Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 509
6
Diseases
3
Unique genes
0.341
Avg. similarity score
Glutaric aciduria
Most-connected disease (5 links)
Disease
Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details ·
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Glutaric aciduria
Multiple acyl-CoA dehydrogenase deficiency
Glutaric acidemia iib
Glutaric acidemia iic
Glutaric aciduria 2b
Glutaric aciduria 2c
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Glutaric aciduria | 5 | 5 | 3 |
| Multiple acyl-CoA dehydrogenase deficiency | 5 | 5 | 3 |
| Glutaric acidemia iib | 3 | 3 | 1 |
| Glutaric acidemia iic | 3 | 3 | 1 |
| Glutaric aciduria 2b | 3 | 3 | 1 |
| Glutaric aciduria 2c | 3 | 3 | 1 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| ETFB | 4 / 6 | Glutaric acidemia iib, Glutaric aciduria, Glutaric aciduria 2b, Multiple acyl-CoA dehydrogenase deficiency |
| ETFDH | 4 / 6 | Glutaric acidemia iic, Glutaric aciduria, Glutaric aciduria 2c, Multiple acyl-CoA dehydrogenase deficiency |
| ETFA | 2 / 6 | Glutaric aciduria, Multiple acyl-CoA dehydrogenase deficiency |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Respiratory electron transport | Reactome | 3 / 83 | 145× | 3.18e-7 | 1.54e-5 ✓ sig. |
| Protein methylation | Reactome | 1 / 19 | 211× | 4.74e-3 | 3.52e-2 ✓ sig. |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| fatty acid beta-oxidation using acyl-CoA dehydrogenase | GO:0033539 | 3 / 11 | 1,699× | 1.52e-10 | 4.43e-8 ✓ sig. |
| respiratory electron transport chain | GO:0022904 | 3 / 23 | 812× | 1.63e-9 | 3.55e-7 ✓ sig. |
| amino acid catabolic process | GO:0009063 | 2 / 5 | 2,492× | 1.72e-7 | 1.99e-5 ✓ sig. |
| electron transport chain | GO:0022900 | 1 / 16 | 389× | 2.57e-3 | 2.40e-2 ✓ sig. |
| response to oxidative stress | GO:0006979 | 1 / 146 | 42.7× | 2.33e-2 | 7.07e-2 |
Pairs within this cluster, by significance
| Disease A ⇵ | Disease B ⇵ | Similarity score ⇵ | Shared genes ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Glutaric aciduria | Multiple acyl-CoA dehydrogenase deficiency | 0.750 | 3 | 1.62e-12 | 1.71e-11 ✓ sig. |
| Glutaric acidemia iib | Glutaric aciduria 2b | 0.500 | 1 | 6.46e-5 | 1.98e-4 ✓ sig. |
| Glutaric acidemia iic | Glutaric aciduria 2c | 0.500 | 1 | 6.46e-5 | 1.98e-4 ✓ sig. |
| Glutaric acidemia iib | Multiple acyl-CoA dehydrogenase deficiency | 0.250 | 1 | 1.94e-4 | 4.41e-4 ✓ sig. |
| Glutaric acidemia iib | Glutaric aciduria | 0.250 | 1 | 1.94e-4 | 4.41e-4 ✓ sig. |
| Glutaric acidemia iic | Multiple acyl-CoA dehydrogenase deficiency | 0.250 | 1 | 1.94e-4 | 4.41e-4 ✓ sig. |
| Glutaric acidemia iic | Glutaric aciduria | 0.250 | 1 | 1.94e-4 | 4.41e-4 ✓ sig. |
| Glutaric aciduria | Glutaric aciduria 2b | 0.250 | 1 | 1.94e-4 | 4.41e-4 ✓ sig. |
| Glutaric aciduria 2b | Multiple acyl-CoA dehydrogenase deficiency | 0.250 | 1 | 1.94e-4 | 4.41e-4 ✓ sig. |
| Glutaric aciduria 2c | Multiple acyl-CoA dehydrogenase deficiency | 0.250 | 1 | 1.94e-4 | 4.41e-4 ✓ sig. |
| Glutaric aciduria | Glutaric aciduria 2c | 0.250 | 1 | 1.94e-4 | 4.41e-4 ✓ sig. |