Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 470

6 diseases · 8 shared-gene connections
6 Diseases
4 Unique genes
0.338 Avg. similarity score
Chronic mucocutaneous candidiasis Most-connected disease (5 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Chronic mucocutaneous candidiasis 5 5 3
Candidiasis, familial, 2 3 3 1
Deep dermatophytosis 3 3 1
Immunodeficiency 103, susceptibility to fungal infections 3 3 1
Candidiasis, familial, 9 1 1 1
Mendelian susceptibility to mycobacterial disease 1 1 2

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
CARD9 4 / 6 Candidiasis, familial, 2, Chronic mucocutaneous candidiasis, Deep dermatophytosis, Immunodeficiency 103, susceptibility to fungal infections
IL17RC 2 / 6 Candidiasis, familial, 9, Chronic mucocutaneous candidiasis
IL23R 2 / 6 Chronic mucocutaneous candidiasis, Mendelian susceptibility to mycobacterial disease
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Cytokine-cytokine receptor interaction
IL17RC, IL23R, IL12RB2
 KEGG 3 / 298 30.2× 5.94e-5 1.25e-3 ✓ sig.
Inflammatory bowel disease
IL23R, IL12RB2
 KEGG 2 / 66 91.0× 1.77e-4 2.98e-3 ✓ sig.
JAK-STAT signaling pathway
IL23R, IL12RB2
 KEGG 2 / 168 35.7× 1.15e-3 1.26e-2 ✓ sig.
Interleukin-17 signaling
IL17RC
 Reactome 1 / 8 375× 2.66e-3 2.34e-2 ✓ sig.
Interleukin-23 signaling
IL23R
 Reactome 1 / 9 334× 2.99e-3 2.54e-2 ✓ sig.
Interleukin-12 signaling
IL12RB2
 Reactome 1 / 10 300× 3.33e-3 2.74e-2 ✓ sig.
Interleukin-35 Signalling
IL12RB2
 Reactome 1 / 12 250× 3.99e-3 3.12e-2 ✓ sig.
Pathways in cancer
IL23R, IL12RB2
 KEGG 2 / 533 11.3× 1.11e-2 6.07e-2
CLEC7A (Dectin-1) signaling
CARD9
 Reactome 1 / 79 38.0× 2.61e-2 9.99e-2
Th1 and Th2 cell differentiation
IL12RB2
 KEGG 1 / 93 32.3× 3.06e-2 1.10e-1
IL-17 signaling pathway
IL17RC
 KEGG 1 / 94 31.9× 3.09e-2 1.10e-1
C-type lectin receptor signaling pathway
CARD9
 KEGG 1 / 105 28.6× 3.45e-2 1.17e-1
Interleukin-4 and Interleukin-13 signaling
IL23R
 Reactome 1 / 108 27.8× 3.55e-2 1.19e-1
Th17 cell differentiation
IL23R
 KEGG 1 / 109 27.5× 3.58e-2 1.19e-1
Alcoholic liver disease
IL17RC
 KEGG 1 / 144 20.9× 4.71e-2 1.40e-1

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
positive regulation of T-helper 17 type immune response
CARD9, IL23R
 GO:2000318 2 / 13 719× 2.68e-6 1.92e-4 ✓ sig.
positive regulation of granulocyte macrophage colony-stimulating factor production
CARD9, IL23R
 GO:0032725 2 / 15 623× 3.61e-6 2.43e-4 ✓ sig.
positive regulation of interleukin-17 production
CARD9, IL23R
 GO:0032740 2 / 27 346× 1.20e-5 6.28e-4 ✓ sig.
positive regulation of cytokine production involved in inflammatory response
CARD9, IL17RC
 GO:1900017 2 / 37 253× 2.28e-5 1.02e-3 ✓ sig.
positive regulation of type II interferon production
IL23R, IL12RB2
 GO:0032729 2 / 77 121× 1.00e-4 3.10e-3 ✓ sig.
positive regulation of interleukin-6 production
CARD9, IL17RC
 GO:0032755 2 / 103 90.7× 1.79e-4 4.70e-3 ✓ sig.
cytokine-mediated signaling pathway
IL23R, IL12RB2
 GO:0019221 2 / 145 64.4× 3.55e-4 7.57e-3 ✓ sig.
regulation of interleukin-2 production
CARD9
 GO:0032663 1 / 2 2,336× 4.28e-4 8.53e-3 ✓ sig.
response to lipopolysaccharide
IL23R, IL12RB2
 GO:0032496 2 / 161 58.0× 4.38e-4 8.68e-3 ✓ sig.
prolactin signaling pathway
IL23R
 GO:0038161 1 / 4 1,168× 8.56e-4 1.33e-2 ✓ sig.
granulocyte chemotaxis
IL17RC
 GO:0071621 1 / 5 934× 1.07e-3 1.51e-2 ✓ sig.
positive regulation of NK T cell activation
IL23R
 GO:0051135 1 / 5 934× 1.07e-3 1.51e-2 ✓ sig.
response to fungus
CARD9
 GO:0009620 1 / 6 779× 1.28e-3 1.67e-2 ✓ sig.
response to peptidoglycan
CARD9
 GO:0032494 1 / 6 779× 1.28e-3 1.67e-2 ✓ sig.
interleukin-23-mediated signaling pathway
IL23R
 GO:0038155 1 / 6 779× 1.28e-3 1.67e-2 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Candidiasis, familial, 2 Deep dermatophytosis 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Candidiasis, familial, 2 Immunodeficiency 103, susceptibility to fungal infections 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Deep dermatophytosis Immunodeficiency 103, susceptibility to fungal infections 0.500 1 6.46e-5 1.98e-4 ✓ sig.
Candidiasis, familial, 2 Chronic mucocutaneous candidiasis 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Candidiasis, familial, 9 Chronic mucocutaneous candidiasis 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Chronic mucocutaneous candidiasis Deep dermatophytosis 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Chronic mucocutaneous candidiasis Immunodeficiency 103, susceptibility to fungal infections 0.250 1 1.94e-4 4.41e-4 ✓ sig.
Chronic mucocutaneous candidiasis Mendelian susceptibility to mycobacterial disease 0.200 1 3.87e-4 7.33e-4 ✓ sig.