ZNF75D (zinc finger protein 75D)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 7626
• Gene name: Zinc finger protein 75D
• Gene symbol: ZNF75D
• Synonyms (NCBI Gene): D8C6, ZKSCAN24, ZNF75, ZNF82, ZSCAN28
• Chromosome: X
• Chromosome location: Xq26.3
• Summary: This gene encodes a protein that likely functions as a transcription factor. The protein, which belongs to the ZNF75 family, includes an N-terminal SCAN domain, a KRAB box, and five C2H2-type zinc finger motifs. Another functional gene belonging to this f

miRNA Show/Hide all (127)

miRTarBase ID	miRNA	Experiments	Reference
MIRT528594	hsa-miR-6507-3p	PAR-CLIP	22012620
MIRT528593	hsa-miR-6796-3p	PAR-CLIP	22012620
MIRT528592	hsa-miR-1255b-2-3p	PAR-CLIP	22012620
MIRT528591	hsa-miR-4744	PAR-CLIP	22012620
MIRT528590	hsa-miR-4509	PAR-CLIP	22012620
MIRT528589	hsa-miR-4799-5p	PAR-CLIP	22012620
MIRT528590	hsa-miR-4509	PAR-CLIP	27292025
MIRT528591	hsa-miR-4744	PAR-CLIP	27292025
MIRT528589	hsa-miR-4799-5p	PAR-CLIP	27292025
MIRT528594	hsa-miR-6507-3p	PAR-CLIP	27292025
MIRT528593	hsa-miR-6796-3p	PAR-CLIP	27292025
MIRT528594	hsa-miR-6507-3p	PAR-CLIP	22012620
MIRT528593	hsa-miR-6796-3p	PAR-CLIP	22012620
MIRT528592	hsa-miR-1255b-2-3p	PAR-CLIP	22012620
MIRT528591	hsa-miR-4744	PAR-CLIP	22012620
MIRT528590	hsa-miR-4509	PAR-CLIP	22012620
MIRT528589	hsa-miR-4799-5p	PAR-CLIP	22012620
MIRT1538438	hsa-miR-103a	CLIP-seq
MIRT1538439	hsa-miR-107	CLIP-seq
MIRT1538440	hsa-miR-1184	CLIP-seq
MIRT1538441	hsa-miR-185	CLIP-seq
MIRT1538442	hsa-miR-204	CLIP-seq
MIRT1538443	hsa-miR-211	CLIP-seq
MIRT1538444	hsa-miR-218	CLIP-seq
MIRT1538445	hsa-miR-3150b-3p	CLIP-seq
MIRT1538446	hsa-miR-3617	CLIP-seq
MIRT1538447	hsa-miR-3924	CLIP-seq
MIRT1538448	hsa-miR-4283	CLIP-seq
MIRT1538449	hsa-miR-4287	CLIP-seq
MIRT1538450	hsa-miR-4289	CLIP-seq
MIRT1538451	hsa-miR-4306	CLIP-seq
MIRT1538452	hsa-miR-4489	CLIP-seq
MIRT1538453	hsa-miR-451b	CLIP-seq
MIRT1538454	hsa-miR-4536	CLIP-seq
MIRT1538455	hsa-miR-4644	CLIP-seq
MIRT1538456	hsa-miR-4668-5p	CLIP-seq
MIRT1538457	hsa-miR-4685-3p	CLIP-seq
MIRT1538458	hsa-miR-4727-3p	CLIP-seq
MIRT1538459	hsa-miR-4753-3p	CLIP-seq
MIRT1538460	hsa-miR-4768-5p	CLIP-seq
MIRT1538461	hsa-miR-4784	CLIP-seq
MIRT1538462	hsa-miR-545	CLIP-seq
MIRT1538463	hsa-miR-548aa	CLIP-seq
MIRT1538464	hsa-miR-581	CLIP-seq
MIRT1538465	hsa-miR-587	CLIP-seq
MIRT1538466	hsa-miR-641	CLIP-seq
MIRT1538467	hsa-miR-802	CLIP-seq
MIRT1538468	hsa-miR-942	CLIP-seq
MIRT2162680	hsa-miR-125a-5p	CLIP-seq
MIRT2162681	hsa-miR-125b	CLIP-seq
MIRT2162682	hsa-miR-1262	CLIP-seq
MIRT2162683	hsa-miR-1283	CLIP-seq
MIRT1538444	hsa-miR-218	CLIP-seq
MIRT2162684	hsa-miR-3160-5p	CLIP-seq
MIRT2162685	hsa-miR-337-3p	CLIP-seq
MIRT2162686	hsa-miR-34b	CLIP-seq
MIRT2162687	hsa-miR-3663-5p	CLIP-seq
MIRT2162688	hsa-miR-4319	CLIP-seq
MIRT2162689	hsa-miR-4477a	CLIP-seq
MIRT2162690	hsa-miR-4701-3p	CLIP-seq
MIRT2162691	hsa-miR-4703-3p	CLIP-seq
MIRT2162692	hsa-miR-4732-3p	CLIP-seq
MIRT1538459	hsa-miR-4753-3p	CLIP-seq
MIRT2162693	hsa-miR-4775	CLIP-seq
MIRT2162694	hsa-miR-590-3p	CLIP-seq
MIRT2162695	hsa-miR-636	CLIP-seq
MIRT2162696	hsa-miR-670	CLIP-seq
MIRT1538468	hsa-miR-942	CLIP-seq
MIRT2381790	hsa-miR-296-3p	CLIP-seq
MIRT2381791	hsa-miR-1245b-5p	CLIP-seq
MIRT2381792	hsa-miR-3142	CLIP-seq
MIRT2381793	hsa-miR-4659a-5p	CLIP-seq
MIRT2381794	hsa-miR-4659b-5p	CLIP-seq
MIRT2381795	hsa-miR-4776-3p	CLIP-seq
MIRT2381796	hsa-miR-502-5p	CLIP-seq
MIRT2381797	hsa-miR-513c	CLIP-seq
MIRT2381798	hsa-miR-514b-5p	CLIP-seq
MIRT2672897	hsa-miR-1207-3p	CLIP-seq
MIRT2672898	hsa-miR-1265	CLIP-seq
MIRT2672899	hsa-miR-1470	CLIP-seq
MIRT1538441	hsa-miR-185	CLIP-seq
MIRT2672900	hsa-miR-302a	CLIP-seq
MIRT2672901	hsa-miR-302b	CLIP-seq
MIRT2672902	hsa-miR-302c	CLIP-seq
MIRT2672903	hsa-miR-302d	CLIP-seq
MIRT2672904	hsa-miR-302e	CLIP-seq
MIRT2672905	hsa-miR-3117-5p	CLIP-seq
MIRT1538445	hsa-miR-3150b-3p	CLIP-seq
MIRT2672906	hsa-miR-372	CLIP-seq
MIRT2672907	hsa-miR-373	CLIP-seq
MIRT1538451	hsa-miR-4306	CLIP-seq
MIRT2672908	hsa-miR-4469	CLIP-seq
MIRT1538453	hsa-miR-451b	CLIP-seq
MIRT1538455	hsa-miR-4644	CLIP-seq
MIRT2672909	hsa-miR-4667-3p	CLIP-seq
MIRT1538459	hsa-miR-4753-3p	CLIP-seq
MIRT2672910	hsa-miR-4774-5p	CLIP-seq
MIRT2672911	hsa-miR-4781-3p	CLIP-seq
MIRT1538461	hsa-miR-4784	CLIP-seq
MIRT2672912	hsa-miR-4796-5p	CLIP-seq
MIRT2672913	hsa-miR-513b	CLIP-seq
MIRT2672914	hsa-miR-520a-3p	CLIP-seq
MIRT2672915	hsa-miR-520b	CLIP-seq
MIRT2672916	hsa-miR-520c-3p	CLIP-seq
MIRT2672917	hsa-miR-520d-3p	CLIP-seq
MIRT2672918	hsa-miR-520e	CLIP-seq
MIRT1538462	hsa-miR-545	CLIP-seq
MIRT2672919	hsa-miR-548n	CLIP-seq
MIRT2672920	hsa-miR-548t	CLIP-seq
MIRT2672921	hsa-miR-642a	CLIP-seq
MIRT2672922	hsa-miR-654-3p	CLIP-seq
MIRT2672923	hsa-miR-767-5p	CLIP-seq
MIRT2672897	hsa-miR-1207-3p	CLIP-seq
MIRT2672898	hsa-miR-1265	CLIP-seq
MIRT2672899	hsa-miR-1470	CLIP-seq
MIRT2672905	hsa-miR-3117-5p	CLIP-seq
MIRT2696326	hsa-miR-4457	CLIP-seq
MIRT2672908	hsa-miR-4469	CLIP-seq
MIRT2672909	hsa-miR-4667-3p	CLIP-seq
MIRT2672910	hsa-miR-4774-5p	CLIP-seq
MIRT2381796	hsa-miR-502-5p	CLIP-seq
MIRT2672913	hsa-miR-513b	CLIP-seq
MIRT2672919	hsa-miR-548n	CLIP-seq
MIRT2672920	hsa-miR-548t	CLIP-seq
MIRT2672921	hsa-miR-642a	CLIP-seq
MIRT2672922	hsa-miR-654-3p	CLIP-seq
MIRT2672923	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008270	Function	Zinc ion binding	NAS	8288223
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 314997
• HGNC: 13145
• e!Ensembl: ENSG00000186376

Protein

• UniProt ID: P51815
• Protein name: Zinc finger protein 75D (Zinc finger protein 75) (Zinc finger protein 82)
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	449 → 471	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	365 → 387	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	421 → 443	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	477 → 499	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	393 → 415	Zinc finger, C2H2 type	Domain
  PF01352	KRAB	234 → 275	KRAB box	Family
  PF02023	SCAN	45 → 134	SCAN domain	Domain

• Sequence:

  MAMRELNADSCSSPQMGAMWETSGSVKENSSQSKKYSTKIENLGPESACRHFWSFRYHEA
  TGPLETISQLQKLCHQWLRPEIHSKEQILEMLVLEQFLSILPKETQNWVQKHHPQNVKQA
  LVLVEFLQREPDGTKNEVTAHELGKEAVLLGGTAVAPGFKWKPAEPQPMGVFQKEYWNTY
  RVLQEQLGWNTHKETQPVYERAVHDQQMLALSEQKRIKHWKMASKLILPESLSLLTFEDV
  AVYFSEEEWQLLNPLEKTLYNDVMQDIYETVISLGLKLKNDTGNDHPISVSTSEIQTSGC
  EVSKKTRMKIAQKTMGRENPGDTHSVQKWHRAFPRKKRKKPATCKQELPKLMDLHGKGPT
  GEKPFKCQECGKSFRVSSDLIKHHRIHTGEKPYKCQQCDRRFRWSSDLNKHFMTHQGIKP
  YRCSWCGKSFSHNTNLHTHQRIHTGEKPFKCDECGKRFIQNSHLIKHQRTHTGEQPYTCS
  LCKRNFSRRSSLLRHQKLHRRREACLVSPN

• Sequence length: 510

Pathways

Reactome Pathway:

Generic Transcription Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Abnormality of neuronal migration	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

No strongly related genes found yet for ZNF75D.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZNF75D.