ZZZ3 (zinc finger ZZ-type containing 3)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 26009 |
| Gene name | Zinc finger ZZ-type containing 3 |
| Gene symbol | ZZZ3 |
| Synonyms (NCBI Gene) |
ATAC1
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| Chromosome | 1 |
| Chromosome location | 1p31.1 |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q8IYH5 | |||||||||||||||
| Protein name | ZZ-type zinc finger-containing protein 3 | |||||||||||||||
| Protein function | Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed:30217978). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (Pu | |||||||||||||||
| PDB | 2FC7 , 2YUM , 6E83 , 6E86 | |||||||||||||||
| Family and domains |
Pfam
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| Sequence |
MAASRSTRVTRSTVGLNGLDESFCGRTLRNRSIAHPEEISSNSQVRSRSPKKRPEPVPIQ |
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| Sequence length | 903 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with ZZZ3 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to ZZZ3 (see Related Genes above), that are NOT already directly curated for ZZZ3 itself -- a lead worth checking, not a confirmed association.
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