Adrenal cortex carcinoma

Efferocytosis Adherens junction JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway B cell receptor signaling pathway Pathogenic Escherichia coli infection Leishmaniasis Proteoglycans in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer GPVI-mediated activation cascade Regulation of KIT signaling PECAM1 interactions Costimulation by the CD28 family PD-1 signaling Platelet sensitization by LDL Interleukin-3, Interleukin-5 and GM-CSF signaling CD22 mediated BCR regulation Neutrophil degranulation Interferon gamma signaling Interleukin-37 signaling Interferon alpha/beta signaling Interleukin receptor SHC signaling Regulation of IFNA signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers +22 more

Adherens junction Neutrophil degranulation

Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules

Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint +3 more

Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Factors involved in megakaryocyte development and platelet production +4 more

Th17 cell differentiation Estrogen signaling pathway Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Signaling by Retinoic Acid Transcriptional regulation of granulopoiesis +6 more

MAPK signaling pathway Ras signaling pathway Axon guidance Downstream signal transduction EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases +5 more

Endocrine resistance Cell cycle Cellular senescence Cushing syndrome Hepatitis C Hepatitis B Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - receptor activation Pancreatic cancer Glioma Prostate cancer Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Inhibition of replication initiation of damaged DNA by RB1/E2F1 Condensation of Prophase Chromosomes Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry +30 more

MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Pathways in cancer Thyroid cancer Non-small cell lung cancer Central carbon metabolism in cancer RAF/MAP kinase cascade RET signaling +6 more

G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Leukocyte transendothelial migration Salmonella infection Rho GTPase cycle

Fanconi anemia pathway HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint +7 more

Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation

Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation

Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +7 more

MAPK signaling pathway Ras signaling pathway cAMP signaling pathway Phospholipase D signaling pathway Mitophagy - animal Autophagy - animal Cellular senescence Apelin signaling pathway C-type lectin receptor signaling pathway Regulation of actin cytoskeleton Proteoglycans in cancer +8 more

Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia

PPAR signaling pathway Efferocytosis PI3K-Akt signaling pathway Th17 cell differentiation Thyroid hormone signaling pathway Adipocytokine signaling pathway Parathyroid hormone synthesis, secretion and action Non-alcoholic fatty liver disease Bile secretion Hepatitis C Pathways in cancer Transcriptional misregulation in cancer Chemical carcinogenesis - receptor activation Thyroid cancer Small cell lung cancer Non-small cell lung cancer Gastric cancer Lipid and atherosclerosis RORA activates gene expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Carnitine metabolism Regulation of pyruvate dehydrogenase (PDH) complex Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock SUMOylation of intracellular receptors Signaling by Retinoic Acid NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose Transcriptional regulation of granulopoiesis NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis +39 more

Ribosome biogenesis in eukaryotes

Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways Carbon metabolism Thermogenesis Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Citric acid cycle (TCA cycle) +12 more

Bacterial invasion of epithelial cells Shigellosis

Lysine degradation Metabolic pathways PKMTs methylate histone lysines

Lysine degradation Metabolic pathways Signaling pathways regulating pluripotency of stem cells PKMTs methylate histone lysines +1 more

FoxO signaling pathway Efferocytosis mTOR signaling pathway PI3K-Akt signaling pathway Parathyroid hormone synthesis, secretion and action Aldosterone-regulated sodium reabsorption Stimuli-sensing channels Regulation of TP53 Degradation NGF-stimulated transcription +6 more

FoxO signaling pathway Hormone signaling Cell cycle Wnt signaling pathway TGF-beta signaling pathway Apelin signaling pathway Hippo signaling pathway Adherens junction Signaling pathways regulating pluripotency of stem cells Th17 cell differentiation AGE-RAGE signaling pathway in diabetic complications Hepatitis B Human T-cell leukemia virus 1 infection Pathways in cancer Colorectal cancer Pancreatic cancer Chronic myeloid leukemia Hepatocellular carcinoma Gastric cancer Signaling by NODAL Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of cell cycle genes +30 more

ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma Interleukin-7 signaling Formation of the beta-catenin:TCF transactivating complex RMTs methylate histone arginines Chromatin modifying enzymes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known EGR2 and SOX10-mediated initiation of Schwann cell myelination +6 more

ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis Hepatocellular carcinoma RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known +3 more

ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known +2 more

Cell cycle Oocyte meiosis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression +5 more

Hedgehog signaling pathway Axon guidance Pathways in cancer Proteoglycans in cancer Basal cell carcinoma Hedgehog 'off' state BBSome-mediated cargo-targeting to cilium Hedgehog 'on' state Activation of SMO +6 more

Ubiquitin mediated proteolysis Osteoclast differentiation JAK-STAT signaling pathway Insulin signaling pathway Prolactin signaling pathway Type II diabetes mellitus Growth hormone synthesis, secretion and action Toxoplasmosis MicroRNAs in cancer Interleukin-7 signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling Interferon alpha/beta signaling Antigen processing: Ubiquitination & Proteasome degradation +13 more

Notch signaling pathway

Hedgehog signaling pathway Hedgehog 'on' state

Spliceosome Amyotrophic lateral sclerosis Herpes simplex virus 1 infection Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination +4 more

ATP-dependent chromatin remodeling Transcriptional misregulation in cancer

FoxO signaling pathway Hormone signaling Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Tight junction Adipocytokine signaling pathway Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes +9 more

Wnt signaling pathway RORA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events +11 more

Signaling pathways regulating pluripotency of stem cells

Signaling pathways regulating pluripotency of stem cells Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs +2 more

Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer Hepatocellular carcinoma Gastric cancer Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex +4 more

Mitophagy - animal Transcriptional misregulation in cancer Renal cell carcinoma

MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway Endocytosis Cellular senescence TGF-beta signaling pathway Osteoclast differentiation Hippo signaling pathway Adherens junction Th17 cell differentiation Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Chagas disease Hepatitis B Human T-cell leukemia virus 1 infection Pathways in cancer Transcriptional misregulation in cancer Colorectal cancer Pancreatic cancer Chronic myeloid leukemia Hepatocellular carcinoma Gastric cancer Diabetic cardiomyopathy Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer +28 more

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Human papillomavirus infection MicroRNAs in cancer Integrin cell surface interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation +6 more