ZNF397 (zinc finger protein 397)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 84307
• Gene name: Zinc finger protein 397
• Gene symbol: ZNF397
• Synonyms (NCBI Gene): ZNF47, ZSCAN15
• Chromosome: 18
• Chromosome location: 18q12.2
• Summary: This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can r

miRNA Show/Hide all (170)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1523854	hsa-miR-1224-3p	CLIP-seq
MIRT1523855	hsa-miR-1226	CLIP-seq
MIRT1523856	hsa-miR-128	CLIP-seq
MIRT1523857	hsa-miR-1302	CLIP-seq
MIRT1523858	hsa-miR-1343	CLIP-seq
MIRT1523859	hsa-miR-144	CLIP-seq
MIRT1523860	hsa-miR-146b-3p	CLIP-seq
MIRT1523861	hsa-miR-2355-5p	CLIP-seq
MIRT1523862	hsa-miR-27a	CLIP-seq
MIRT1523863	hsa-miR-27b	CLIP-seq
MIRT1523864	hsa-miR-3065-5p	CLIP-seq
MIRT1523865	hsa-miR-3074-5p	CLIP-seq
MIRT1523866	hsa-miR-3124-3p	CLIP-seq
MIRT1523867	hsa-miR-3173-5p	CLIP-seq
MIRT1523868	hsa-miR-3194-3p	CLIP-seq
MIRT1523869	hsa-miR-342-3p	CLIP-seq
MIRT1523870	hsa-miR-3679-3p	CLIP-seq
MIRT1523871	hsa-miR-370	CLIP-seq
MIRT1523872	hsa-miR-377	CLIP-seq
MIRT1523873	hsa-miR-378g	CLIP-seq
MIRT1523874	hsa-miR-384	CLIP-seq
MIRT1523875	hsa-miR-3973	CLIP-seq
MIRT1523876	hsa-miR-4286	CLIP-seq
MIRT1523877	hsa-miR-4292	CLIP-seq
MIRT1523878	hsa-miR-4298	CLIP-seq
MIRT1523879	hsa-miR-4437	CLIP-seq
MIRT1523880	hsa-miR-455-3p	CLIP-seq
MIRT1523881	hsa-miR-4674	CLIP-seq
MIRT1523882	hsa-miR-4704-5p	CLIP-seq
MIRT1523883	hsa-miR-4719	CLIP-seq
MIRT1523884	hsa-miR-4763-5p	CLIP-seq
MIRT1523885	hsa-miR-4786-3p	CLIP-seq
MIRT1523886	hsa-miR-495	CLIP-seq
MIRT1523887	hsa-miR-513a-5p	CLIP-seq
MIRT1523888	hsa-miR-513b	CLIP-seq
MIRT1523889	hsa-miR-515-3p	CLIP-seq
MIRT1523890	hsa-miR-519e	CLIP-seq
MIRT1523891	hsa-miR-874	CLIP-seq
MIRT1523892	hsa-miR-1264	CLIP-seq
MIRT2158338	hsa-miR-1200	CLIP-seq
MIRT1523855	hsa-miR-1226	CLIP-seq
MIRT2158339	hsa-miR-1245b-3p	CLIP-seq
MIRT1523857	hsa-miR-1302	CLIP-seq
MIRT2158340	hsa-miR-139-3p	CLIP-seq
MIRT2158341	hsa-miR-181a	CLIP-seq
MIRT2158342	hsa-miR-181b	CLIP-seq
MIRT2158343	hsa-miR-181c	CLIP-seq
MIRT2158344	hsa-miR-181d	CLIP-seq
MIRT2158345	hsa-miR-223	CLIP-seq
MIRT2158346	hsa-miR-3117-5p	CLIP-seq
MIRT2158347	hsa-miR-3153	CLIP-seq
MIRT2158348	hsa-miR-323-3p	CLIP-seq
MIRT2158349	hsa-miR-330-3p	CLIP-seq
MIRT1523869	hsa-miR-342-3p	CLIP-seq
MIRT2158350	hsa-miR-3613-3p	CLIP-seq
MIRT2158351	hsa-miR-3662	CLIP-seq
MIRT2158352	hsa-miR-371b-5p	CLIP-seq
MIRT1523872	hsa-miR-377	CLIP-seq
MIRT1523875	hsa-miR-3973	CLIP-seq
MIRT2158353	hsa-miR-4262	CLIP-seq
MIRT1523878	hsa-miR-4298	CLIP-seq
MIRT2158354	hsa-miR-4324	CLIP-seq
MIRT2158355	hsa-miR-4328	CLIP-seq
MIRT2158356	hsa-miR-4329	CLIP-seq
MIRT2158357	hsa-miR-433	CLIP-seq
MIRT1523880	hsa-miR-455-3p	CLIP-seq
MIRT2158358	hsa-miR-4646-5p	CLIP-seq
MIRT2158359	hsa-miR-4668-5p	CLIP-seq
MIRT2158360	hsa-miR-4698	CLIP-seq
MIRT2158361	hsa-miR-485-3p	CLIP-seq
MIRT1523889	hsa-miR-515-3p	CLIP-seq
MIRT1523890	hsa-miR-519e	CLIP-seq
MIRT2158362	hsa-miR-542-3p	CLIP-seq
MIRT2158363	hsa-miR-544b	CLIP-seq
MIRT2158364	hsa-miR-664	CLIP-seq
MIRT2158365	hsa-miR-888	CLIP-seq
MIRT2377819	hsa-miR-1208	CLIP-seq
MIRT1523855	hsa-miR-1226	CLIP-seq
MIRT2158339	hsa-miR-1245b-3p	CLIP-seq
MIRT2377820	hsa-miR-1260	CLIP-seq
MIRT2377821	hsa-miR-1260b	CLIP-seq
MIRT1523857	hsa-miR-1302	CLIP-seq
MIRT2158341	hsa-miR-181a	CLIP-seq
MIRT2158342	hsa-miR-181b	CLIP-seq
MIRT2158343	hsa-miR-181c	CLIP-seq
MIRT2158344	hsa-miR-181d	CLIP-seq
MIRT2377822	hsa-miR-188-3p	CLIP-seq
MIRT2377823	hsa-miR-2116	CLIP-seq
MIRT2158345	hsa-miR-223	CLIP-seq
MIRT2158346	hsa-miR-3117-5p	CLIP-seq
MIRT2377824	hsa-miR-3156-3p	CLIP-seq
MIRT2377825	hsa-miR-3189-5p	CLIP-seq
MIRT2158348	hsa-miR-323-3p	CLIP-seq
MIRT1523869	hsa-miR-342-3p	CLIP-seq
MIRT2158350	hsa-miR-3613-3p	CLIP-seq
MIRT2158351	hsa-miR-3662	CLIP-seq
MIRT2158352	hsa-miR-371b-5p	CLIP-seq
MIRT1523872	hsa-miR-377	CLIP-seq
MIRT2377826	hsa-miR-3940-5p	CLIP-seq
MIRT1523875	hsa-miR-3973	CLIP-seq
MIRT2158353	hsa-miR-4262	CLIP-seq
MIRT1523878	hsa-miR-4298	CLIP-seq
MIRT2377827	hsa-miR-4301	CLIP-seq
MIRT2377828	hsa-miR-4323	CLIP-seq
MIRT2158355	hsa-miR-4328	CLIP-seq
MIRT2377829	hsa-miR-4507	CLIP-seq
MIRT1523880	hsa-miR-455-3p	CLIP-seq
MIRT2377830	hsa-miR-4652-3p	CLIP-seq
MIRT2377831	hsa-miR-4677-5p	CLIP-seq
MIRT2158360	hsa-miR-4698	CLIP-seq
MIRT2377832	hsa-miR-4762-3p	CLIP-seq
MIRT2158361	hsa-miR-485-3p	CLIP-seq
MIRT2377833	hsa-miR-490-3p	CLIP-seq
MIRT1523889	hsa-miR-515-3p	CLIP-seq
MIRT1523890	hsa-miR-519e	CLIP-seq
MIRT2158362	hsa-miR-542-3p	CLIP-seq
MIRT2377834	hsa-miR-649	CLIP-seq
MIRT2377835	hsa-miR-661	CLIP-seq
MIRT2158365	hsa-miR-888	CLIP-seq
MIRT1523857	hsa-miR-1302	CLIP-seq
MIRT1523869	hsa-miR-342-3p	CLIP-seq
MIRT2158350	hsa-miR-3613-3p	CLIP-seq
MIRT2158352	hsa-miR-371b-5p	CLIP-seq
MIRT1523872	hsa-miR-377	CLIP-seq
MIRT1523875	hsa-miR-3973	CLIP-seq
MIRT1523878	hsa-miR-4298	CLIP-seq
MIRT1523880	hsa-miR-455-3p	CLIP-seq
MIRT1523889	hsa-miR-515-3p	CLIP-seq
MIRT1523890	hsa-miR-519e	CLIP-seq
MIRT2158365	hsa-miR-888	CLIP-seq
MIRT1523855	hsa-miR-1226	CLIP-seq
MIRT2158346	hsa-miR-3117-5p	CLIP-seq
MIRT2158347	hsa-miR-3153	CLIP-seq
MIRT2670189	hsa-miR-3182	CLIP-seq
MIRT2377825	hsa-miR-3189-5p	CLIP-seq
MIRT2158348	hsa-miR-323-3p	CLIP-seq
MIRT2158349	hsa-miR-330-3p	CLIP-seq
MIRT2158351	hsa-miR-3662	CLIP-seq
MIRT2670190	hsa-miR-3686	CLIP-seq
MIRT1523872	hsa-miR-377	CLIP-seq
MIRT2670191	hsa-miR-3920	CLIP-seq
MIRT2377828	hsa-miR-4323	CLIP-seq
MIRT2670192	hsa-miR-4475	CLIP-seq
MIRT1523880	hsa-miR-455-3p	CLIP-seq
MIRT2158358	hsa-miR-4646-5p	CLIP-seq
MIRT2377830	hsa-miR-4652-3p	CLIP-seq
MIRT2670193	hsa-miR-4659a-3p	CLIP-seq
MIRT2670194	hsa-miR-4659b-3p	CLIP-seq
MIRT2158359	hsa-miR-4668-5p	CLIP-seq
MIRT2158360	hsa-miR-4698	CLIP-seq
MIRT2670195	hsa-miR-4742-3p	CLIP-seq
MIRT2377832	hsa-miR-4762-3p	CLIP-seq
MIRT2670196	hsa-miR-4778-5p	CLIP-seq
MIRT2158361	hsa-miR-485-3p	CLIP-seq
MIRT2377833	hsa-miR-490-3p	CLIP-seq
MIRT2670197	hsa-miR-498	CLIP-seq
MIRT1523887	hsa-miR-513a-5p	CLIP-seq
MIRT2670198	hsa-miR-630	CLIP-seq
MIRT2377834	hsa-miR-649	CLIP-seq
MIRT2670189	hsa-miR-3182	CLIP-seq
MIRT2670190	hsa-miR-3686	CLIP-seq
MIRT2670191	hsa-miR-3920	CLIP-seq
MIRT2377830	hsa-miR-4652-3p	CLIP-seq
MIRT2670193	hsa-miR-4659a-3p	CLIP-seq
MIRT2670194	hsa-miR-4659b-3p	CLIP-seq
MIRT2670195	hsa-miR-4742-3p	CLIP-seq
MIRT2377832	hsa-miR-4762-3p	CLIP-seq
MIRT2670196	hsa-miR-4778-5p	CLIP-seq
MIRT1523887	hsa-miR-513a-5p	CLIP-seq
MIRT2670198	hsa-miR-630	CLIP-seq

Gene ontology (GO) Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	20211142, 25416956, 26871637, 28514442, 31403225, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	12801647
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IDA	12801647
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IDA	12801647
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0015630	Component	Microtubule cytoskeleton	IEA
GO:0042803	Function	Protein homodimerization activity	IPI	12801647
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	12801647
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0046982	Function	Protein heterodimerization activity	IPI	12801647

Other IDs

• MIM: 609601
• HGNC: 18818
• e!Ensembl: ENSG00000186812

Protein

• UniProt ID: Q8NF99
• Protein name: Zinc finger protein 397 (Zinc finger and SCAN domain-containing protein 15) (Zinc finger protein 47)
• Protein function: Isoform 3 acts as a DNA-dependent transcriptional repressor.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	481 → 503	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	397 → 419	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	425 → 447	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	453 → 475	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	341 → 363	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	369 → 391	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	509 → 531	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	285 → 307	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	313 → 335	Zinc finger, C2H2 type	Domain
  PF02023	SCAN	46 → 135	SCAN domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed strongly in testis, moderately in skeletal muscle, pancreas and prostate, and weakly in heart, placenta, liver, kidney, spleen, thymus and small intestine. {ECO:0000269|PubMed:12801647}.
• Sequence:

  MAVESGVISTLIPQDPPEQELILVKVEDNFSWDEKFKQNGSTQSCQELFRQQFRKFCYQE
  TPGPREALSRLQELCYQWLMPELHTKEQILELLVLEQFLSILPEELQIWVQQHNPESGEE
  AVTLLEDLEREFDDPGQQVPASPQGPAVPWKDLTCLRASQESTDIHLQPLKTQLKSWKPC
  LSPKSDCENSETATKEGISEEKSQGLPQEPSFRGISEHESNLVWKQGSATGEKLRSPSQG
  GSFSQVIFTNKSLGKRDLYDEAERCLILTTDSIMCQKVPPEERPYRCDVCGHSFKQHSSL
  TQHQRIHTGEKPYKCNQCGKAFSLRSYLIIHQRIHSGEKAYECSECGKAFNQSSALIRHR
  KIHTGEKACKCNECGKAFSQSSYLIIHQRIHTGEKPYECNECGKTFSQSSKLIRHQRIHT
  GERPYECNECGKAFRQSSELITHQRIHSGEKPYECSECGKAFSLSSNLIRHQRIHSGEEP
  YQCNECGKTFKRSSALVQHQRIHSGDEAYICNECGKAFRHRSVLMRHQRVHTIK

• Sequence length: 534

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Cervical cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

No strongly related genes found yet for ZNF397.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZNF397.