Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
acute leukemia of ambiguous lineage	MONDO_0019460	ABL1	Unknown	19579075 22708039 18455790 25692130 10567681 11853795 10998848 22226019	Open Targets	ErbB signaling pathway Ras signaling pathway Cell cycle +17 more
		AFF1	Unknown	8358709 19579075	Open Targets	Transcriptional misregulation in cancer
		ASXL1	Unknown	22581002	Open Targets	Polycomb repressive complex UCH proteinases
		BCOR	Unknown	31910380	Open Targets	Polycomb repressive complex
		BCORL1	Unknown	34301788	Open Targets	Polycomb repressive complex
		BCR	Unknown	19579075 22708039 18455790 25692130 10567681 10998848 22226019	Open Targets	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
		BRAF	Unknown	14603338	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		CBL	Unknown	34301788	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +22 more
		CCND3	Unknown	34301788	Open Targets	Cell cycle p53 signaling pathway PI3K-Akt signaling pathway +17 more
		CDH11	Unknown	15026324	Open Targets	Adherens junctions interactions
		CDKN2A	Unknown	7577621	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CEBPA	Unknown	18752591	Open Targets	Non-alcoholic fatty liver disease Pathways in cancer Transcriptional misregulation in cancer +3 more
		DNMT3A	Unknown	34301788	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		ETV6	Unknown	15229617 8751464	Open Targets	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
		EWSR1	Unknown	12359745	Open Targets	Transcriptional misregulation in cancer
		EZH2	Unknown	22581002 34301788	Open Targets	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		FLT3	Unknown	24959335 18373709 17805050 16076872 17581610 19052976 23412561 34301788 9737679 36042201 18394702 37254813 20890793 22038701	Open Targets	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		GPHN	Unknown	11579461	Open Targets	Folate biosynthesis Metabolic pathways Biosynthesis of cofactors +2 more
		IDH1	Unknown	31910380	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IKZF1	Unknown	22581002 22868967	Open Targets	—
		JAK1	Unknown	34301788	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAK2	Unknown	18328559 16531268 17581610 15805263 18661406 20852385	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAK3	Unknown	34301788	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		KIT	Unknown	21482694 20890793	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2A	Unknown	19579075 19380030 11579461 20920256 20299091 8358709	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	36042201	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LOC100506403	Unknown	24523240 8751464 31910380 17805050 34301788 17485549 21738341	Open Targets	—
		MLLT10	Unknown	20299091 19380030	Open Targets	—
		MN1	Unknown	15229617	Open Targets	—
		NF1	Unknown	36042201	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NOTCH1	Unknown	22581002	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NRAS	Unknown	34362951 2197591 36042201 9009246	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NUP214	Unknown	1384675 21679311 20682390	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism +26 more
		PBX1	Unknown	25692130 18455790 22226019	Open Targets	Efferocytosis Cortisol synthesis and secretion Cushing syndrome +3 more
		PCM1	Unknown	15805263	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +4 more
		PIK3CA	Unknown	36042201	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PTEN	Unknown	10706759	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		RUNX1T1	Unknown	21738341	Open Targets	Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia
		SET	Unknown	1384675 21679311 20682390	Open Targets	Condensation of Prophase Chromosomes HuR (ELAVL1) binds and stabilizes mRNA
		SMARCA4	Unknown	34301788	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		TCF3	Unknown	25692130 18455790 22226019	Open Targets	Signaling pathways regulating pluripotency of stem cells Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer +2 more
		TET2	Unknown	22581002	Open Targets	—
		TP53	Unknown	34301788	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		USP6	Unknown	15026324	Open Targets	—
		WT1	Unknown	23412561 34301788 9531607	Open Targets	Transcriptional misregulation in cancer
		ZNF384	Unknown	12359745	Open Targets	—

Acute leukemia of ambiguous lineage

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