Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 501

6 diseases · 11 shared-gene connections
6 Diseases
3 Unique genes
0.386 Avg. similarity score
Pseudohypoaldosteronism Most-connected disease (5 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Pseudohypoaldosteronism 5 5 3
Early-onset hypertension with severe exacerbation in pregnancy 4 4 1
Pseudohyperaldosteronism type 2 4 4 1
Pseudohypoaldosteronism 1, autosomal dominant 4 4 1
Pseudohypoaldosteronism type i, autosomal dominant 4 4 1
Pseudohypoaldosteronism, type iib 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
NR3C2 5 / 6 Early-onset hypertension with severe exacerbation in pregnancy, Pseudohyperaldosteronism type 2, Pseudohypoaldosteronism, Pseudohypoaldosteronism 1, autosomal dominant and 1 more
WNK4 2 / 6 Pseudohypoaldosteronism, Pseudohypoaldosteronism, type iib
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Stimuli-sensing channels
WNK4, WNK1
 Reactome 2 / 79 101× 1.28e-4 2.30e-3 ✓ sig.
Parathyroid hormone synthesis, secretion and action
WNK4, WNK1
 KEGG 2 / 115 69.6× 2.71e-4 4.17e-3 ✓ sig.
SUMOylation of intracellular receptors
NR3C2
 Reactome 1 / 27 148× 6.73e-3 4.43e-2 ✓ sig.
Aldosterone-regulated sodium reabsorption
NR3C2
 KEGG 1 / 38 105× 9.46e-3 5.49e-2
Nuclear Receptor transcription pathway
NR3C2
 Reactome 1 / 52 77.0× 1.29e-2 6.63e-2
HSP90 chaperone cycle for steroid hormone receptors (SHR)
NR3C2
 Reactome 1 / 55 72.8× 1.37e-2 6.87e-2

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
negative regulation of sodium ion transport
WNK4, WNK1
 GO:0010766 2 / 5 2,492× 1.72e-7 1.99e-5 ✓ sig.
negative regulation of pancreatic juice secretion
WNK4, WNK1
 GO:0090188 2 / 5 2,492× 1.72e-7 1.99e-5 ✓ sig.
intracellular chloride ion homeostasis
WNK4, WNK1
 GO:0030644 2 / 10 1,246× 7.73e-7 6.94e-5 ✓ sig.
homeostatic process
WNK4, WNK1
 GO:0042592 2 / 19 656× 2.94e-6 2.06e-4 ✓ sig.
negative regulation of protein localization to plasma membrane
WNK4, WNK1
 GO:1903077 2 / 25 498× 5.15e-6 3.25e-4 ✓ sig.
regulation of blood pressure
WNK4, WNK1
 GO:0008217 2 / 83 150× 5.83e-5 2.07e-3 ✓ sig.
sodium ion transmembrane transport
WNK4, WNK1
 GO:0035725 2 / 134 93.0× 1.52e-4 4.19e-3 ✓ sig.
positive regulation of termination of RNA polymerase II transcription
WNK1
 GO:1904595 1 / 1 6,229× 1.61e-4 4.34e-3 ✓ sig.
aldosterone secretion
WNK4
 GO:0035932 1 / 1 6,229× 1.61e-4 4.34e-3 ✓ sig.
potassium ion transmembrane transport
WNK4, WNK1
 GO:0071805 2 / 150 83.1× 1.91e-4 4.93e-3 ✓ sig.
distal tubule morphogenesis
WNK4
 GO:0072156 1 / 2 3,115× 3.21e-4 7.04e-3 ✓ sig.
negative regulation of cell-cell adhesion mediated by integrin
WNK1
 GO:0033633 1 / 2 3,115× 3.21e-4 7.04e-3 ✓ sig.
chemokine (C-C motif) ligand 21 signaling pathway
WNK1
 GO:0038116 1 / 3 2,076× 4.82e-4 9.24e-3 ✓ sig.
regulation of potassium ion export across plasma membrane
WNK4
 GO:1903764 1 / 3 2,076× 4.82e-4 9.24e-3 ✓ sig.
protein phosphorylation
WNK4, WNK1
 GO:0006468 2 / 258 48.3× 5.64e-4 1.03e-2 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Early-onset hypertension with severe exacerbation in pregnancy Pseudohyperaldosteronism type 2 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Early-onset hypertension with severe exacerbation in pregnancy Pseudohypoaldosteronism type i, autosomal dominant 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Early-onset hypertension with severe exacerbation in pregnancy Pseudohypoaldosteronism 1, autosomal dominant 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Pseudohyperaldosteronism type 2 Pseudohypoaldosteronism type i, autosomal dominant 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Pseudohyperaldosteronism type 2 Pseudohypoaldosteronism 1, autosomal dominant 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Pseudohypoaldosteronism 1, autosomal dominant Pseudohypoaldosteronism type i, autosomal dominant 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Early-onset hypertension with severe exacerbation in pregnancy Pseudohypoaldosteronism 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Pseudohyperaldosteronism type 2 Pseudohypoaldosteronism 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Pseudohypoaldosteronism Pseudohypoaldosteronism type i, autosomal dominant 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Pseudohypoaldosteronism Pseudohypoaldosteronism 1, autosomal dominant 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Pseudohypoaldosteronism Pseudohypoaldosteronism, type iib 0.250 1 1.94e-4 4.41e-4 ✓ sig.