ZSCAN1 (zinc finger and SCAN domain containing 1)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 284312
• Gene name: Zinc finger and SCAN domain containing 1
• Gene symbol: ZSCAN1
• Synonyms (NCBI Gene): MZF-1, ZNF915
• Chromosome: 19
• Chromosome location: 19q13.43

miRNA Show/Hide all (45)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1543539	hsa-miR-1206	CLIP-seq
MIRT1543540	hsa-miR-1275	CLIP-seq
MIRT1543541	hsa-miR-2964a-5p	CLIP-seq
MIRT1543542	hsa-miR-3151	CLIP-seq
MIRT1543543	hsa-miR-3545-3p	CLIP-seq
MIRT1543544	hsa-miR-361-3p	CLIP-seq
MIRT1543545	hsa-miR-4252	CLIP-seq
MIRT1543546	hsa-miR-4283	CLIP-seq
MIRT1543547	hsa-miR-4489	CLIP-seq
MIRT1543548	hsa-miR-4492	CLIP-seq
MIRT1543549	hsa-miR-4498	CLIP-seq
MIRT1543550	hsa-miR-4505	CLIP-seq
MIRT1543551	hsa-miR-4525	CLIP-seq
MIRT1543552	hsa-miR-4539	CLIP-seq
MIRT1543553	hsa-miR-4665-5p	CLIP-seq
MIRT1543554	hsa-miR-4723-5p	CLIP-seq
MIRT1543555	hsa-miR-4724-5p	CLIP-seq
MIRT1543556	hsa-miR-4731-5p	CLIP-seq
MIRT1543557	hsa-miR-579	CLIP-seq
MIRT1543558	hsa-miR-625	CLIP-seq
MIRT1543559	hsa-miR-637	CLIP-seq
MIRT1543560	hsa-miR-762	CLIP-seq
MIRT2464763	hsa-miR-3661	CLIP-seq
MIRT2464764	hsa-miR-3690	CLIP-seq
MIRT2464765	hsa-miR-4270	CLIP-seq
MIRT2464766	hsa-miR-4441	CLIP-seq
MIRT2464767	hsa-miR-4638-3p	CLIP-seq
MIRT2464768	hsa-miR-619	CLIP-seq
MIRT2464769	hsa-miR-631	CLIP-seq
MIRT2464770	hsa-miR-769-5p	CLIP-seq
MIRT2464763	hsa-miR-3661	CLIP-seq
MIRT2464764	hsa-miR-3690	CLIP-seq
MIRT2464765	hsa-miR-4270	CLIP-seq
MIRT2464766	hsa-miR-4441	CLIP-seq
MIRT2464767	hsa-miR-4638-3p	CLIP-seq
MIRT2464768	hsa-miR-619	CLIP-seq
MIRT2464769	hsa-miR-631	CLIP-seq
MIRT2464770	hsa-miR-769-5p	CLIP-seq
MIRT2464763	hsa-miR-3661	CLIP-seq
MIRT2464764	hsa-miR-3690	CLIP-seq
MIRT2464767	hsa-miR-4638-3p	CLIP-seq
MIRT2696431	hsa-miR-4766-5p	CLIP-seq
MIRT2464768	hsa-miR-619	CLIP-seq
MIRT2464769	hsa-miR-631	CLIP-seq
MIRT2464770	hsa-miR-769-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 620026
• HGNC: 23712
• e!Ensembl: ENSG00000152467

Protein

• UniProt ID: Q8NBB4
• Protein name: Zinc finger and SCAN domain-containing protein 1
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02023	SCAN	34 → 123	SCAN domain	Domain

• Sequence:

  MLPRPKAPASPRRPQTPTPSEQDADPGPASPRDTEAQRLRFRQFQYHVASGPHLALGQLW
  TLCRQWLRPEARSKEQMLELLVLEQFLGALPSKMRTWVQSQGPRSCREAASLVEDLTQMC
  QQEVLVSLDSVEPQDWSFGEEEDGKSPRSQKEPSQASELILDAVAAAPALPEESEWLETT
  QLQQSLHTRAEAEAPRAPGLLGSRARLPLKPSIWDEPEDLLAGPSSDLRAEGTVISSPKG
  PSAQRISPRRRNRNTDQSGRHQPSLKHTKGGTQEAVAGISVVPRGPRGGRPFQCADCGMV
  FTWVTHFIEHQKTHREEGPFPCPECGKVFLHNSVLTEHGKIHLLEPPRKKAPRSKGPRES
  VPPRDGAQGPVAPRSPKRPFQCSVCGKAFPWMVHLIDHQKLHTAHGHM

• Sequence length: 408

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Colon adenocarcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (8)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
cervical cancer	Cervical Cancer	BEFREE	22846578		★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	22846578		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	26010542		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	17999073		★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	22846578		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	25451081		★☆☆☆☆ Found in Text Mining only
Transitional cell carcinoma of bladder	Bladder carcinoma	BEFREE	22559731		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	27542222		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for ZSCAN1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZSCAN1.