ZSCAN23 (zinc finger and SCAN domain containing 23)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 222696
• Gene name: Zinc finger and SCAN domain containing 23
• Gene symbol: ZSCAN23
• Synonyms (NCBI Gene): ZNF390, ZNF453, dJ29K1.3, dJ29K1.3.1
• Chromosome: 6
• Chromosome location: 6p22.1

miRNA Show/Hide all (136)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017469	hsa-miR-335-5p	Microarray	18185580
MIRT639632	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT639631	hsa-miR-3682-5p	HITS-CLIP	23824327
MIRT639630	hsa-miR-7977	HITS-CLIP	23824327
MIRT639629	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639628	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT639627	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT639626	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT639633	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT639634	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT639632	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT639631	hsa-miR-3682-5p	HITS-CLIP	23824327
MIRT639630	hsa-miR-7977	HITS-CLIP	23824327
MIRT639629	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639628	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT639627	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT639626	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT639632	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT639631	hsa-miR-3682-5p	HITS-CLIP	23824327
MIRT639630	hsa-miR-7977	HITS-CLIP	23824327
MIRT639629	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639628	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT639627	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT639626	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT639633	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT639634	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT639632	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT639631	hsa-miR-3682-5p	HITS-CLIP	23824327
MIRT639630	hsa-miR-7977	HITS-CLIP	23824327
MIRT639629	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639628	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT639627	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT639626	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT1543711	hsa-miR-1236	CLIP-seq
MIRT1543712	hsa-miR-135a	CLIP-seq
MIRT1543713	hsa-miR-135b	CLIP-seq
MIRT1543714	hsa-miR-3150b-3p	CLIP-seq
MIRT1543715	hsa-miR-3977	CLIP-seq
MIRT1543716	hsa-miR-4252	CLIP-seq
MIRT1543717	hsa-miR-4277	CLIP-seq
MIRT1543718	hsa-miR-4635	CLIP-seq
MIRT1543719	hsa-miR-4689	CLIP-seq
MIRT1543720	hsa-miR-4784	CLIP-seq
MIRT1543721	hsa-miR-4803	CLIP-seq
MIRT1543722	hsa-miR-502-5p	CLIP-seq
MIRT1543723	hsa-miR-513a-3p	CLIP-seq
MIRT1543724	hsa-miR-548c-3p	CLIP-seq
MIRT1543725	hsa-miR-590-3p	CLIP-seq
MIRT1543726	hsa-miR-604	CLIP-seq
MIRT1543727	hsa-miR-647	CLIP-seq
MIRT1543728	hsa-miR-942	CLIP-seq
MIRT1555876	hsa-miR-146a	CLIP-seq
MIRT1555877	hsa-miR-146b-5p	CLIP-seq
MIRT1555878	hsa-miR-3171	CLIP-seq
MIRT1555879	hsa-miR-383	CLIP-seq
MIRT1555880	hsa-miR-3919	CLIP-seq
MIRT1555881	hsa-miR-3925-5p	CLIP-seq
MIRT1555882	hsa-miR-4756-3p	CLIP-seq
MIRT1555883	hsa-miR-4772-5p	CLIP-seq
MIRT2164067	hsa-miR-1197	CLIP-seq
MIRT2164068	hsa-miR-154	CLIP-seq
MIRT2164069	hsa-miR-214	CLIP-seq
MIRT2164070	hsa-miR-3125	CLIP-seq
MIRT2164071	hsa-miR-3607-3p	CLIP-seq
MIRT2164072	hsa-miR-3619-5p	CLIP-seq
MIRT2164073	hsa-miR-3690	CLIP-seq
MIRT2164074	hsa-miR-378	CLIP-seq
MIRT2164075	hsa-miR-378b	CLIP-seq
MIRT2164076	hsa-miR-378c	CLIP-seq
MIRT2164077	hsa-miR-378d	CLIP-seq
MIRT2164078	hsa-miR-378e	CLIP-seq
MIRT2164079	hsa-miR-378f	CLIP-seq
MIRT2164080	hsa-miR-378h	CLIP-seq
MIRT2164081	hsa-miR-378i	CLIP-seq
MIRT2164082	hsa-miR-3916	CLIP-seq
MIRT2164083	hsa-miR-3973	CLIP-seq
MIRT2164084	hsa-miR-422a	CLIP-seq
MIRT2164085	hsa-miR-4254	CLIP-seq
MIRT2164086	hsa-miR-520d-5p	CLIP-seq
MIRT2164087	hsa-miR-524-5p	CLIP-seq
MIRT2164088	hsa-miR-548a-5p	CLIP-seq
MIRT2164089	hsa-miR-548ab	CLIP-seq
MIRT2164090	hsa-miR-548ak	CLIP-seq
MIRT2164091	hsa-miR-548b-5p	CLIP-seq
MIRT2164092	hsa-miR-548c-5p	CLIP-seq
MIRT2164093	hsa-miR-548d-5p	CLIP-seq
MIRT2164094	hsa-miR-548h	CLIP-seq
MIRT2164095	hsa-miR-548i	CLIP-seq
MIRT2164096	hsa-miR-548j	CLIP-seq
MIRT2164097	hsa-miR-548w	CLIP-seq
MIRT2164098	hsa-miR-548y	CLIP-seq
MIRT2164099	hsa-miR-559	CLIP-seq
MIRT2164100	hsa-miR-761	CLIP-seq
MIRT2164101	hsa-miR-877	CLIP-seq
MIRT2164067	hsa-miR-1197	CLIP-seq
MIRT2164069	hsa-miR-214	CLIP-seq
MIRT2164070	hsa-miR-3125	CLIP-seq
MIRT2164072	hsa-miR-3619-5p	CLIP-seq
MIRT2164082	hsa-miR-3916	CLIP-seq
MIRT2164083	hsa-miR-3973	CLIP-seq
MIRT2164088	hsa-miR-548a-5p	CLIP-seq
MIRT2164089	hsa-miR-548ab	CLIP-seq
MIRT2164090	hsa-miR-548ak	CLIP-seq
MIRT2164091	hsa-miR-548b-5p	CLIP-seq
MIRT2164092	hsa-miR-548c-5p	CLIP-seq
MIRT2164093	hsa-miR-548d-5p	CLIP-seq
MIRT2164094	hsa-miR-548h	CLIP-seq
MIRT2164095	hsa-miR-548i	CLIP-seq
MIRT2164096	hsa-miR-548j	CLIP-seq
MIRT2164097	hsa-miR-548w	CLIP-seq
MIRT2164098	hsa-miR-548y	CLIP-seq
MIRT2164099	hsa-miR-559	CLIP-seq
MIRT2164100	hsa-miR-761	CLIP-seq
MIRT2164101	hsa-miR-877	CLIP-seq
MIRT2164067	hsa-miR-1197	CLIP-seq
MIRT2164069	hsa-miR-214	CLIP-seq
MIRT2164070	hsa-miR-3125	CLIP-seq
MIRT2164072	hsa-miR-3619-5p	CLIP-seq
MIRT2164082	hsa-miR-3916	CLIP-seq
MIRT2164083	hsa-miR-3973	CLIP-seq
MIRT2164088	hsa-miR-548a-5p	CLIP-seq
MIRT2164089	hsa-miR-548ab	CLIP-seq
MIRT2164090	hsa-miR-548ak	CLIP-seq
MIRT2164091	hsa-miR-548b-5p	CLIP-seq
MIRT2164092	hsa-miR-548c-5p	CLIP-seq
MIRT2164093	hsa-miR-548d-5p	CLIP-seq
MIRT2164094	hsa-miR-548h	CLIP-seq
MIRT2164095	hsa-miR-548i	CLIP-seq
MIRT2164096	hsa-miR-548j	CLIP-seq
MIRT2164097	hsa-miR-548w	CLIP-seq
MIRT2164098	hsa-miR-548y	CLIP-seq
MIRT2164099	hsa-miR-559	CLIP-seq
MIRT2164100	hsa-miR-761	CLIP-seq
MIRT2164101	hsa-miR-877	CLIP-seq
MIRT2696441	hsa-miR-4475	CLIP-seq
MIRT1543723	hsa-miR-513a-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q3MJ62
• Protein name: Zinc finger and SCAN domain-containing protein 23 (Zinc finger protein 390) (Zinc finger protein 453)
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	333 → 355	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	277 → 299	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	305 → 327	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	249 → 271	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	361 → 383	Zinc finger, C2H2 type	Domain
  PF02023	SCAN	44 → 133	SCAN domain	Domain

• Sequence:

  MAITLTLQTAEMQEGLLAVKVKEEEEEHSCGPESGLSRNNPHTREIFRRRFRQFCYQESP
  GPREALQRLQELCHQWLRPEMHTKEQILELLVLEQFLTILPEELQAWVRQHRPVSGEEAV
  TVLEDLERELDDPGEQVLSHAHEQEEFVKEKATPGAAQESSNDQFQTLEEQLGYNLREVC
  PVQEIDGKAGTWNVELAPKREISQEVKSLIQVLGKQNGNITQIPEYGDTCDREGRLEKQR
  VSSSVERPYICSECGKSFTQNSILIEHQRTHTGEKPYECDECGRAFSQRSGLFQHQRLHT
  GEKRYQCSVCGKAFSQNAGLFHHLRIHTGEKPYQCNQCNKSFSRRSVLIKHQRIHTGERP
  YECEECGKNFIYHCNLIQHRKVHPVAESS

• Sequence length: 389

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (11)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	38102678	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	28604730	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CANCER	—	GWAS catalog	28604730	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	28604730	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	34634379	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	37377963	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	39885523	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	36762574, 37377963	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	31268507	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	28604730	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	33272962	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Schizophrenia	Schizophrenia	GWASCAT_DG	31268507		★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

No strongly related genes found yet for ZSCAN23.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZSCAN23.