Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 589

5 diseases · 10 shared-gene connections
5 Diseases
3 Unique genes
0.400 Avg. similarity score
Brooke-spiegler syndrome Most-connected disease (4 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Brooke-spiegler syndrome 4 4 1
Familial cylindromatosis 4 4 1
Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 4 4 1
Multiple familial trichoepithelioma 4 4 1
Trichoblastoma 4 4 3

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
CYLD 5 / 5 Brooke-spiegler syndrome, Familial cylindromatosis, Frontotemporal dementia and/or amyotrophic lateral sclerosis 8, Multiple familial trichoepithelioma and 1 more
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Thyroid cancer
HRAS, CTNNB1
 KEGG 2 / 37 216× 2.77e-5 6.79e-4 ✓ sig.
Endometrial cancer
HRAS, CTNNB1
 KEGG 2 / 59 136× 7.10e-5 1.44e-3 ✓ sig.
Colorectal cancer
HRAS, CTNNB1
 KEGG 2 / 87 92.0× 1.55e-4 2.68e-3 ✓ sig.
Prostate cancer
HRAS, CTNNB1
 KEGG 2 / 98 81.7× 1.97e-4 3.24e-3 ✓ sig.
Melanogenesis
HRAS, CTNNB1
 KEGG 2 / 101 79.3× 2.09e-4 3.40e-3 ✓ sig.
C-type lectin receptor signaling pathway
CYLD, HRAS
 KEGG 2 / 105 76.3× 2.26e-4 3.62e-3 ✓ sig.
Thyroid hormone signaling pathway
HRAS, CTNNB1
 KEGG 2 / 122 65.6× 3.05e-4 4.57e-3 ✓ sig.
Signaling pathways regulating pluripotency of stem cells
HRAS, CTNNB1
 KEGG 2 / 144 55.6× 4.25e-4 5.89e-3 ✓ sig.
Breast cancer
HRAS, CTNNB1
 KEGG 2 / 148 54.1× 4.49e-4 6.14e-3 ✓ sig.
Gastric cancer
HRAS, CTNNB1
 KEGG 2 / 150 53.4× 4.61e-4 6.28e-3 ✓ sig.
Hepatitis C
HRAS, CTNNB1
 KEGG 2 / 159 50.4× 5.18e-4 6.85e-3 ✓ sig.
Hepatocellular carcinoma
HRAS, CTNNB1
 KEGG 2 / 170 47.1× 5.92e-4 7.61e-3 ✓ sig.
RAS GTPase cycle mutants
HRAS
 Reactome 1 / 3 1,334× 7.49e-4 9.09e-3 ✓ sig.
Kaposi sarcoma-associated herpesvirus infection
HRAS, CTNNB1
 KEGG 2 / 196 40.9× 7.86e-4 9.43e-3 ✓ sig.
Focal adhesion
HRAS, CTNNB1
 KEGG 2 / 203 39.4× 8.43e-4 9.95e-3 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
glial cell fate determination
CTNNB1
 GO:0007403 1 / 1 6,229× 1.61e-4 4.34e-3 ✓ sig.
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
CTNNB1
 GO:0044338 1 / 1 6,229× 1.61e-4 4.34e-3 ✓ sig.
lung cell differentiation
CTNNB1
 GO:0060479 1 / 1 6,229× 1.61e-4 4.34e-3 ✓ sig.
cranial ganglion development
CTNNB1
 GO:0061550 1 / 1 6,229× 1.61e-4 4.34e-3 ✓ sig.
negative regulation of interleukin-18-mediated signaling pathway
CYLD
 GO:2000493 1 / 1 6,229× 1.61e-4 4.34e-3 ✓ sig.
MAPK cascade
HRAS, CTNNB1
 GO:0000165 2 / 147 84.7× 1.83e-4 4.78e-3 ✓ sig.
negative regulation of canonical Wnt signaling pathway
CYLD, CTNNB1
 GO:0090090 2 / 150 83.1× 1.91e-4 4.93e-3 ✓ sig.
negative regulation of neuron apoptotic process
HRAS, CTNNB1
 GO:0043524 2 / 160 77.9× 2.17e-4 5.38e-3 ✓ sig.
positive regulation of branching involved in lung morphogenesis
CTNNB1
 GO:0061047 1 / 2 3,115× 3.21e-4 7.04e-3 ✓ sig.
neural plate development
CTNNB1
 GO:0001840 1 / 2 3,115× 3.21e-4 7.04e-3 ✓ sig.
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
CTNNB1
 GO:0003340 1 / 2 3,115× 3.21e-4 7.04e-3 ✓ sig.
regulation of centriole-centriole cohesion
CTNNB1
 GO:0030997 1 / 2 3,115× 3.21e-4 7.04e-3 ✓ sig.
negative regulation of mitotic cell cycle, embryonic
CTNNB1
 GO:0045976 1 / 2 3,115× 3.21e-4 7.04e-3 ✓ sig.
regulation of timing of anagen
CTNNB1
 GO:0051884 1 / 2 3,115× 3.21e-4 7.04e-3 ✓ sig.
renal vesicle formation
CTNNB1
 GO:0072033 1 / 2 3,115× 3.21e-4 7.04e-3 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Brooke-spiegler syndrome Familial cylindromatosis 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Brooke-spiegler syndrome Multiple familial trichoepithelioma 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Brooke-spiegler syndrome Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Familial cylindromatosis Multiple familial trichoepithelioma 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Familial cylindromatosis Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 Multiple familial trichoepithelioma 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Brooke-spiegler syndrome Trichoblastoma 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Familial cylindromatosis Trichoblastoma 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 Trichoblastoma 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Multiple familial trichoepithelioma Trichoblastoma 0.250 1 1.94e-4 4.41e-4 ✓ sig.