Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 632
5
Diseases
1
Unique genes
0.500
Avg. similarity score
Erythrocyte lactate transporter defect
Most-connected disease (4 links)
Disease
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Erythrocyte lactate transporter defect
Fatty acid and ketone body metabolism disorder
Fatty acid oxidation and ketone body metabolism disorder
Monocarboxylate transporter 1 deficiency
Symptomatic deficiency in lactate transport
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Erythrocyte lactate transporter defect | 4 | 4 | 1 |
| Fatty acid and ketone body metabolism disorder | 4 | 4 | 1 |
| Fatty acid oxidation and ketone body metabolism disorder | 4 | 4 | 1 |
| Monocarboxylate transporter 1 deficiency | 4 | 4 | 1 |
| Symptomatic deficiency in lactate transport | 4 | 4 | 1 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| SLC16A1 | 5 / 5 | Erythrocyte lactate transporter defect, Fatty acid and ketone body metabolism disorder, Fatty acid oxidation and ketone body metabolism disorder, Monocarboxylate transporter 1 deficiency and 1 more |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | Reactome | 1 / 2 | 6,005× | 1.67e-4 | 2.84e-3 ✓ sig. |
| Proton-coupled monocarboxylate transport | Reactome | 1 / 6 | 2,002× | 5.00e-4 | 6.67e-3 ✓ sig. |
| Pyruvate metabolism | Reactome | 1 / 19 | 632× | 1.58e-3 | 1.60e-2 ✓ sig. |
| Basigin interactions | Reactome | 1 / 25 | 480× | 2.08e-3 | 1.96e-2 ✓ sig. |
| Efferocytosis | KEGG | 1 / 157 | 76.5× | 1.31e-2 | 6.68e-2 |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| mevalonate transport | GO:0015728 | 1 / 1 | 18,687× | 5.35e-5 | 1.94e-3 ✓ sig. |
| behavioral response to nutrient | GO:0051780 | 1 / 1 | 18,687× | 5.35e-5 | 1.94e-3 ✓ sig. |
| plasma membrane lactate transport | GO:0035879 | 1 / 4 | 4,672× | 2.14e-4 | 5.31e-3 ✓ sig. |
| pyruvate transmembrane transport | GO:1901475 | 1 / 4 | 4,672× | 2.14e-4 | 5.31e-3 ✓ sig. |
| succinate transmembrane transport | GO:0071422 | 1 / 5 | 3,737× | 2.68e-4 | 6.25e-3 ✓ sig. |
| lactate transmembrane transport | GO:0035873 | 1 / 6 | 3,115× | 3.21e-4 | 7.04e-3 ✓ sig. |
| pyruvate catabolic process | GO:0042867 | 1 / 8 | 2,336× | 4.28e-4 | 8.53e-3 ✓ sig. |
| carboxylic acid transmembrane transport | GO:1905039 | 1 / 10 | 1,869× | 5.35e-4 | 9.88e-3 ✓ sig. |
| monocarboxylic acid transport | GO:0015718 | 1 / 17 | 1,099× | 9.10e-4 | 1.39e-2 ✓ sig. |
| response to food | GO:0032094 | 1 / 33 | 566× | 1.77e-3 | 1.99e-2 ✓ sig. |
| regulation of insulin secretion | GO:0050796 | 1 / 46 | 406× | 2.46e-3 | 2.36e-2 ✓ sig. |
| centrosome cycle | GO:0007098 | 1 / 49 | 381× | 2.62e-3 | 2.44e-2 ✓ sig. |
| transport across blood-brain barrier | GO:0150104 | 1 / 85 | 220× | 4.55e-3 | 3.20e-2 ✓ sig. |
| glucose homeostasis | GO:0042593 | 1 / 134 | 139× | 7.17e-3 | 3.98e-2 ✓ sig. |
| proton transmembrane transport | GO:1902600 | 1 / 181 | 103× | 9.69e-3 | 4.58e-2 ✓ sig. |