	27203213	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		AXIN1	Unknown	34382383	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		BCOR	Unknown	34382383	Open Targets	Polycomb repressive complex
		BIRC6	Unknown	34382383	Open Targets	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species
		CAMTA1	Unknown	34382383	Open Targets	—
		CBLC	Unknown	27203213	Open Targets	Ubiquitin mediated proteolysis Endocytosis
		CCND1	Unknown	28481359	Open Targets	Endocrine resistance FoxO signaling pathway Cell cycle +58 more
		CDKN2A	Unknown	20118908	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CHEK2	Unknown	27203213	Open Targets	Cell cycle p53 signaling pathway Cellular senescence +9 more
		CLTC	Unknown	19545284 11310834 10807789 12112524 19135051	Open Targets	Lysosome Endocytosis Synaptic vesicle cycle +18 more
		COL3A1	Unknown	34382383	Open Targets	Platelet activation Cytoskeleton in muscle cells Relaxin signaling pathway +16 more
		CREB3L1	Unknown	34382383	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway +32 more
		CREBBP	Unknown	34382383	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		CSMD3	Unknown	34382383	Open Targets	—
		DNMT3A	Unknown	29386642 26268241	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		EP300	Unknown	27203213	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +66 more
		ERBB4	Unknown	34382383	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		FANCD2	Unknown	27203213	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
		FIP1L1	Unknown	27203213	Open Targets	mRNA surveillance pathway Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway +4 more
		FLNA	Unknown	34382383	Open Targets	MAPK signaling pathway Focal adhesion Salmonella infection +6 more
		FLT3	Unknown	34382383	Open Targets	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		FSTL3	Unknown	34382383	Open Targets	Antagonism of Activin by Follistatin Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
		GATA2	Unknown	34382383	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		IRF4	Unknown	27203213	Open Targets	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		JAK1	Unknown	28356514	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		KDM5A	Unknown	34382383	Open Targets	HDMs demethylate histones
		KMT2C	Unknown	27203213	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		LOC100506403	Unknown	29386642	Open Targets	—
		LOC124905021	Unknown	27203213	Open Targets	—
		LRP1B	Unknown	34382383	Open Targets	—
		MAP3K1	Unknown	34382383	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MLLT10	Unknown	34382383	Open Targets	—
		MSN	Unknown	11310834 15297972	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +4 more
		MUC4	Unknown	34382383	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		NBEA	Unknown	34382383	Open Targets	—
		NOTCH1	Unknown	27203213 22116551	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	27203213	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NPM1	Unknown	17464320 18776764 9250148 10216106 20658615 8562933 10555007 8616079 9844824 9517514 19545284 11310834 9450809 8683377 10192426 7780128 7856744 8122112 8701987 9777981 7662979 8558920 11215285 12401829 16651537 10702393 7772531 7579458 19135051 9449486 8781434 8781433 11493472 15214912 10552961 9598798 11178628	Open Targets	Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere +2 more
		NRAS	Unknown	21209378	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NTRK2	Unknown	34382383	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more
		NUP214	Unknown	27203213	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism +26 more
		NUP98	Unknown	34382383	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A +33 more
		PAX8	Unknown	34382383	Open Targets	Thyroid hormone synthesis Pathways in cancer Transcriptional misregulation in cancer +1 more
		PBRM1	Unknown	27203213	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		PDE4DIP	Unknown	34382383	Open Targets	—
		PIK3R1	Unknown	27203213 34382383	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more

Anaplastic large cell lymphoma

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