Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

← Back to all clusters

Cluster 226

9 diseases · 17 shared-gene connections
9 Diseases
11 Unique genes
0.294 Avg. similarity score
Cerebral embolism Most-connected disease (5 links)
Log in to save this analysis

Save This Analysis

Disease Searched: Pregnancy loss, recurrent, 4 Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Cerebral embolism 5 5 1
Hypercalcemic tumoral calcinosis 5 5 3
Hyperphosphatemic tumoral calcinosis 5 5 3
Intracranial embolism 5 5 1
Tumoral calcinosis 5 5 4
Infertility 4 4 8
Hyperphosphatemic familial tumoral calcinosis 2 3 3 1
Pregnancy loss, recurrent, 4 1 1 1
Spermatogenic failure 5 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
KL 6 / 9 Cerebral embolism, Hypercalcemic tumoral calcinosis, Hyperphosphatemic tumoral calcinosis, Infertility and 2 more
FGF23 4 / 9 Hypercalcemic tumoral calcinosis, Hyperphosphatemic familial tumoral calcinosis 2, Hyperphosphatemic tumoral calcinosis, Tumoral calcinosis
GALNT3 3 / 9 Hypercalcemic tumoral calcinosis, Hyperphosphatemic tumoral calcinosis, Tumoral calcinosis
AURKC 2 / 9 Infertility, Spermatogenic failure 5
SYCP3 2 / 9 Infertility, Pregnancy loss, recurrent, 4
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
FGFR1c and Klotho ligand binding and activation
KL, FGF23
 Reactome 2 / 3 728× 2.29e-6 7.92e-5 ✓ sig.
FGFR3c ligand binding and activation
FGF23, GALNT3
 Reactome 2 / 13 168× 5.92e-5 1.15e-3 ✓ sig.
Phospholipase C-mediated cascade: FGFR1
KL, FGF23
 Reactome 2 / 16 136× 9.09e-5 1.63e-3 ✓ sig.
Downstream signaling of activated FGFR1
KL, FGF23
 Reactome 2 / 18 121× 1.16e-4 1.98e-3 ✓ sig.
PI-3K cascade:FGFR1
KL, FGF23
 Reactome 2 / 21 104× 1.59e-4 2.55e-3 ✓ sig.
SHC-mediated cascade:FGFR1
KL, FGF23
 Reactome 2 / 21 104× 1.59e-4 2.55e-3 ✓ sig.
FRS-mediated FGFR1 signaling
KL, FGF23
 Reactome 2 / 23 94.9× 1.91e-4 2.94e-3 ✓ sig.
Negative regulation of FGFR1 signaling
KL, FGF23
 Reactome 2 / 26 84.0× 2.45e-4 3.59e-3 ✓ sig.
PI3K Cascade
KL, FGF23
 Reactome 2 / 39 56.0× 5.55e-4 6.84e-3 ✓ sig.
Constitutive Signaling by Aberrant PI3K in Cancer
KL, FGF23
 Reactome 2 / 75 29.1× 2.04e-3 1.85e-2 ✓ sig.
Longevity regulating pathway
KL, EHMT2
 KEGG 2 / 90 24.3× 2.92e-3 2.40e-2 ✓ sig.
PIP3 activates AKT signaling
KL, FGF23
 Reactome 2 / 93 23.5× 3.12e-3 2.51e-2 ✓ sig.
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
KL, FGF23
 Reactome 2 / 103 21.2× 3.81e-3 2.89e-2 ✓ sig.
Parathyroid hormone synthesis, secretion and action
KL, FGF23
 KEGG 2 / 115 19.0× 4.72e-3 3.37e-2 ✓ sig.
RAF/MAP kinase cascade
KL, FGF23
 Reactome 2 / 124 17.6× 5.47e-3 3.72e-2 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
KL, FGF23
 GO:0090080 2 / 5 680× 3.15e-6 2.14e-4 ✓ sig.
fibroblast growth factor receptor signaling pathway
KL, FGF23, GALNT3
 GO:0008543 3 / 60 84.9× 5.10e-6 3.14e-4 ✓ sig.
energy reserve metabolic process
KL, LEPR
 GO:0006112 2 / 16 212× 3.76e-5 1.46e-3 ✓ sig.
meiotic cell cycle
AURKC, SPATA22, SYCP3
 GO:0051321 3 / 137 37.2× 6.09e-5 2.10e-3 ✓ sig.
calcium ion homeostasis
KL, FGF23
 GO:0055074 2 / 42 80.9× 2.68e-4 6.12e-3 ✓ sig.
fertilization
EHMT2, SPATA22
 GO:0009566 2 / 54 62.9× 4.43e-4 8.60e-3 ✓ sig.
positive regulation of vitamin D 24-hydroxylase activity
FGF23
 GO:0010980 1 / 1 1,699× 5.89e-4 1.04e-2 ✓ sig.
regulation of phosphate transport
FGF23
 GO:0010966 1 / 2 849× 1.18e-3 1.57e-2 ✓ sig.
phenotypic switching
EHMT2
 GO:0036166 1 / 2 849× 1.18e-3 1.57e-2 ✓ sig.
multicellular organism development
LEPR
 GO:0007275 1 / 2 849× 1.18e-3 1.57e-2 ✓ sig.
spermatocyte division
SPATA22
 GO:0048137 1 / 2 849× 1.18e-3 1.57e-2 ✓ sig.
cell division
TTC19, AURKC, SYCP3
 GO:0051301 3 / 406 12.6× 1.48e-3 1.79e-2 ✓ sig.
polysaccharide metabolic process
GALNT3
 GO:0005976 1 / 3 566× 1.76e-3 1.96e-2 ✓ sig.
meiotic DNA repair synthesis
SPATA22
 GO:0000711 1 / 3 566× 1.76e-3 1.96e-2 ✓ sig.
spermatid development
EHMT2, SYCP3
 GO:0007286 2 / 120 28.3× 2.17e-3 2.19e-2 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Hypercalcemic tumoral calcinosis Hyperphosphatemic tumoral calcinosis 0.750 3 1.62e-12 1.71e-11 ✓ sig.
Hyperphosphatemic tumoral calcinosis Tumoral calcinosis 0.600 3 6.46e-12 6.55e-11 ✓ sig.
Hypercalcemic tumoral calcinosis Tumoral calcinosis 0.600 3 6.46e-12 6.55e-11 ✓ sig.
Cerebral embolism Intracranial embolism 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Cerebral embolism Hyperphosphatemic tumoral calcinosis 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Hyperphosphatemic tumoral calcinosis Intracranial embolism 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Hyperphosphatemic familial tumoral calcinosis 2 Hyperphosphatemic tumoral calcinosis 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Hypercalcemic tumoral calcinosis Hyperphosphatemic familial tumoral calcinosis 2 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Hypercalcemic tumoral calcinosis Intracranial embolism 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Cerebral embolism Hypercalcemic tumoral calcinosis 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Hyperphosphatemic familial tumoral calcinosis 2 Tumoral calcinosis 0.200 1 2.58e-4 5.38e-4 ✓ sig.
Cerebral embolism Tumoral calcinosis 0.200 1 2.58e-4 5.38e-4 ✓ sig.
Intracranial embolism Tumoral calcinosis 0.200 1 2.58e-4 5.38e-4 ✓ sig.
Cerebral embolism Infertility 0.111 1 5.17e-4 9.13e-4 ✓ sig.
Infertility Intracranial embolism 0.111 1 5.17e-4 9.13e-4 ✓ sig.
Infertility Pregnancy loss, recurrent, 4 0.111 1 5.17e-4 9.13e-4 ✓ sig.
Infertility Spermatogenic failure 5 0.111 1 5.17e-4 9.13e-4 ✓ sig.