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Gene Gene information from NCBI Gene database.
Entrez ID 7554
Gene name Zinc finger protein 8
Gene symbol ZNF8
Synonyms (NCBI Gene)
HF.18Zfp128
Chromosome 19
Chromosome location 19q13.43
miRNA miRNA information provided by mirtarbase database.
271 Show/Hide all (271)
miRTarBase ID miRNA Experiments Reference
MIRT650903 hsa-miR-6796-3p HITS-CLIP 23824327
MIRT650902 hsa-miR-1285-5p HITS-CLIP 23824327
MIRT650901 hsa-miR-6890-3p HITS-CLIP 23824327
MIRT650900 hsa-miR-6736-3p HITS-CLIP 23824327
MIRT650899 hsa-miR-1304-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14 Show/Hide all (14)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0003677 Function DNA binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
194532 13154 ENSG00000278129
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P17098
Protein name Zinc finger protein 8 (Zinc finger protein HF.18)
Protein function Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00096 zf-C2H2 257 → 279 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 341 → 363 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 285 → 307 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 467 → 489 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 397 → 419 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 369 → 391 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 313 → 335 Zinc finger, C2H2 type Domain
PF01352 KRAB 24 → 65 KRAB box Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously present in many human cell lines of different embryological derivation. {ECO:0000269|PubMed:2106481}.
Sequence
MDPEDEGVAGVMSVGPPAARLQEPVTFRDVAVDFTQEEWGQLDPTQRILYRDVMLETFGH
LLSIG
PELPKPEVISQLEQGTELWVAERGTTQGCHPAWEPRSESQASRKEEGLPEEEPSH
VTGREGFPTDAPYPTTLGKDRECQSQSLALKEQNNLKQLEFGLKEAPVQDQGYKTLRLRE
NCVLSSSPNPFPEISRGEYLYTYDSQITDSEHNSSLVSQQTGSPGKQPGENSDCHRDSSQ
AIPITELTKSQVQDKPYKCTDCGKSFNHNAHLTVHKRIHTGERPYMCKECGKAFSQNSSL
VQHERIH
TGDKPYKCAECGKSFCHSTHLTVHRRIHTGEKPYECQDCGRAFNQNSSLGRHK
RTH
TGEKPYTCSVCGKSFSRTTCLFLHLRTHTEERPYECNHCGKGFRHSSSLAQHQRKHA
GEKPFECRQRLIFEQTPALTKHEWTEALGCDPPLSQDERTHRSDRPFKCNQCGKCFIQSS
HLIRHQITH
TREEQPHGRSRRREQSSSRNSHLVQHQHPNSRKSSAGGAKAGQPESRALAL
FDIQKIMQEKNPVHVIGVEEPSVGASMLFDIREST
Sequence length 575
Interactions View interactions