Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
← Back to all clusters
Cluster 132
10
Diseases
11
Unique genes
0.396
Avg. similarity score
Anemia, x-linked
Most-connected disease (7 links)
Disease
Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details ·
click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) ·
drag a node to pin it in place · scroll/pinch to zoom.
Anemia, x-linked
Congenital erythropoietic porphyria
Dyserythropoietic anemia with abnormal platelets and neutropenia
Dyserythropoietic anemia with thrombocytopenia
Thrombocytopenia with dyserythropoietic anemia
Cutaneous porphyria
GATA1-Related X-Linked Cytopenia
Transient myeloproliferative disorder
Porphyria
hereditary thrombocytopenia and hematologic cancer predisposition syndrome
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Anemia, x-linked | 7 | 7 | 1 |
| Congenital erythropoietic porphyria | 7 | 7 | 2 |
| Dyserythropoietic anemia with abnormal platelets and neutropenia | 7 | 7 | 1 |
| Dyserythropoietic anemia with thrombocytopenia | 7 | 7 | 1 |
| Thrombocytopenia with dyserythropoietic anemia | 7 | 7 | 1 |
| Cutaneous porphyria | 6 | 6 | 2 |
| GATA1-Related X-Linked Cytopenia | 5 | 5 | 1 |
| Transient myeloproliferative disorder | 5 | 5 | 2 |
| Porphyria | 2 | 2 | 10 |
| hereditary thrombocytopenia and hematologic cancer predisposition syndrome | 1 | 1 | 1 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| GATA1 | 9 / 10 | Anemia, x-linked, Congenital erythropoietic porphyria, Cutaneous porphyria, Dyserythropoietic anemia with abnormal platelets and neutropenia and 5 more |
| UROS | 3 / 10 | Congenital erythropoietic porphyria, Cutaneous porphyria, Porphyria |
| RUNX1 | 2 / 10 | hereditary thrombocytopenia and hematologic cancer predisposition syndrome, Transient myeloproliferative disorder |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| heme B biosynthetic process | GO:0006785 | 8 / 10 | 1,359× | 2.02e-26 | 7.27e-23 ✓ sig. |
| protoporphyrinogen IX biosynthetic process | GO:0006782 | 7 / 9 | 1,321× | 7.53e-23 | 1.80e-19 ✓ sig. |
| heme O biosynthetic process | GO:0048034 | 7 / 9 | 1,321× | 7.53e-23 | 1.80e-19 ✓ sig. |
| heme A biosynthetic process | GO:0006784 | 7 / 10 | 1,189× | 2.51e-22 | 5.59e-19 ✓ sig. |
| heme biosynthetic process | GO:0006783 | 8 / 27 | 503× | 9.92e-22 | 1.99e-18 ✓ sig. |
| porphyrin-containing compound biosynthetic process | GO:0006779 | 6 / 11 | 927× | 3.61e-18 | 4.41e-15 ✓ sig. |
| tetrapyrrole biosynthetic process | GO:0033014 | 5 / 5 | 1,699× | 2.43e-17 | 2.66e-14 ✓ sig. |
| response to platinum ion | GO:0070541 | 4 / 4 | 1,699× | 6.50e-14 | 3.68e-11 ✓ sig. |
| hemoglobin biosynthetic process | GO:0042541 | 3 / 6 | 849× | 3.03e-9 | 5.96e-7 ✓ sig. |
| porphyrin-containing compound metabolic process | GO:0006778 | 3 / 7 | 728× | 5.30e-9 | 9.83e-7 ✓ sig. |
| erythrocyte differentiation | GO:0030218 | 4 / 65 | 105× | 4.32e-8 | 5.98e-6 ✓ sig. |
| erythrocyte development | GO:0048821 | 3 / 32 | 159× | 7.46e-7 | 6.54e-5 ✓ sig. |
| protoporphyrinogen IX metabolic process | GO:0046501 | 2 / 3 | 1,133× | 9.45e-7 | 7.93e-5 ✓ sig. |
| response to hypoxia | GO:0001666 | 4 / 176 | 38.6× | 2.38e-6 | 1.66e-4 ✓ sig. |
| response to herbicide | GO:0009635 | 2 / 5 | 680× | 3.15e-6 | 2.07e-4 ✓ sig. |