Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 177

9 diseases · 26 shared-gene connections
9 Diseases
2 Unique genes
0.462 Avg. similarity score
Corticosterone methyl oxidase type i Most-connected disease (7 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Corticosterone methyl oxidase type i 7 7 1
Corticosterone methyloxidase deficiency 7 7 1
Corticosterone monooxygenase deficiency 7 7 1
Familial hypoaldosteronism 7 7 1
Hyperreninemic hypoaldosteronism 7 7 1
Glucocorticoid-remediable aldosteronism 6 6 2
Hypoaldosteronism 5 5 1
familial hyperreninemic hypoaldosteronism type 2 5 5 1
Steroid 11-beta-monooxygenase deficiency 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
CYP11B2 8 / 9 Corticosterone methyl oxidase type i, Corticosterone methyloxidase deficiency, Corticosterone monooxygenase deficiency, familial hyperreninemic hypoaldosteronism type 2 and 4 more
CYP11B1 2 / 9 Glucocorticoid-remediable aldosteronism, Steroid 11-beta-monooxygenase deficiency
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Glucocorticoid biosynthesis
CYP11B2, CYP11B1
 Reactome 2 / 10 1,201× 6.24e-7 3.23e-5 ✓ sig.
Endogenous sterols
CYP11B2, CYP11B1
 Reactome 2 / 25 480× 4.16e-6 1.63e-4 ✓ sig.
Steroid hormone biosynthesis
CYP11B2, CYP11B1
 KEGG 2 / 63 191× 2.71e-5 7.65e-4 ✓ sig.
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
CYP11B1
 Reactome 1 / 1 6,005× 1.67e-4 3.38e-3 ✓ sig.
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
CYP11B2
 Reactome 1 / 1 6,005× 1.67e-4 3.38e-3 ✓ sig.
Mineralocorticoid biosynthesis
CYP11B2
 Reactome 1 / 6 1,001× 9.99e-4 1.35e-2 ✓ sig.
Cortisol synthesis and secretion
CYP11B1
 KEGG 1 / 65 92.4× 1.08e-2 7.19e-2
Aldosterone synthesis and secretion
CYP11B2
 KEGG 1 / 98 61.3× 1.63e-2 9.14e-2
Metabolic pathways
CYP11B2, CYP11B1
 KEGG 2 / 1,563 7.7× 1.69e-2 9.38e-2
Cushing syndrome
CYP11B1
 KEGG 1 / 155 38.7× 2.56e-2 1.18e-1

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
aldosterone biosynthetic process
CYP11B2, CYP11B1
 GO:0032342 2 / 3 6,229× 1.72e-8 2.73e-6 ✓ sig.
cortisol metabolic process
CYP11B2, CYP11B1
 GO:0034650 2 / 4 4,672× 3.44e-8 4.93e-6 ✓ sig.
cortisol biosynthetic process
CYP11B2, CYP11B1
 GO:0034651 2 / 5 3,737× 5.73e-8 7.60e-6 ✓ sig.
C21-steroid hormone biosynthetic process
CYP11B2, CYP11B1
 GO:0006700 2 / 5 3,737× 5.73e-8 7.60e-6 ✓ sig.
glucocorticoid biosynthetic process
CYP11B2, CYP11B1
 GO:0006704 2 / 7 2,670× 1.20e-7 1.41e-5 ✓ sig.
cellular response to potassium ion
CYP11B2, CYP11B1
 GO:0035865 2 / 14 1,335× 5.21e-7 4.84e-5 ✓ sig.
alcohol metabolic process
CYP11B2, CYP11B1
 GO:0006066 2 / 18 1,038× 8.76e-7 7.44e-5 ✓ sig.
cellular response to peptide hormone stimulus
CYP11B2, CYP11B1
 GO:0071375 2 / 18 1,038× 8.76e-7 7.44e-5 ✓ sig.
sterol metabolic process
CYP11B2, CYP11B1
 GO:0016125 2 / 22 849× 1.32e-6 1.03e-4 ✓ sig.
cellular response to hormone stimulus
CYP11B2, CYP11B1
 GO:0032870 2 / 48 389× 6.46e-6 3.68e-4 ✓ sig.
steroid biosynthetic process
CYP11B2, CYP11B1
 GO:0006694 2 / 65 287× 1.19e-5 5.97e-4 ✓ sig.
cholesterol metabolic process
CYP11B2, CYP11B1
 GO:0008203 2 / 107 175× 3.25e-5 1.30e-3 ✓ sig.
regulation of blood volume by renal aldosterone
CYP11B2
 GO:0002017 1 / 2 4,672× 2.14e-4 5.28e-3 ✓ sig.
mineralocorticoid biosynthetic process
CYP11B2
 GO:0006705 1 / 2 4,672× 2.14e-4 5.28e-3 ✓ sig.
lipid metabolic process
CYP11B2, CYP11B1
 GO:0006629 2 / 840 22.2× 2.02e-3 2.27e-2 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Corticosterone methyl oxidase type i Corticosterone methyloxidase deficiency 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hyperreninemic hypoaldosteronism Hypoaldosteronism 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Familial hypoaldosteronism Hypoaldosteronism 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Familial hypoaldosteronism Hyperreninemic hypoaldosteronism 0.500 1 6.49e-5 2.34e-4 ✓ sig.
familial hyperreninemic hypoaldosteronism type 2 Hyperreninemic hypoaldosteronism 0.500 1 6.49e-5 2.34e-4 ✓ sig.
familial hyperreninemic hypoaldosteronism type 2 Familial hypoaldosteronism 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Corticosterone methyloxidase deficiency familial hyperreninemic hypoaldosteronism type 2 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Corticosterone monooxygenase deficiency familial hyperreninemic hypoaldosteronism type 2 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Corticosterone methyl oxidase type i familial hyperreninemic hypoaldosteronism type 2 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Corticosterone monooxygenase deficiency Hypoaldosteronism 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Corticosterone monooxygenase deficiency Hyperreninemic hypoaldosteronism 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Corticosterone monooxygenase deficiency Familial hypoaldosteronism 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Corticosterone methyloxidase deficiency Hypoaldosteronism 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Corticosterone methyloxidase deficiency Hyperreninemic hypoaldosteronism 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Corticosterone methyloxidase deficiency Familial hypoaldosteronism 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Corticosterone methyloxidase deficiency Corticosterone monooxygenase deficiency 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Corticosterone methyl oxidase type i Hypoaldosteronism 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Corticosterone methyl oxidase type i Hyperreninemic hypoaldosteronism 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Corticosterone methyl oxidase type i Familial hypoaldosteronism 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Corticosterone methyl oxidase type i Corticosterone monooxygenase deficiency 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Corticosterone methyl oxidase type i Glucocorticoid-remediable aldosteronism 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Corticosterone monooxygenase deficiency Glucocorticoid-remediable aldosteronism 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Corticosterone methyloxidase deficiency Glucocorticoid-remediable aldosteronism 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Familial hypoaldosteronism Glucocorticoid-remediable aldosteronism 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Glucocorticoid-remediable aldosteronism Hyperreninemic hypoaldosteronism 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Glucocorticoid-remediable aldosteronism Steroid 11-beta-monooxygenase deficiency 0.333 1 1.30e-4 3.90e-4 ✓ sig.