Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 172
9
Diseases
22
Unique genes
0.209
Avg. similarity score
Congenital diarrhea
Most-connected disease (5 links)
Disease
Searched: Congenital secretory diarrhea
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Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details ·
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Congenital secretory diarrhea
Congenital diarrhea
Congenital sodium diarrhea
Chronic infantile diarrhea due to guanylate cyclase 2c overactivity
Duodenal atresia
Intestinal obstruction
Congenital chloride diarrhea
Congenital chronic diarrhea with protein-losing enteropathy
Cystic fibrosis-related diabetes
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Congenital diarrhea | 5 | 5 | 5 |
| Congenital secretory diarrhea | 5 | 5 | 4 |
| Congenital sodium diarrhea | 5 | 5 | 2 |
| Chronic infantile diarrhea due to guanylate cyclase 2c overactivity | 4 | 4 | 1 |
| Duodenal atresia | 4 | 4 | 1 |
| Intestinal obstruction | 4 | 4 | 12 |
| Congenital chloride diarrhea | 3 | 3 | 4 |
| Congenital chronic diarrhea with protein-losing enteropathy | 1 | 1 | 2 |
| Cystic fibrosis-related diabetes | 1 | 1 | 3 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| GUCY2C | 5 / 9 | Chronic infantile diarrhea due to guanylate cyclase 2c overactivity, Congenital diarrhea, Congenital secretory diarrhea, Congenital sodium diarrhea and 1 more |
| SLC26A3 | 3 / 9 | Congenital chloride diarrhea, Congenital secretory diarrhea, Intestinal obstruction |
| SLC9A3 | 3 / 9 | Congenital secretory diarrhea, Congenital sodium diarrhea, Intestinal obstruction |
| DGAT1 | 2 / 9 | Congenital chronic diarrhea with protein-losing enteropathy, Congenital diarrhea |
| GRWD1 | 2 / 9 | Congenital chloride diarrhea, Congenital diarrhea |
| PLVAP | 2 / 9 | Congenital chronic diarrhea with protein-losing enteropathy, Congenital diarrhea |
| SLC26A9 | 2 / 9 | Cystic fibrosis-related diabetes, Intestinal obstruction |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Multifunctional anion exchangers | Reactome | 2 / 9 | 121× | 1.14e-4 | 2.43e-3 ✓ sig. |
| Mineral absorption | KEGG | 3 / 61 | 26.8× | 1.79e-4 | 3.48e-3 ✓ sig. |
| Variant SLC6A14 may confer susceptibility towards obesity | Reactome | 1 / 1 | 546× | 1.83e-3 | 2.14e-2 ✓ sig. |
| Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) | Reactome | 1 / 1 | 546× | 1.83e-3 | 2.14e-2 ✓ sig. |
| Intestinal infectious diseases | Reactome | 1 / 2 | 273× | 3.66e-3 | 3.53e-2 ✓ sig. |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | Reactome | 1 / 3 | 182× | 5.49e-3 | 4.65e-2 ✓ sig. |
| Response of EIF2AK1 (HRI) to heme deficiency | Reactome | 1 / 3 | 182× | 5.49e-3 | 4.65e-2 ✓ sig. |
| Signaling by MST1 | Reactome | 1 / 5 | 109× | 9.13e-3 | 6.54e-2 |
| GRB7 events in ERBB2 signaling | Reactome | 1 / 5 | 109× | 9.13e-3 | 6.54e-2 |
| Digestion | Reactome | 1 / 5 | 109× | 9.13e-3 | 6.54e-2 |
| MET Receptor Activation | Reactome | 1 / 6 | 91.0× | 1.09e-2 | 7.34e-2 |
| RAB GEFs exchange GTP for GDP on RABs | Reactome | 2 / 90 | 12.1× | 1.16e-2 | 7.61e-2 |
| Acyl chain remodeling of DAG and TAG | Reactome | 1 / 7 | 78.0× | 1.28e-2 | 8.05e-2 |
| Mitophagy - animal | KEGG | 2 / 105 | 10.4× | 1.56e-2 | 9.10e-2 |
| Sodium/Proton exchangers | Reactome | 1 / 9 | 60.7× | 1.64e-2 | 9.37e-2 |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| oxalate transport | GO:0019532 | 2 / 11 | 154× | 7.23e-5 | 2.38e-3 ✓ sig. |
| sulfate transmembrane transport | GO:1902358 | 2 / 16 | 106× | 1.57e-4 | 4.26e-3 ✓ sig. |
| monoatomic anion transport | GO:0006820 | 2 / 19 | 89.4× | 2.24e-4 | 5.45e-3 ✓ sig. |
| positive regulation of gene expression | GO:0010628 | 5 / 504 | 8.4× | 2.52e-4 | 5.95e-3 ✓ sig. |
| regulation of membrane repolarization during atrial cardiac muscle cell action potential | GO:1905000 | 1 / 1 | 849× | 1.18e-3 | 1.67e-2 ✓ sig. |
| regulation of membrane repolarization during cardiac muscle cell action potential | GO:1905031 | 1 / 1 | 849× | 1.18e-3 | 1.67e-2 ✓ sig. |
| negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I | GO:1904283 | 1 / 1 | 849× | 1.18e-3 | 1.67e-2 ✓ sig. |
| positive regulation of cardiac muscle tissue development | GO:0055025 | 1 / 2 | 425× | 2.35e-3 | 2.52e-2 ✓ sig. |
| regulation of iron ion transport | GO:0034756 | 1 / 2 | 425× | 2.35e-3 | 2.52e-2 ✓ sig. |
| regulation of T cell mediated immunity | GO:0002709 | 1 / 2 | 425× | 2.35e-3 | 2.52e-2 ✓ sig. |
| beta-alanine transport | GO:0001762 | 1 / 2 | 425× | 2.35e-3 | 2.52e-2 ✓ sig. |
| vesicle localization | GO:0051648 | 1 / 2 | 425× | 2.35e-3 | 2.52e-2 ✓ sig. |
| aromatic amino acid transport | GO:0015801 | 1 / 2 | 425× | 2.35e-3 | 2.52e-2 ✓ sig. |
| granuloma formation | GO:0002432 | 1 / 2 | 425× | 2.35e-3 | 2.52e-2 ✓ sig. |
| pyrimidine nucleobase metabolic process | GO:0006206 | 1 / 2 | 425× | 2.35e-3 | 2.52e-2 ✓ sig. |