ZNF473 (zinc finger protein 473)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 25888 |
| Gene name | Zinc finger protein 473 |
| Gene symbol | ZNF473 |
| Synonyms (NCBI Gene) |
ZFP100ZN473
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| Chromosome | 19 |
| Chromosome location | 19q13.33 |
| Summary | This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein, a component of the U7 snRNP complex, plays a role in histone 3`-end pre-mRNA processing and may be required for cell cycle progression to S phase. Ex |
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miRNA
miRNA information provided by mirtarbase database.
220
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q8WTR7 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein name | Zinc finger protein 473 (Zinc finger protein 100 homolog) (Zfp-100) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein function | Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycl | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PDB | 2EMB , 2EMC , 2EME , 2EOU , 2EOX , 2EOY , 2EOZ , 2YRH , 2YRJ , 2YSV , 2YTD , 2YTE , 2YTT , 2YU5 , 9AZI | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
MAEEFVTLKDVGMDFTLGDWEQLGLEQGDTFWDTALDNCQDLFLLDPPRPNLTSHPDGSE |
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| Sequence length | 871 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with ZNF473 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to ZNF473 (see Related Genes above), that are NOT already directly curated for ZNF473 itself -- a lead worth checking, not a confirmed association.
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