ZNF598 (zinc finger protein 598, E3 ubiquitin ligase)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 90850
• Gene name: Zinc finger protein 598, E3 ubiquitin ligase
• Gene symbol: ZNF598
• Synonyms (NCBI Gene): HEL2
• Chromosome: 16
• Chromosome location: 16p13.3
• Summary: Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mamm

miRNA Show/Hide all (190)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017723	hsa-miR-335-5p	Microarray	18185580
MIRT031687	hsa-miR-16-5p	Proteomics	18668040
MIRT051039	hsa-miR-17-5p	CLASH	23622248
MIRT050619	hsa-miR-20a-5p	CLASH	23622248
MIRT048355	hsa-miR-106a-5p	CLASH	23622248
MIRT047372	hsa-miR-34a-5p	CLASH	23622248
MIRT044306	hsa-miR-106b-5p	CLASH	23622248
MIRT043538	hsa-miR-331-3p	CLASH	23622248
MIRT039063	hsa-miR-769-3p	CLASH	23622248
MIRT037480	hsa-miR-744-5p	CLASH	23622248
MIRT715832	hsa-miR-4717-5p	HITS-CLIP	19536157
MIRT715831	hsa-miR-1972	HITS-CLIP	19536157
MIRT715830	hsa-miR-4650-5p	HITS-CLIP	19536157
MIRT715829	hsa-miR-4794	HITS-CLIP	19536157
MIRT715828	hsa-miR-664a-5p	HITS-CLIP	19536157
MIRT715827	hsa-miR-149-5p	HITS-CLIP	19536157
MIRT715826	hsa-miR-3064-5p	HITS-CLIP	19536157
MIRT715825	hsa-miR-6504-5p	HITS-CLIP	19536157
MIRT715824	hsa-miR-6790-3p	HITS-CLIP	19536157
MIRT715823	hsa-miR-6821-3p	HITS-CLIP	19536157
MIRT715822	hsa-miR-4772-5p	HITS-CLIP	19536157
MIRT715821	hsa-miR-4252	HITS-CLIP	19536157
MIRT715820	hsa-miR-3119	HITS-CLIP	19536157
MIRT715819	hsa-miR-7973	HITS-CLIP	19536157
MIRT715818	hsa-miR-6808-3p	HITS-CLIP	19536157
MIRT549693	hsa-miR-548av-3p	PAR-CLIP	21572407
MIRT549692	hsa-miR-548g-3p	PAR-CLIP	21572407
MIRT549691	hsa-miR-3606-3p	PAR-CLIP	21572407
MIRT549689	hsa-miR-513a-3p	PAR-CLIP	21572407
MIRT549690	hsa-miR-513c-3p	PAR-CLIP	21572407
MIRT549688	hsa-miR-577	PAR-CLIP	21572407
MIRT549687	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT549686	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT549685	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT549684	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT549683	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT549682	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT549680	hsa-miR-4699-5p	PAR-CLIP	21572407
MIRT549681	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT549679	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT549678	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT549677	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT549676	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT549675	hsa-miR-6853-5p	PAR-CLIP	21572407
MIRT549674	hsa-miR-5681b	PAR-CLIP	21572407
MIRT549672	hsa-miR-4709-3p	PAR-CLIP	21572407
MIRT549673	hsa-miR-548aw	PAR-CLIP	21572407
MIRT549671	hsa-miR-518a-5p	PAR-CLIP	21572407
MIRT549670	hsa-miR-527	PAR-CLIP	21572407
MIRT549669	hsa-miR-6821-5p	PAR-CLIP	21572407
MIRT715832	hsa-miR-4717-5p	HITS-CLIP	19536157
MIRT715831	hsa-miR-1972	HITS-CLIP	19536157
MIRT715830	hsa-miR-4650-5p	HITS-CLIP	19536157
MIRT715829	hsa-miR-4794	HITS-CLIP	19536157
MIRT715828	hsa-miR-664a-5p	HITS-CLIP	19536157
MIRT715827	hsa-miR-149-5p	HITS-CLIP	19536157
MIRT715826	hsa-miR-3064-5p	HITS-CLIP	19536157
MIRT715825	hsa-miR-6504-5p	HITS-CLIP	19536157
MIRT715824	hsa-miR-6790-3p	HITS-CLIP	19536157
MIRT715823	hsa-miR-6821-3p	HITS-CLIP	19536157
MIRT715822	hsa-miR-4772-5p	HITS-CLIP	19536157
MIRT715821	hsa-miR-4252	HITS-CLIP	19536157
MIRT715820	hsa-miR-3119	HITS-CLIP	19536157
MIRT715819	hsa-miR-7973	HITS-CLIP	19536157
MIRT715818	hsa-miR-6808-3p	HITS-CLIP	19536157
MIRT549693	hsa-miR-548av-3p	PAR-CLIP	21572407
MIRT549692	hsa-miR-548g-3p	PAR-CLIP	21572407
MIRT549691	hsa-miR-3606-3p	PAR-CLIP	21572407
MIRT549689	hsa-miR-513a-3p	PAR-CLIP	21572407
MIRT549690	hsa-miR-513c-3p	PAR-CLIP	21572407
MIRT549688	hsa-miR-577	PAR-CLIP	21572407
MIRT549687	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT549686	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT549685	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT549684	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT549683	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT549682	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT549680	hsa-miR-4699-5p	PAR-CLIP	21572407
MIRT549681	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT549679	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT549678	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT549677	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT549676	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT549675	hsa-miR-6853-5p	PAR-CLIP	21572407
MIRT549674	hsa-miR-5681b	PAR-CLIP	21572407
MIRT549672	hsa-miR-4709-3p	PAR-CLIP	21572407
MIRT549673	hsa-miR-548aw	PAR-CLIP	21572407
MIRT549671	hsa-miR-518a-5p	PAR-CLIP	21572407
MIRT549670	hsa-miR-527	PAR-CLIP	21572407
MIRT549669	hsa-miR-6821-5p	PAR-CLIP	21572407
MIRT1531378	hsa-miR-3941	CLIP-seq
MIRT1531379	hsa-miR-4504	CLIP-seq
MIRT1531380	hsa-miR-452	CLIP-seq
MIRT1531381	hsa-miR-466	CLIP-seq
MIRT1531382	hsa-miR-4672	CLIP-seq
MIRT1531383	hsa-miR-4676-3p	CLIP-seq
MIRT1531384	hsa-miR-4677-3p	CLIP-seq
MIRT1531385	hsa-miR-4679	CLIP-seq
MIRT1531386	hsa-miR-4731-3p	CLIP-seq
MIRT1531387	hsa-miR-4801	CLIP-seq
MIRT1531388	hsa-miR-542-3p	CLIP-seq
MIRT2160614	hsa-miR-1184	CLIP-seq
MIRT2160615	hsa-miR-1202	CLIP-seq
MIRT2160616	hsa-miR-149	CLIP-seq
MIRT2160617	hsa-miR-3122	CLIP-seq
MIRT2160618	hsa-miR-3194-5p	CLIP-seq
MIRT2160619	hsa-miR-3689a-3p	CLIP-seq
MIRT2160620	hsa-miR-3689c	CLIP-seq
MIRT2160621	hsa-miR-3913-5p	CLIP-seq
MIRT2160622	hsa-miR-3921	CLIP-seq
MIRT2160623	hsa-miR-3972	CLIP-seq
MIRT2160624	hsa-miR-4649-3p	CLIP-seq
MIRT2160625	hsa-miR-4653-5p	CLIP-seq
MIRT2160626	hsa-miR-4687-5p	CLIP-seq
MIRT2160627	hsa-miR-4728-5p	CLIP-seq
MIRT2160628	hsa-miR-4758-3p	CLIP-seq
MIRT2160629	hsa-miR-4776-3p	CLIP-seq
MIRT2379883	hsa-miR-127-5p	CLIP-seq
MIRT2379884	hsa-miR-4635	CLIP-seq
MIRT2379885	hsa-miR-494	CLIP-seq
MIRT2379886	hsa-miR-526b	CLIP-seq
MIRT2379887	hsa-miR-543	CLIP-seq
MIRT2466413	hsa-miR-1273c	CLIP-seq
MIRT2466414	hsa-miR-3176	CLIP-seq
MIRT2466415	hsa-miR-3683	CLIP-seq
MIRT2466416	hsa-miR-3922-3p	CLIP-seq
MIRT2466417	hsa-miR-4701-5p	CLIP-seq
MIRT2466418	hsa-miR-588	CLIP-seq
MIRT2160614	hsa-miR-1184	CLIP-seq
MIRT2672018	hsa-miR-1207-5p	CLIP-seq
MIRT2672019	hsa-miR-1227	CLIP-seq
MIRT2672020	hsa-miR-1269	CLIP-seq
MIRT2672021	hsa-miR-1269b	CLIP-seq
MIRT2672022	hsa-miR-1288	CLIP-seq
MIRT2672023	hsa-miR-1827	CLIP-seq
MIRT2672024	hsa-miR-1909	CLIP-seq
MIRT2160617	hsa-miR-3122	CLIP-seq
MIRT2672025	hsa-miR-3136-3p	CLIP-seq
MIRT2672026	hsa-miR-3141	CLIP-seq
MIRT2672027	hsa-miR-3656	CLIP-seq
MIRT2672028	hsa-miR-3659	CLIP-seq
MIRT2160619	hsa-miR-3689a-3p	CLIP-seq
MIRT2160620	hsa-miR-3689c	CLIP-seq
MIRT2160621	hsa-miR-3913-5p	CLIP-seq
MIRT2160622	hsa-miR-3921	CLIP-seq
MIRT2672029	hsa-miR-4515	CLIP-seq
MIRT2160624	hsa-miR-4649-3p	CLIP-seq
MIRT2672030	hsa-miR-4651	CLIP-seq
MIRT2160625	hsa-miR-4653-5p	CLIP-seq
MIRT2672031	hsa-miR-4658	CLIP-seq
MIRT2160626	hsa-miR-4687-5p	CLIP-seq
MIRT2160627	hsa-miR-4728-5p	CLIP-seq
MIRT2672032	hsa-miR-4740-5p	CLIP-seq
MIRT2160628	hsa-miR-4758-3p	CLIP-seq
MIRT2672033	hsa-miR-4758-5p	CLIP-seq
MIRT2672034	hsa-miR-4763-3p	CLIP-seq
MIRT2672035	hsa-miR-566	CLIP-seq
MIRT2672036	hsa-miR-574-5p	CLIP-seq
MIRT2672037	hsa-miR-608	CLIP-seq
MIRT2672038	hsa-miR-648	CLIP-seq
MIRT2672039	hsa-miR-940	CLIP-seq
MIRT2160614	hsa-miR-1184	CLIP-seq
MIRT2160615	hsa-miR-1202	CLIP-seq
MIRT2672018	hsa-miR-1207-5p	CLIP-seq
MIRT2160616	hsa-miR-149	CLIP-seq
MIRT2672023	hsa-miR-1827	CLIP-seq
MIRT2672024	hsa-miR-1909	CLIP-seq
MIRT2160617	hsa-miR-3122	CLIP-seq
MIRT2672025	hsa-miR-3136-3p	CLIP-seq
MIRT2160618	hsa-miR-3194-5p	CLIP-seq
MIRT2672028	hsa-miR-3659	CLIP-seq
MIRT2160619	hsa-miR-3689a-3p	CLIP-seq
MIRT2160620	hsa-miR-3689c	CLIP-seq
MIRT2160621	hsa-miR-3913-5p	CLIP-seq
MIRT2160622	hsa-miR-3921	CLIP-seq
MIRT2160623	hsa-miR-3972	CLIP-seq
MIRT2160624	hsa-miR-4649-3p	CLIP-seq
MIRT2672030	hsa-miR-4651	CLIP-seq
MIRT2160625	hsa-miR-4653-5p	CLIP-seq
MIRT2672031	hsa-miR-4658	CLIP-seq
MIRT2160626	hsa-miR-4687-5p	CLIP-seq
MIRT2160627	hsa-miR-4728-5p	CLIP-seq
MIRT2160628	hsa-miR-4758-3p	CLIP-seq
MIRT2672033	hsa-miR-4758-5p	CLIP-seq
MIRT2672034	hsa-miR-4763-3p	CLIP-seq
MIRT2160629	hsa-miR-4776-3p	CLIP-seq
MIRT2672035	hsa-miR-566	CLIP-seq
MIRT2672036	hsa-miR-574-5p	CLIP-seq
MIRT2672037	hsa-miR-608	CLIP-seq
MIRT2672039	hsa-miR-940	CLIP-seq

Gene ontology (GO) Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	28065601, 28132843, 28685749, 33053355, 33961781, 35271311, 36931259
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	28757607
GO:0005829	Component	Cytosol	IEA
GO:0006417	Process	Regulation of translation	IEA
GO:0006513	Process	Protein monoubiquitination	IDA	28065601
GO:0008270	Function	Zinc ion binding	IEA
GO:0016567	Process	Protein ubiquitination	IBA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016567	Process	Protein ubiquitination	IMP	28132843
GO:0016740	Function	Transferase activity	IEA
GO:0022626	Component	Cytosolic ribosome	IDA	30293783, 36302773
GO:0032790	Process	Ribosome disassembly	IDA	36302773
GO:0043022	Function	Ribosome binding	IBA
GO:0043022	Function	Ribosome binding	IDA	28065601, 28132843
GO:0045947	Process	Negative regulation of translational initiation	IDA	32726578
GO:0045947	Process	Negative regulation of translational initiation	IDA	28065601
GO:0046872	Function	Metal ion binding	IEA
GO:0055106	Function	Ubiquitin-protein transferase regulator activity	IDA	30293783
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	28065601, 28685749, 30293783, 36302773
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IMP	28132843
GO:0070534	Process	Protein K63-linked ubiquitination	IDA	36302773
GO:0072344	Process	Rescue of stalled ribosome	IBA
GO:0072344	Process	Rescue of stalled ribosome	IDA	32726578
GO:0072344	Process	Rescue of stalled ribosome	IDA	28065601, 28685749, 30293783, 32579943, 33581075, 36302773
GO:0072344	Process	Rescue of stalled ribosome	IEA
GO:0072344	Process	Rescue of stalled ribosome	IMP	28132843, 32099016
GO:0140517	Function	Protein-RNA adaptor activity	IDA	32726578
GO:0170011	Function	Stalled ribosome sensor activity	IDA	30293783
GO:1990116	Process	Ribosome-associated ubiquitin-dependent protein catabolic process	IMP	32099016

Other IDs

• MIM: 617508
• HGNC: 28079
• e!Ensembl: ENSG00000167962

Protein

• UniProt ID: Q86UK7
• Protein name: E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598)
• Protein function: E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains (PubMed:28065601, PubMed:2813284
• Sequence:

  MAAAGGAEGRRAALEAAAAAAPERGGGSCVLCCGDLEATALGRCDHPVCYRCSTKMRVLC
  EQRYCAVCREELRQVVFGKKLPAFATIPIHQLQHEKKYDIYFADGKVYALYRQLLQHECP
  RCPELPPFSLFGDLEQHMRRQHELFCCRLCLQHLQIFTYERKWYSRKDLARHRMQGDPDD
  TSHRGHPLCKFCDERYLDNDELLKHLRRDHYFCHFCDSDGAQDYYSDYAYLREHFREKHF
  LCEEGRCSTEQFTHAFRTEIDLKAHRTACHSRSRAEARQNRHIDLQFSYAPRHSRRNEGV
  VGGEDYEEVDRYSRQGRVARAGTRGAQQSRRGSWRYKREEEDREVAAAVRASVAAQQQEE
  ARRSEDQEEGGRPKKEEAAARGPEDPRGPRRSPRTQGEGPGPKETSTNGPVSQEAFSVTG
  PAAPGCVGVPGALPPPSPKLKDEDFPSLSASTSSSCSTAATPGPVGLALPYAIPARGRSA
  FQEEDFPALVSSVPKPGTAPTSLVSAWNSSSSSKKVAQPPLSAQATGSGQPTRKAGKGSR
  GGRKGGPPFTQEEEEDGGPALQELLSTRPTGSVSSTLGLASIQPSKVGKKKKVGSEKPGT
  TLPQPPPATCPPGALQAPEAPASRAEGPVAVVVNGHTEGPAPARSAPKEPPGLPRPLGSF
  PCPTPQEDFPALGGPCPPRMPPPPGFSAVVLLKGTPPPPPPGLVPPISKPPPGFSGLLPS
  PHPACVPSPATTTTTKAPRLLPAPRAYLVPENFRERNLQLIQSIRDFLQSDEARFSEFKS
  HSGEFRQGLISAAQYYKSCRDLLGENFQKVFNELLVLLPDTAKQQELLSAHTDFCNREKP
  LSTKSKKNKKSAWQATTQQAGLDCRVCPTCQQVLAHGDASSHQALHAARDDDFPSLQAIA
  RIIT

• Sequence length: 904

Related Genes

No strongly related genes found yet for ZNF598.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZNF598.