Anaplastic (malignant) meningioma

Endocrine resistance ErbB signaling pathway HIF-1 signaling pathway FoxO signaling pathway Cell cycle PI3K-Akt signaling pathway AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Measles Human papillomavirus infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis MicroRNAs in cancer Prostate cancer Chronic myeloid leukemia Small cell lung cancer Gastric cancer SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Constitutive Signaling by AKT1 E17K in Cancer TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates Cell Cycle Estrogen-dependent nuclear events downstream of ESR-membrane signaling +28 more

Endocrine resistance Platinum drug resistance Cell cycle p53 signaling pathway Cellular senescence Cushing syndrome Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Pathways in cancer Viral carcinogenesis MicroRNAs in cancer Pancreatic cancer Glioma Melanoma Bladder cancer Chronic myeloid leukemia Non-small cell lung cancer Hepatocellular carcinoma Apoptotic factor-mediated response Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors Regulation of TP53 Degradation Cyclin D associated events in G1 Stabilization of p53 Transcriptional Regulation by VENTX Regulation of RUNX3 expression and activity Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function Evasion of Oncogene Induced Senescence Due to p14ARF Defects Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects +33 more

Anchoring of the basal body to the plasma membrane

ATP-dependent chromatin remodeling Human papillomavirus infection Viral carcinogenesis HDACs deacetylate histones Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription NGF-stimulated transcription +5 more

mTOR signaling pathway Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases activate IQGAPs RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation +5 more

Lysosome Endocytosis Synaptic vesicle cycle Endocrine and other factor-regulated calcium reabsorption Huntington disease Bacterial invasion of epithelial cells Entry of Influenza Virion into Host Cell via Endocytosis Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance +18 more

Cell adhesion molecules

Oocyte meiosis Progesterone-mediated oocyte maturation

cGMP-PKG signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Adrenergic signaling in cardiomyocytes TNF signaling pathway Thermogenesis Cholinergic synapse Dopaminergic synapse Insulin secretion Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Glucagon signaling pathway Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action Insulin resistance Cushing syndrome Growth hormone synthesis, secretion and action Vasopressin-regulated water reabsorption Huntington disease Prion disease Cocaine addiction Amphetamine addiction Alcoholism Hepatitis B Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Viral carcinogenesis Chemical carcinogenesis - receptor activation Prostate cancer +32 more

Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway HIF-1 signaling pathway FoxO signaling pathway Cell cycle Wnt signaling pathway Notch signaling pathway TGF-beta signaling pathway Adherens junction JAK-STAT signaling pathway Long-term potentiation Melanogenesis Thyroid hormone signaling pathway Glucagon signaling pathway Growth hormone synthesis, secretion and action Huntington disease Tuberculosis Hepatitis B Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Viral carcinogenesis MicroRNAs in cancer Renal cell carcinoma Prostate cancer Regulation of gene expression by Hypoxia-inducible Factor RORA activates gene expression Pre-NOTCH Transcription and Translation PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Attenuation phase Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock CD209 (DC-SIGN) signaling TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Regulation of FOXO transcriptional activity by acetylation +52 more

Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Interleukin-7 signaling

Human T-cell leukemia virus 1 infection Transcriptional activation of mitochondrial biogenesis Circadian Clock

Hippo signaling pathway Adherens junction Leukocyte transendothelial migration Bacterial invasion of epithelial cells Pathways in cancer Endometrial cancer Gastric cancer Arrhythmogenic right ventricular cardiomyopathy Adherens junctions interactions VEGFR2 mediated vascular permeability Myogenesis RHO GTPases activate IQGAPs +9 more

Hippo signaling pathway Adherens junction Leukocyte transendothelial migration Bacterial invasion of epithelial cells Pathways in cancer Endometrial cancer Gastric cancer Arrhythmogenic right ventricular cardiomyopathy Myogenesis +6 more

Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway Focal adhesion Adherens junction Signaling pathways regulating pluripotency of stem cells Leukocyte transendothelial migration Melanogenesis Thyroid hormone signaling pathway Cushing syndrome Alcoholic liver disease Alzheimer disease Pathways of neurodegeneration - multiple diseases Bacterial invasion of epithelial cells Salmonella infection Hepatitis C Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Proteoglycans in cancer Colorectal cancer Endometrial cancer Prostate cancer Thyroid cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer Arrhythmogenic right ventricular cardiomyopathy Fluid shear stress and atherosclerosis Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Apoptotic cleavage of cell adhesion proteins Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Adherens junctions interactions Binding of TCF/LEF:CTNNB1 to target gene promoters Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Myogenesis Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated RHO GTPases activate IQGAPs Transcriptional Regulation by VENTX InlA-mediated entry of Listeria monocytogenes into host cells RUNX3 regulates WNT signaling +51 more

Wnt signaling pathway

Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic

MAPK signaling pathway Apoptosis Parkinson disease Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Herpes simplex virus 1 infection SUMOylation of transcription cofactors Regulation of TP53 Degradation HCMV Early Events +6 more

Axon guidance Pathways in cancer Colorectal cancer Netrin-1 signaling DCC mediated attractive signaling Caspase activation via Dependence Receptors in the absence of ligand +3 more

Non-integrin membrane-ECM interactions

RIG-I-like receptor signaling pathway Hepatitis B Viral carcinogenesis Neutrophil degranulation +1 more

Phospholipase D signaling pathway Endocytosis Fc gamma R-mediated phagocytosis Synaptic vesicle cycle Endocrine and other factor-regulated calcium reabsorption Bacterial invasion of epithelial cells Salmonella infection Toll Like Receptor 4 (TLR4) Cascade Gap junction degradation Formation of annular gap junctions NOSTRIN mediated eNOS trafficking MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Clathrin-mediated endocytosis +13 more

Cysteine and methionine metabolism Metabolic pathways Efferocytosis MicroRNAs in cancer PRC2 methylates histones and DNA RMTs methylate histone arginines +3 more

Ribosome biogenesis in eukaryotes Proteoglycans in cancer MicroRNA (miRNA) biogenesis

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway HIF-1 signaling pathway FoxO signaling pathway Phospholipase D signaling pathway Endocytosis PI3K-Akt signaling pathway Focal adhesion Adherens junction Gap junction JAK-STAT signaling pathway Regulation of actin cytoskeleton GnRH signaling pathway Estrogen signaling pathway Oxytocin signaling pathway Relaxin signaling pathway Parathyroid hormone synthesis, secretion and action Cushing syndrome Epithelial cell signaling in Helicobacter pylori infection Shigellosis Hepatitis C Human cytomegalovirus infection Human papillomavirus infection Coronavirus disease - COVID-19 Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Pancreatic cancer Endometrial cancer Glioma Prostate cancer Melanoma Bladder cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by ERBB4 SHC1 events in ERBB2 signaling PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Signal transduction by L1 Constitutive Signaling by EGFRvIII Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Extra-nuclear estrogen signaling NOTCH3 Activation and Transmission of Signal to the Nucleus HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants +79 more

Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events Transcription-Coupled Nucleotide Excision Repair (TC-NER) TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation +4 more

Cytoskeleton in muscle cells Protein digestion and absorption Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres +2 more

Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer EML4 and NUDC in mitotic spindle formation +1 more

Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells +1 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway HIF-1 signaling pathway PI3K-Akt signaling pathway Focal adhesion Adherens junction Tight junction Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Pancreatic cancer Endometrial cancer Prostate cancer Bladder cancer Non-small cell lung cancer Breast cancer Gastric cancer Central carbon metabolism in cancer Signaling by ERBB2 SHC1 events in ERBB2 signaling PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Sema4D induced cell migration and growth-cone collapse RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants +48 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Proteoglycans in cancer MicroRNAs in cancer Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants +19 more

MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Amyotrophic lateral sclerosis Proteoglycans in cancer Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 Downregulation of ERBB4 signaling PIP3 activates AKT signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Estrogen-dependent gene expression Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants +22 more

NF-kappa B signaling pathway

Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE +19 more

Nucleotide excision repair Fanconi anemia pathway HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway +4 more

Transcriptional misregulation in cancer Prostate cancer

Endocrine resistance Hormone signaling Estrogen signaling pathway Prolactin signaling pathway Thyroid hormone signaling pathway Endocrine and other factor-regulated calcium reabsorption Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - receptor activation Breast cancer Nuclear signaling by ERBB4 PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors RUNX1 regulates estrogen receptor mediated transcription ESR-mediated signaling RUNX1 regulates transcription of genes involved in WNT signaling Regulation of RUNX2 expression and activity Extra-nuclear estrogen signaling Estrogen-dependent gene expression +21 more

Transcriptional misregulation in cancer

Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways HS-GAG biosynthesis Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS +2 more

Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways HS-GAG biosynthesis Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS +2 more

Lysine degradation Metabolic pathways Polycomb repressive complex MicroRNAs in cancer PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events +7 more

Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes

Fanconi anemia pathway Fanconi Anemia Pathway