ZNG1B (Zn regulated GTPase metalloprotein activator 1B)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 150472
• Gene name: Zn regulated GTPase metalloprotein activator 1B
• Gene symbol: ZNG1B
• Synonyms (NCBI Gene): CBWD2
• Chromosome: 2
• Chromosome location: 2q14.1

miRNA Show/Hide all (71)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019933	hsa-miR-375	Microarray	20215506
MIRT2385591	hsa-miR-132	CLIP-seq
MIRT2385592	hsa-miR-212	CLIP-seq
MIRT2497462	hsa-miR-1207-3p	CLIP-seq
MIRT2497463	hsa-miR-2113	CLIP-seq
MIRT2497464	hsa-miR-2276	CLIP-seq
MIRT2497465	hsa-miR-30a	CLIP-seq
MIRT2497466	hsa-miR-30b	CLIP-seq
MIRT2497467	hsa-miR-30c	CLIP-seq
MIRT2497468	hsa-miR-30d	CLIP-seq
MIRT2497469	hsa-miR-30e	CLIP-seq
MIRT2497470	hsa-miR-3117-5p	CLIP-seq
MIRT2497471	hsa-miR-3145-5p	CLIP-seq
MIRT2497472	hsa-miR-3152-3p	CLIP-seq
MIRT2497473	hsa-miR-3168	CLIP-seq
MIRT2497474	hsa-miR-340	CLIP-seq
MIRT2497475	hsa-miR-3611	CLIP-seq
MIRT2497476	hsa-miR-3617	CLIP-seq
MIRT2497477	hsa-miR-3662	CLIP-seq
MIRT2497478	hsa-miR-3675-3p	CLIP-seq
MIRT2497479	hsa-miR-380	CLIP-seq
MIRT2497480	hsa-miR-382	CLIP-seq
MIRT2497481	hsa-miR-409-3p	CLIP-seq
MIRT2497482	hsa-miR-410	CLIP-seq
MIRT2497483	hsa-miR-4263	CLIP-seq
MIRT2497484	hsa-miR-4282	CLIP-seq
MIRT2497485	hsa-miR-4495	CLIP-seq
MIRT2497486	hsa-miR-4528	CLIP-seq
MIRT2497487	hsa-miR-4670-3p	CLIP-seq
MIRT2497488	hsa-miR-4772-3p	CLIP-seq
MIRT2497489	hsa-miR-4795-3p	CLIP-seq
MIRT2497490	hsa-miR-488	CLIP-seq
MIRT2497491	hsa-miR-581	CLIP-seq
MIRT2497492	hsa-miR-607	CLIP-seq
MIRT2497493	hsa-miR-641	CLIP-seq
MIRT2497494	hsa-miR-653	CLIP-seq
MIRT2497495	hsa-miR-656	CLIP-seq
MIRT2497496	hsa-miR-758	CLIP-seq
MIRT2497462	hsa-miR-1207-3p	CLIP-seq
MIRT2497463	hsa-miR-2113	CLIP-seq
MIRT2497464	hsa-miR-2276	CLIP-seq
MIRT2497465	hsa-miR-30a	CLIP-seq
MIRT2497466	hsa-miR-30b	CLIP-seq
MIRT2497467	hsa-miR-30c	CLIP-seq
MIRT2497468	hsa-miR-30d	CLIP-seq
MIRT2497469	hsa-miR-30e	CLIP-seq
MIRT2497470	hsa-miR-3117-5p	CLIP-seq
MIRT2497471	hsa-miR-3145-5p	CLIP-seq
MIRT2497472	hsa-miR-3152-3p	CLIP-seq
MIRT2497473	hsa-miR-3168	CLIP-seq
MIRT2497474	hsa-miR-340	CLIP-seq
MIRT2497475	hsa-miR-3611	CLIP-seq
MIRT2497476	hsa-miR-3617	CLIP-seq
MIRT2497477	hsa-miR-3662	CLIP-seq
MIRT2497478	hsa-miR-3675-3p	CLIP-seq
MIRT2497479	hsa-miR-380	CLIP-seq
MIRT2497480	hsa-miR-382	CLIP-seq
MIRT2497481	hsa-miR-409-3p	CLIP-seq
MIRT2497483	hsa-miR-4263	CLIP-seq
MIRT2497484	hsa-miR-4282	CLIP-seq
MIRT2497485	hsa-miR-4495	CLIP-seq
MIRT2497486	hsa-miR-4528	CLIP-seq
MIRT2497487	hsa-miR-4670-3p	CLIP-seq
MIRT2497488	hsa-miR-4772-3p	CLIP-seq
MIRT2497489	hsa-miR-4795-3p	CLIP-seq
MIRT2497490	hsa-miR-488	CLIP-seq
MIRT2497491	hsa-miR-581	CLIP-seq
MIRT2497492	hsa-miR-607	CLIP-seq
MIRT2497493	hsa-miR-641	CLIP-seq
MIRT2497494	hsa-miR-653	CLIP-seq
MIRT2497496	hsa-miR-758	CLIP-seq

Gene ontology (GO) Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005525	Function	GTP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 611079
• HGNC: 17907
• e!Ensembl: ENSG00000136682

Protein

• UniProt ID: Q8IUF1
• Protein name: Zinc-regulated GTPase metalloprotein activator 1B (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 2) (COBW domain-containing protein 2)
• Protein function: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from po
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02492	cobW	43 → 231	CobW/HypB/UreG, nucleotide-binding domain	Domain
  PF07683	CobW_C	274 → 377	Cobalamin synthesis protein cobW C-terminal domain	Domain

• Sequence:

  MLPAVGSADEEEDPAEEDCPELVPMETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLN
  YILTEQHSKRVAVILNEFGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLRAI
  ENLMQKKGKFDYILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLAE
  EKPDGLINEATRQVALADAILINKTDLVPEEDVKKLRATIRSINGLGQILETQRSRVDLS
  NVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWE
  KNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLL
  GRNLDKDILKQLFIATVTETEKQWTTHFKEDQVCT

• Sequence length: 395

Related Genes

No strongly related genes found yet for ZNG1B.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZNG1B.