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Gene Gene information from NCBI Gene database.
Entrez ID 25888
Gene name Zinc finger protein 473
Gene symbol ZNF473
Synonyms (NCBI Gene)
ZFP100ZN473
Chromosome 19
Chromosome location 19q13.33
Summary This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein, a component of the U7 snRNP complex, plays a role in histone 3`-end pre-mRNA processing and may be required for cell cycle progression to S phase. Ex
miRNA miRNA information provided by mirtarbase database.
220 Show/Hide all (220)
miRTarBase ID miRNA Experiments Reference
MIRT027502 hsa-miR-98-5p Microarray 19088304
MIRT043880 hsa-miR-378a-3p CLASH 23622248
MIRT036944 hsa-miR-877-3p CLASH 23622248
MIRT200713 hsa-miR-411-5p PAR-CLIP 20371350
MIRT200717 hsa-miR-4257 PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13 Show/Hide all (13)
GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 16189514, 16714279, 25416956, 25910212, 26871637, 31515488, 32296183
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
617908 23239 ENSG00000142528
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8WTR7
Protein name Zinc finger protein 473 (Zinc finger protein 100 homolog) (Zfp-100)
Protein function Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycl
PDB 2EMB , 2EMC , 2EME , 2EOU , 2EOX , 2EOY , 2EOZ , 2YRH , 2YRJ , 2YSV , 2YTD , 2YTE , 2YTT , 2YU5 , 9AZI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00096 zf-C2H2 786 → 808 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 320 → 342 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 702 → 724 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 646 → 668 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 758 → 780 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 459 → 481 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 730 → 752 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 674 → 696 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 814 → 836 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 375 → 397 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 591 → 613 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 431 → 453 Zinc finger, C2H2 type Domain
PF01352 KRAB 5 → 46 KRAB box Family
PF13894 zf-C2H2_4 209 → 232 Domain
Sequence
MAEEFVTLKDVGMDFTLGDWEQLGLEQGDTFWDTALDNCQDLFLLDPPRPNLTSHPDGSE
DLEPLAGGSPEATSPDVTETKNSPLMEDFFEEGFSQEIIEMLSKDGFWNSNFGEACIEDT
WLDSLLGDPESLLRSDIATNGESPTECKSHELKRGLSPVSTVSTGEDSMVHNVSEKTLTP
AKSKEYRGEFFSYSDHSQQDSVQEGEKPYQCSECGKSFSGSYRLTQHWITHTREKPTVHQ
ECEQGFDRNASLSVYPKTHTGYKFYVCNEYGTTFSQSTYLWHQKTHTGEKPCKSQDSDHP
PSHDTQPGEHQKTHTDSKSYNCNECGKAFTRIFHLTRHQKIHTRKRYECSKCQATFNLRK
HLIQHQKTHAAKTTSECQECGKIFRHSSLLIEHQALHAGEEPYKCNERGKSFRHNSTLKI
HQRVHSGEKPYKCSECGKAFHRHTHLNEHRRIHTGYRPHKCQECVRSFSRPSHLMRHQAI
H
TAEKPYSCAECKETFSDNNRLVQHQKMHTVKTPYECQECGERFICGSTLKCHESVHARE
KQGFFVSGKILDQNPEQKEKCFKCNKCEKTFSCSKYLTQHERIHTRGVKPFECDQCGKAF
GQSTRLIHHQRIH
SRVRLYKWGEQGKAISSASLIKLQSFHTKEHPFKCNECGKTFSHSAH
LSKHQLIH
AGENPFKCSKCDRVFTQRNYLVQHERTHARKKPLVCNECGKTFRQSSCLSKH
QRIH
SGEKPYVCDYCGKAFGLSAELVRHQRIHTGEKPYVCQECGKAFTQSSCLSIHRRVH
TGEKPYRCGECGKAFAQKANLTQHQRIHTGEKPYSCNVCGKAFVLSAHLNQHLRVHTQET
LYQCQRCQKAFRCHSSLSRHQRVHNKQQYCL
Sequence length 871
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
SLBP independent Processing of Histone Pre-mRNAs
Generic Transcription Pathway
RNA Polymerase II Transcription Termination
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Breast ductal adenocarcinoma Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Bone Diseases Metabolic Bone disease Pubtator 26390436 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Osteoporosis Osteoporosis Pubtator 26390436 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only