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Gene Gene information from NCBI Gene database.
Entrez ID 79230
Gene name Zinc finger protein 557
Gene symbol ZNF557
Synonyms (NCBI Gene)
-
Chromosome 19
Chromosome location 19p13.2
miRNA miRNA information provided by mirtarbase database.
916 Show/Hide all (916)
miRTarBase ID miRNA Experiments Reference
MIRT050221 hsa-miR-25-3p CLASH 23622248
MIRT609851 hsa-miR-8485 HITS-CLIP 23824327
MIRT609850 hsa-miR-603 HITS-CLIP 23824327
MIRT609849 hsa-miR-4639-3p HITS-CLIP 23824327
MIRT609848 hsa-miR-7110-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
11 Show/Hide all (11)
GO ID Ontology Definition Evidence Reference
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 32296183, 32814053
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8N988
Protein name Zinc finger protein 557
Protein function May be involved in transcriptional regulation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00096 zf-C2H2 201 → 223 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 397 → 419 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 369 → 391 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 229 → 251 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 285 → 307 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 146 → 167 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 173 → 195 Zinc finger, C2H2 type Domain
PF01352 KRAB 35 → 76 KRAB box Family
PF13465 zf-H2C2_2 327 → 352 Domain
Sequence
MAAVVLPPTAASQREGHTEGGELVNELLKSWLKGLVTFEDVAVEFTQEEWALLDPAQRTL
YRDVMLENCRNLASLG
NQVDKPRLISQLEQEDKVMTEERGILSGTCPDVENPFKAKGLTP
KLHVFRKEQSRNMKMERNHLGATLNECNQCFKVFSTKSSLTRHRKIHTGERPYGCSECGK
SYSSRSYLAVHKRIH
NGEKPYECNDCGKTFSSRSYLTVHKRIHNGEKPYECSDCGKTFSN
SSYLRPHLRIH
TGEKPYKCNQCFREFRTQSIFTRHKRVHTGEGHYVCNQCGKAFGTRSSL
SSHYSIH
TGEYPYECHDCGRTFRRRSNLTQHIRTHTGEKPYTCNECGKSFTNSFSLTIHR
RIHNGEKSYECSDCGKSFNVLSSVKKHMRTHTGKKPYECNYCGKSFTSNSYLSVHTRMHN
RQM
Sequence length 423
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Generic Transcription Pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Thyroid cancer, nonmedullary, 1 Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations