Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
← Back to all clusters
Cluster 615
5
Diseases
7
Unique genes
0.200
Avg. similarity score
Recurrent infections
Most-connected disease (4 links)
Disease
Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details ·
click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) ·
drag a node to pin it in place · scroll/pinch to zoom.
Recurrent infections
Hyper-immunoglobulin e recurrent infection syndrome 5, autosomal recessive
Interleukin 6 quantitative trait
Immunodeficiency 53
Immunodeficiency, common variable, 5
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Recurrent infections | 4 | 4 | 7 |
| Hyper-immunoglobulin e recurrent infection syndrome 5, autosomal recessive | 2 | 2 | 1 |
| Interleukin 6 quantitative trait | 2 | 2 | 1 |
| Immunodeficiency 53 | 1 | 1 | 1 |
| Immunodeficiency, common variable, 5 | 1 | 1 | 1 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| IL6R | 3 / 5 | Hyper-immunoglobulin e recurrent infection syndrome 5, autosomal recessive, Interleukin 6 quantitative trait, Recurrent infections |
| MS4A1 | 2 / 5 | Immunodeficiency, common variable, 5, Recurrent infections |
| RELB | 2 / 5 | Immunodeficiency 53, Recurrent infections |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| MAPK1 (ERK2) activation | Reactome | 2 / 9 | 381× | 1.05e-5 | 3.02e-4 ✓ sig. |
| MAPK3 (ERK1) activation | Reactome | 2 / 10 | 343× | 1.31e-5 | 3.64e-4 ✓ sig. |
| Interleukin-6 signaling | Reactome | 2 / 11 | 312× | 1.60e-5 | 4.32e-4 ✓ sig. |
| Hematopoietic cell lineage | KEGG | 3 / 100 | 51.5× | 1.91e-5 | 5.02e-4 ✓ sig. |
| Coronavirus disease - COVID-19 | KEGG | 3 / 238 | 21.6× | 2.54e-4 | 3.95e-3 ✓ sig. |
| Viral protein interaction with cytokine and cytokine receptor | KEGG | 2 / 100 | 34.3× | 1.40e-3 | 1.46e-2 ✓ sig. |
| Th17 cell differentiation | KEGG | 2 / 109 | 31.5× | 1.66e-3 | 1.66e-2 ✓ sig. |
| JAK-STAT signaling pathway | KEGG | 2 / 168 | 20.4× | 3.90e-3 | 3.08e-2 ✓ sig. |
| Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | Reactome | 1 / 7 | 245× | 4.07e-3 | 3.17e-2 ✓ sig. |
| TNF signaling | Reactome | 1 / 7 | 245× | 4.07e-3 | 3.17e-2 ✓ sig. |
| CD163 mediating an anti-inflammatory response | Reactome | 1 / 9 | 191× | 5.24e-3 | 3.76e-2 ✓ sig. |
| Epstein-Barr virus infection | KEGG | 2 / 204 | 16.8× | 5.70e-3 | 3.98e-2 ✓ sig. |
| Interleukin-27 signaling | Reactome | 1 / 11 | 156× | 6.40e-3 | 4.28e-2 ✓ sig. |
| Regulated proteolysis of p75NTR | Reactome | 1 / 11 | 156× | 6.40e-3 | 4.28e-2 ✓ sig. |
| Interleukin-35 Signalling | Reactome | 1 / 12 | 143× | 6.97e-3 | 4.53e-2 ✓ sig. |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| response to cytokine | GO:0034097 | 3 / 56 | 143× | 8.85e-7 | 7.75e-5 ✓ sig. |
| ciliary neurotrophic factor-mediated signaling pathway | GO:0070120 | 2 / 5 | 1,068× | 1.20e-6 | 9.99e-5 ✓ sig. |
| interleukin-11-mediated signaling pathway | GO:0038154 | 2 / 7 | 763× | 2.52e-6 | 1.83e-4 ✓ sig. |
| B cell differentiation | GO:0030183 | 3 / 80 | 100× | 2.61e-6 | 1.88e-4 ✓ sig. |
| neutrophil mediated immunity | GO:0002446 | 2 / 11 | 485× | 6.60e-6 | 3.94e-4 ✓ sig. |
| positive regulation of leukocyte chemotaxis | GO:0002690 | 2 / 13 | 411× | 9.36e-6 | 5.17e-4 ✓ sig. |
| T-helper 17 cell lineage commitment | GO:0072540 | 2 / 13 | 411× | 9.36e-6 | 5.17e-4 ✓ sig. |
| positive regulation of platelet aggregation | GO:1901731 | 2 / 13 | 411× | 9.36e-6 | 5.17e-4 ✓ sig. |
| interleukin-6-mediated signaling pathway | GO:0070102 | 2 / 16 | 334× | 1.44e-5 | 7.22e-4 ✓ sig. |
| cell surface receptor signaling pathway via STAT | GO:0097696 | 2 / 28 | 191× | 4.53e-5 | 1.71e-3 ✓ sig. |
| B cell proliferation | GO:0042100 | 2 / 38 | 141× | 8.40e-5 | 2.72e-3 ✓ sig. |
| B cell activation | GO:0042113 | 2 / 44 | 121× | 1.13e-4 | 3.38e-3 ✓ sig. |
| positive regulation of chemokine production | GO:0032722 | 2 / 49 | 109× | 1.40e-4 | 3.94e-3 ✓ sig. |
| cell surface receptor signaling pathway via JAK-STAT | GO:0007259 | 2 / 67 | 79.7× | 2.63e-4 | 6.18e-3 ✓ sig. |
| positive regulation of osteoblast differentiation | GO:0045669 | 2 / 78 | 68.5× | 3.56e-4 | 7.58e-3 ✓ sig. |
Pairs within this cluster, by significance
| Disease A ⇵ | Disease B ⇵ | Similarity score ⇵ | Shared genes ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Hyper-immunoglobulin e recurrent infection syndrome 5, autosomal recessive | Interleukin 6 quantitative trait | 0.500 | 1 | 6.46e-5 | 1.98e-4 ✓ sig. |
| Hyper-immunoglobulin e recurrent infection syndrome 5, autosomal recessive | Recurrent infections | 0.125 | 1 | 4.52e-4 | 8.26e-4 ✓ sig. |
| Immunodeficiency 53 | Recurrent infections | 0.125 | 1 | 4.52e-4 | 8.26e-4 ✓ sig. |
| Immunodeficiency, common variable, 5 | Recurrent infections | 0.125 | 1 | 4.52e-4 | 8.26e-4 ✓ sig. |
| Interleukin 6 quantitative trait | Recurrent infections | 0.125 | 1 | 4.52e-4 | 8.26e-4 ✓ sig. |