Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 508

6 diseases · 15 shared-gene connections
6 Diseases
2 Unique genes
0.444 Avg. similarity score
Genetic hyperferritinemia without iron overload Most-connected disease (5 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Genetic hyperferritinemia without iron overload 5 5 1
Hereditary hyperferritinemia with congenital cataracts 5 5 1
Hyperferritinemia 5 5 2
Hyperferritinemia with or without cataract 5 5 1
L-ferritin deficiency 5 5 1
Neuroferritinopathy 5 5 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
FTL 6 / 6 Genetic hyperferritinemia without iron overload, Hereditary hyperferritinemia with congenital cataracts, Hyperferritinemia, Hyperferritinemia with or without cataract and 2 more
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Scavenging by Class H Receptors
STAB1
 Reactome 1 / 4 1,501× 6.66e-4 8.31e-3 ✓ sig.
Iron uptake and transport
FTL
 Reactome 1 / 28 214× 4.66e-3 3.48e-2 ✓ sig.
Ferroptosis
FTL
 KEGG 1 / 42 143× 6.98e-3 4.53e-2 ✓ sig.
Porphyrin metabolism
FTL
 KEGG 1 / 46 131× 7.65e-3 4.81e-2 ✓ sig.
Golgi Associated Vesicle Biogenesis
FTL
 Reactome 1 / 56 107× 9.30e-3 5.43e-2
Mineral absorption
FTL
 KEGG 1 / 61 98.4× 1.01e-2 5.73e-2
Efferocytosis
STAB1
 KEGG 1 / 157 38.2× 2.60e-2 9.97e-2
Necroptosis
FTL
 KEGG 1 / 159 37.8× 2.63e-2 1.00e-1
Neutrophil degranulation
FTL
 Reactome 1 / 480 12.5× 7.83e-2 1.87e-1

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
iron ion transport
FTL
 GO:0006826 1 / 31 301× 3.32e-3 2.75e-2 ✓ sig.
intracellular iron ion homeostasis
FTL
 GO:0006879 1 / 71 132× 7.58e-3 4.08e-2 ✓ sig.
receptor-mediated endocytosis
STAB1
 GO:0006898 1 / 80 117× 8.54e-3 4.31e-2 ✓ sig.
negative regulation of angiogenesis
STAB1
 GO:0016525 1 / 133 70.3× 1.42e-2 5.50e-2
defense response to bacterium
STAB1
 GO:0042742 1 / 214 43.7× 2.28e-2 6.98e-2
endocytosis
STAB1
 GO:0006897 1 / 223 41.9× 2.37e-2 7.14e-2
cell-cell signaling
STAB1
 GO:0007267 1 / 234 39.9× 2.49e-2 7.33e-2
inflammatory response
STAB1
 GO:0006954 1 / 467 20.0× 4.94e-2 1.07e-1
cell adhesion
STAB1
 GO:0007155 1 / 665 14.1× 6.99e-2 1.31e-1

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Genetic hyperferritinemia without iron overload Hereditary hyperferritinemia with congenital cataracts 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Genetic hyperferritinemia without iron overload Neuroferritinopathy 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Genetic hyperferritinemia without iron overload Hyperferritinemia with or without cataract 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Genetic hyperferritinemia without iron overload L-ferritin deficiency 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Hereditary hyperferritinemia with congenital cataracts Neuroferritinopathy 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Hereditary hyperferritinemia with congenital cataracts Hyperferritinemia with or without cataract 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Hereditary hyperferritinemia with congenital cataracts L-ferritin deficiency 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Hyperferritinemia with or without cataract Neuroferritinopathy 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Hyperferritinemia with or without cataract L-ferritin deficiency 0.500 1 6.46e-5 1.98e-4 ✓ sig.
L-ferritin deficiency Neuroferritinopathy 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Genetic hyperferritinemia without iron overload Hyperferritinemia 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Hereditary hyperferritinemia with congenital cataracts Hyperferritinemia 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Hyperferritinemia Neuroferritinopathy 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Hyperferritinemia Hyperferritinemia with or without cataract 0.333 1 1.29e-4 3.27e-4 ✓ sig.
Hyperferritinemia L-ferritin deficiency 0.333 1 1.29e-4 3.27e-4 ✓ sig.