ZNF808 (zinc finger protein 808)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 388558
• Gene name: Zinc finger protein 808
• Gene symbol: ZNF808
• Synonyms (NCBI Gene): PAGEN3
• Chromosome: 19
• Chromosome location: 19q13.41

miRNA Show/Hide all (65)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1540735	hsa-miR-1294	CLIP-seq
MIRT1540736	hsa-miR-1976	CLIP-seq
MIRT1540737	hsa-miR-3064-3p	CLIP-seq
MIRT1540738	hsa-miR-3200-3p	CLIP-seq
MIRT1540739	hsa-miR-3545-3p	CLIP-seq
MIRT1540740	hsa-miR-3925-3p	CLIP-seq
MIRT1540741	hsa-miR-4316	CLIP-seq
MIRT1540742	hsa-miR-4502	CLIP-seq
MIRT1540743	hsa-miR-450b-5p	CLIP-seq
MIRT1540744	hsa-miR-4696	CLIP-seq
MIRT1540745	hsa-miR-4712-5p	CLIP-seq
MIRT1540746	hsa-miR-4715-3p	CLIP-seq
MIRT1540747	hsa-miR-4768-5p	CLIP-seq
MIRT1540748	hsa-miR-766	CLIP-seq
MIRT1540749	hsa-miR-770-5p	CLIP-seq
MIRT2163266	hsa-miR-1246	CLIP-seq
MIRT1540735	hsa-miR-1294	CLIP-seq
MIRT1540736	hsa-miR-1976	CLIP-seq
MIRT2163267	hsa-miR-198	CLIP-seq
MIRT2163268	hsa-miR-2964a-5p	CLIP-seq
MIRT1540737	hsa-miR-3064-3p	CLIP-seq
MIRT2163269	hsa-miR-3921	CLIP-seq
MIRT1540741	hsa-miR-4316	CLIP-seq
MIRT2163270	hsa-miR-4320	CLIP-seq
MIRT1540742	hsa-miR-4502	CLIP-seq
MIRT2163271	hsa-miR-4653-5p	CLIP-seq
MIRT1540745	hsa-miR-4712-5p	CLIP-seq
MIRT1540746	hsa-miR-4715-3p	CLIP-seq
MIRT2163272	hsa-miR-4729	CLIP-seq
MIRT2163273	hsa-miR-4766-5p	CLIP-seq
MIRT1540747	hsa-miR-4768-5p	CLIP-seq
MIRT2163274	hsa-miR-654-3p	CLIP-seq
MIRT1540749	hsa-miR-770-5p	CLIP-seq
MIRT1540735	hsa-miR-1294	CLIP-seq
MIRT1540736	hsa-miR-1976	CLIP-seq
MIRT1540737	hsa-miR-3064-3p	CLIP-seq
MIRT1540739	hsa-miR-3545-3p	CLIP-seq
MIRT1540740	hsa-miR-3925-3p	CLIP-seq
MIRT1540741	hsa-miR-4316	CLIP-seq
MIRT2382394	hsa-miR-4452	CLIP-seq
MIRT1540745	hsa-miR-4712-5p	CLIP-seq
MIRT1540746	hsa-miR-4715-3p	CLIP-seq
MIRT1540747	hsa-miR-4768-5p	CLIP-seq
MIRT2382395	hsa-miR-4776-3p	CLIP-seq
MIRT2382396	hsa-miR-486-5p	CLIP-seq
MIRT1540748	hsa-miR-766	CLIP-seq
MIRT1540749	hsa-miR-770-5p	CLIP-seq
MIRT2163266	hsa-miR-1246	CLIP-seq
MIRT2163267	hsa-miR-198	CLIP-seq
MIRT2163270	hsa-miR-4320	CLIP-seq
MIRT1540743	hsa-miR-450b-5p	CLIP-seq
MIRT2673262	hsa-miR-4652-3p	CLIP-seq
MIRT1540744	hsa-miR-4696	CLIP-seq
MIRT1540745	hsa-miR-4712-5p	CLIP-seq
MIRT1540749	hsa-miR-770-5p	CLIP-seq
MIRT2163266	hsa-miR-1246	CLIP-seq
MIRT2163267	hsa-miR-198	CLIP-seq
MIRT2163269	hsa-miR-3921	CLIP-seq
MIRT2163270	hsa-miR-4320	CLIP-seq
MIRT1540743	hsa-miR-450b-5p	CLIP-seq
MIRT2673262	hsa-miR-4652-3p	CLIP-seq
MIRT2163271	hsa-miR-4653-5p	CLIP-seq
MIRT1540744	hsa-miR-4696	CLIP-seq
MIRT1540745	hsa-miR-4712-5p	CLIP-seq
MIRT1540749	hsa-miR-770-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	37973953
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010468	Process	Regulation of gene expression	IEA
GO:0010558	Process	Negative regulation of macromolecule biosynthetic process	IEA
GO:0010629	Process	Negative regulation of gene expression	IDA	37973953
GO:0030154	Process	Cell differentiation	IDA	37973953
GO:0031016	Process	Pancreas development	IDA	37973953
GO:0046872	Function	Metal ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IEA

Other IDs

• MIM: 620970
• HGNC: 33230
• e!Ensembl: ENSG00000198482

Protein

• UniProt ID: Q8N4W9
• Protein name: Zinc finger protein 808
• Protein function: Transcriptional repressor that targets mainly transposable elements (PubMed:37973953). Primarily targets the long terminal repeat of endogenous retroviruses classified as MER11 elements which comprise subfamilies A, B and C (PubMed:37973953). Ma
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	343 → 365	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	567 → 589	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	791 → 813	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	427 → 449	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	651 → 673	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	875 → 897	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	847 → 869	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	819 → 841	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	399 → 421	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	315 → 337	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	763 → 785	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	595 → 617	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	539 → 561	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	623 → 645	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	707 → 729	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	455 → 477	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	511 → 533	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	287 → 309	Zinc finger, C2H2 type	Domain
  PF01352	KRAB	23 → 64	KRAB box	Family

• Tissue specificity: TISSUE SPECIFICITY: Broadly expressed. {ECO:0000269|PubMed:37973953}.
• Sequence:

  MLREEAAQKRKGKESGMALPQGRLTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL
  EAVDISSKHMMKEVLSTGQGNREVIHTGTLQRHQSYHIGDFCFQEIEKEIHNIEFQCQED
  ERNGHEAPTTKIKKLTGSTDQHDHRHAGNKPIKDQLGSSFYSHLPELHIFQIKGEIANQL
  EKSTSDASSVSTSQRISCRPQIHISNNYGNNPLNSSLLPQKQEVHMREKSFPCNESGKAF
  NCSSLLRKHQIPHLGDKQYKCDVCGKLFNHKQYLACHRRCHTGEKPYKCKECGKSFSYKS
  SLTCHHRLHTGVKPYKCNECGKVFRQNSALVIHKAIHTGEKPYKCNECGKAFNQQSHLSR
  HQRLHTGVKPYKCKICEKAFACHSYLANHTRIHSGEKTYKCNECGKAFNHQSSLARHHIL
  HTGEKPYKCEECDKVFSQKSTLERHKRIHTGEKPYKCKVCDTAFTCNSQLARHRRIHTGE
  KTYKCNECRKTFSRRSSLLCHRRLHSGEKPYKCNQCGNTFRHRASLVYHRRLHTLEKSYK
  CTVCNKVFMRNSVLAVHTRIHTAKKPYKCNECGKAFNQQSHLSRHRRLHTGEKPYKCEAC
  DKVFGQKSALESHKRIHTGEKPYRCQVCDTAFTWNSQLARHTRIHTGEKTYKCNECGKTF
  SYKSSLVWHRRLHGGEKSYKCKVCDKAFVCRSYVAKHTRIHSGMKPYKCNECSKTFSNRS
  SLVCHRRIHSGEKPYKCSECSKTFSQKATLLCHRRLHSGEKPYKCNDCGNTFRHWSSLVY
  HRRLHTGEKSYKCTVCDKAFVRNSYLARHIRIHTAEKPYKCNECGKAFNEQSHLSRHHRI
  HTGEKPYKCEACDKVFSRKSHLKRHRIIHTGEKPYKCNECGKAFSDRSTLIHHQAIHGIG
  KFD

• Sequence length: 903

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Pancreatic agenesis 3	Likely pathogenic	rs2514374700	RCV004771541	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
BREAST CARCINOMA	—	GWAS catalog	29698419	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	37359372	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	29698419	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Diabetes Mellitus	Diabetes mellitus	Pubtator	37897565	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Transient Neonatal 1	Diabetes mellitus transient neonatal	Pubtator	37897565	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for ZNF808.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZNF808.