Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 275
7
Diseases
10
Unique genes
0.251
Avg. similarity score
Congenital diarrhea
Most-connected disease (5 links)
Disease
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Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details ·
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Congenital diarrhea
Chronic infantile diarrhea due to guanylate cyclase 2c overactivity
Congenital secretory diarrhea
Congenital sodium diarrhea
Duodenal atresia
Congenital chloride diarrhea
Congenital chronic diarrhea with protein-losing enteropathy
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Congenital diarrhea | 5 | 5 | 5 |
| Chronic infantile diarrhea due to guanylate cyclase 2c overactivity | 4 | 4 | 1 |
| Congenital secretory diarrhea | 4 | 4 | 4 |
| Congenital sodium diarrhea | 4 | 4 | 2 |
| Duodenal atresia | 4 | 4 | 1 |
| Congenital chloride diarrhea | 2 | 2 | 4 |
| Congenital chronic diarrhea with protein-losing enteropathy | 1 | 1 | 2 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| GUCY2C | 5 / 7 | Chronic infantile diarrhea due to guanylate cyclase 2c overactivity, Congenital diarrhea, Congenital secretory diarrhea, Congenital sodium diarrhea and 1 more |
| DGAT1 | 2 / 7 | Congenital chronic diarrhea with protein-losing enteropathy, Congenital diarrhea |
| GRWD1 | 2 / 7 | Congenital chloride diarrhea, Congenital diarrhea |
| PLVAP | 2 / 7 | Congenital chronic diarrhea with protein-losing enteropathy, Congenital diarrhea |
| SLC26A3 | 2 / 7 | Congenital chloride diarrhea, Congenital secretory diarrhea |
| SLC9A3 | 2 / 7 | Congenital secretory diarrhea, Congenital sodium diarrhea |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) | Reactome | 1 / 1 | 1,201× | 8.33e-4 | 1.18e-2 ✓ sig. |
| Mineral absorption | KEGG | 2 / 61 | 39.4× | 1.11e-3 | 1.47e-2 ✓ sig. |
| Intestinal infectious diseases | Reactome | 1 / 2 | 601× | 1.66e-3 | 2.00e-2 ✓ sig. |
| Signaling by MST1 | Reactome | 1 / 5 | 240× | 4.16e-3 | 3.87e-2 ✓ sig. |
| Digestion | Reactome | 1 / 5 | 240× | 4.16e-3 | 3.87e-2 ✓ sig. |
| MET Receptor Activation | Reactome | 1 / 6 | 200× | 4.99e-3 | 4.37e-2 ✓ sig. |
| Acyl chain remodeling of DAG and TAG | Reactome | 1 / 7 | 172× | 5.82e-3 | 4.84e-2 ✓ sig. |
| Sodium/Proton exchangers | Reactome | 1 / 9 | 133× | 7.47e-3 | 5.69e-2 |
| Multifunctional anion exchangers | Reactome | 1 / 9 | 133× | 7.47e-3 | 5.69e-2 |
| Triglyceride biosynthesis | Reactome | 1 / 13 | 92.4× | 1.08e-2 | 7.19e-2 |
| Proximal tubule bicarbonate reclamation | KEGG | 1 / 23 | 52.2× | 1.90e-2 | 9.98e-2 |
| Fat digestion and absorption | KEGG | 1 / 43 | 27.9× | 3.52e-2 | 1.41e-1 |
| Virion - Hepatitis viruses | KEGG | 1 / 48 | 25.0× | 3.93e-2 | 1.50e-1 |
| Glycerolipid metabolism | KEGG | 1 / 64 | 18.8× | 5.20e-2 | 1.75e-1 |
| Retinol metabolism | KEGG | 1 / 68 | 17.7× | 5.52e-2 | 1.80e-1 |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| vesicle localization | GO:0051648 | 1 / 2 | 934× | 1.07e-3 | 1.57e-2 ✓ sig. |
| intracellular pH elevation | GO:0051454 | 1 / 3 | 623× | 1.60e-3 | 1.98e-2 ✓ sig. |
| epithelial cell morphogenesis involved in placental branching | GO:0060672 | 1 / 3 | 623× | 1.60e-3 | 1.98e-2 ✓ sig. |
| positive regulation of cellular extravasation | GO:0002693 | 1 / 5 | 374× | 2.67e-3 | 2.65e-2 ✓ sig. |
| long-chain fatty-acyl-CoA metabolic process | GO:0035336 | 1 / 7 | 267× | 3.74e-3 | 3.18e-2 ✓ sig. |
| microvillus assembly | GO:0030033 | 1 / 8 | 234× | 4.27e-3 | 3.38e-2 ✓ sig. |
| membrane hyperpolarization | GO:0060081 | 1 / 8 | 234× | 4.27e-3 | 3.38e-2 ✓ sig. |
| monoacylglycerol biosynthetic process | GO:0006640 | 1 / 9 | 208× | 4.81e-3 | 3.58e-2 ✓ sig. |
| negative regulation of cell-cell adhesion mediated by cadherin | GO:2000048 | 1 / 11 | 170× | 5.87e-3 | 3.98e-2 ✓ sig. |
| receptor guanylyl cyclase signaling pathway | GO:0007168 | 1 / 11 | 170× | 5.87e-3 | 3.98e-2 ✓ sig. |
| oxalate transport | GO:0019532 | 1 / 11 | 170× | 5.87e-3 | 3.98e-2 ✓ sig. |
| very-low-density lipoprotein particle assembly | GO:0034379 | 1 / 12 | 156× | 6.40e-3 | 4.15e-2 ✓ sig. |
| negative regulation of neural precursor cell proliferation | GO:2000178 | 1 / 12 | 156× | 6.40e-3 | 4.15e-2 ✓ sig. |
| cGMP biosynthetic process | GO:0006182 | 1 / 13 | 144× | 6.94e-3 | 4.33e-2 ✓ sig. |
| negative regulation of cell motility | GO:2000146 | 1 / 14 | 133× | 7.47e-3 | 4.46e-2 ✓ sig. |