ZNF383 (zinc finger protein 383)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 163087
• Gene name: Zinc finger protein 383
• Gene symbol: ZNF383
• Synonyms (NCBI Gene): HSD17, Zfp383
• Chromosome: 19
• Chromosome location: 19q13.12
• Summary: The protein encoded by this gene is a KRAB-related zinc finger protein that inhibits the transcription of some MAPK signaling pathway genes. The repressor activity resides in the KRAB domain of the encoded protein. [provided by RefSeq, Sep 2016]

miRNA Show/Hide all (204)

miRTarBase ID	miRNA	Experiments	Reference
MIRT042301	hsa-miR-484	CLASH	23622248
MIRT042301	hsa-miR-484	CLASH	23622248
MIRT693772	hsa-miR-4797-5p	HITS-CLIP	23313552
MIRT693771	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT693770	hsa-miR-5586-3p	HITS-CLIP	23313552
MIRT693769	hsa-miR-759	HITS-CLIP	23313552
MIRT693768	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT681248	hsa-miR-4537	HITS-CLIP	23313552
MIRT693767	hsa-miR-4252	HITS-CLIP	23313552
MIRT693766	hsa-miR-7703	HITS-CLIP	23313552
MIRT693765	hsa-miR-6890-3p	HITS-CLIP	23313552
MIRT693764	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT693763	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT693762	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT693761	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT693760	hsa-miR-18a-3p	HITS-CLIP	23313552
MIRT693759	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT693758	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT693757	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT693756	hsa-miR-612	HITS-CLIP	23313552
MIRT693755	hsa-miR-6860	HITS-CLIP	23313552
MIRT693754	hsa-miR-4290	HITS-CLIP	23313552
MIRT693753	hsa-miR-661	HITS-CLIP	23313552
MIRT693752	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT693750	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT693751	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT693749	hsa-miR-1229-3p	HITS-CLIP	23313552
MIRT681253	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT681252	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT681251	hsa-miR-4257	HITS-CLIP	23706177
MIRT681250	hsa-miR-6746-5p	HITS-CLIP	23706177
MIRT681249	hsa-miR-4680-5p	HITS-CLIP	23706177
MIRT681248	hsa-miR-4537	HITS-CLIP	23706177
MIRT681247	hsa-miR-1827	HITS-CLIP	23706177
MIRT681246	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT681245	hsa-miR-6086	HITS-CLIP	23706177
MIRT681244	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT681243	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681242	hsa-miR-3612	HITS-CLIP	23706177
MIRT681241	hsa-miR-650	HITS-CLIP	23706177
MIRT681240	hsa-miR-6771-5p	HITS-CLIP	23706177
MIRT681239	hsa-miR-7158-3p	HITS-CLIP	23706177
MIRT681238	hsa-miR-203b-3p	HITS-CLIP	23706177
MIRT681237	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT681236	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT637374	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT637374	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT631630	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT631629	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT631628	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT544550	hsa-miR-3163	PAR-CLIP	21572407
MIRT544551	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT544549	hsa-miR-5692b	PAR-CLIP	21572407
MIRT544548	hsa-miR-5692c	PAR-CLIP	21572407
MIRT544547	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT544546	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT544550	hsa-miR-3163	PAR-CLIP	21572407
MIRT544551	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT544549	hsa-miR-5692b	PAR-CLIP	21572407
MIRT544548	hsa-miR-5692c	PAR-CLIP	21572407
MIRT544547	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT544546	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT681247	hsa-miR-1827	PAR-CLIP	27292025
MIRT681253	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT681238	hsa-miR-203b-3p	PAR-CLIP	27292025
MIRT681244	hsa-miR-2467-3p	PAR-CLIP	27292025
MIRT681242	hsa-miR-3612	PAR-CLIP	27292025
MIRT681246	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT681251	hsa-miR-4257	PAR-CLIP	27292025
MIRT681248	hsa-miR-4537	PAR-CLIP	27292025
MIRT681237	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT681249	hsa-miR-4680-5p	PAR-CLIP	27292025
MIRT681245	hsa-miR-6086	PAR-CLIP	27292025
MIRT681243	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT681241	hsa-miR-650	PAR-CLIP	27292025
MIRT681252	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT681236	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT681250	hsa-miR-6746-5p	PAR-CLIP	27292025
MIRT681240	hsa-miR-6771-5p	PAR-CLIP	27292025
MIRT681239	hsa-miR-7158-3p	PAR-CLIP	27292025
MIRT693772	hsa-miR-4797-5p	HITS-CLIP	23313552
MIRT693771	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT693770	hsa-miR-5586-3p	HITS-CLIP	23313552
MIRT693769	hsa-miR-759	HITS-CLIP	23313552
MIRT693768	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT681248	hsa-miR-4537	HITS-CLIP	23313552
MIRT693767	hsa-miR-4252	HITS-CLIP	23313552
MIRT693766	hsa-miR-7703	HITS-CLIP	23313552
MIRT693765	hsa-miR-6890-3p	HITS-CLIP	23313552
MIRT693764	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT693763	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT693762	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT693761	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT693760	hsa-miR-18a-3p	HITS-CLIP	23313552
MIRT693759	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT693758	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT693757	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT693756	hsa-miR-612	HITS-CLIP	23313552
MIRT693755	hsa-miR-6860	HITS-CLIP	23313552
MIRT693754	hsa-miR-4290	HITS-CLIP	23313552
MIRT693753	hsa-miR-661	HITS-CLIP	23313552
MIRT693752	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT693750	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT693751	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT693749	hsa-miR-1229-3p	HITS-CLIP	23313552
MIRT681253	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT681252	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT681251	hsa-miR-4257	HITS-CLIP	23706177
MIRT681250	hsa-miR-6746-5p	HITS-CLIP	23706177
MIRT681249	hsa-miR-4680-5p	HITS-CLIP	23706177
MIRT681248	hsa-miR-4537	HITS-CLIP	23706177
MIRT681247	hsa-miR-1827	HITS-CLIP	23706177
MIRT681246	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT681245	hsa-miR-6086	HITS-CLIP	23706177
MIRT681244	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT681243	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681242	hsa-miR-3612	HITS-CLIP	23706177
MIRT681241	hsa-miR-650	HITS-CLIP	23706177
MIRT681240	hsa-miR-6771-5p	HITS-CLIP	23706177
MIRT681239	hsa-miR-7158-3p	HITS-CLIP	23706177
MIRT681238	hsa-miR-203b-3p	HITS-CLIP	23706177
MIRT681237	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT681236	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT637374	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT637374	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT631630	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT631629	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT631628	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT615719	hsa-miR-3137	HITS-CLIP	23824327
MIRT615718	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT615717	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT615716	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT615715	hsa-miR-4775	HITS-CLIP	23824327
MIRT615714	hsa-miR-3686	HITS-CLIP	23824327
MIRT615713	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615712	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT544550	hsa-miR-3163	PAR-CLIP	21572407
MIRT544551	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT544549	hsa-miR-5692b	PAR-CLIP	21572407
MIRT544548	hsa-miR-5692c	PAR-CLIP	21572407
MIRT544547	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT544546	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT544550	hsa-miR-3163	PAR-CLIP	21572407
MIRT544551	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT544549	hsa-miR-5692b	PAR-CLIP	21572407
MIRT544548	hsa-miR-5692c	PAR-CLIP	21572407
MIRT544547	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT544546	hsa-miR-374b-5p	PAR-CLIP	21572407

Gene ontology (GO) Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0031965	Component	Nuclear membrane	IDA
GO:0031965	Component	Nuclear membrane	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 619499
• HGNC: 18609
• e!Ensembl: ENSG00000188283

Protein

• UniProt ID: Q8NA42
• Protein name: Zinc finger protein 383
• Protein function: May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	366 → 388	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	310 → 332	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	170 → 192	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	254 → 276	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	394 → 416	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	282 → 304	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	338 → 360	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	450 → 472	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	226 → 248	Zinc finger, C2H2 type	Domain
  PF01352	KRAB	5 → 46	KRAB box	Family
  PF13465	zf-H2C2_2	436 → 461		Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in heart, placenta, liver, pancreas and with a higher level in skeletal muscle. {ECO:0000269|PubMed:15964543}.
• Sequence:

  MAEGSVMFSDVSIDFSQEEWDCLDPVQRDLYRDVMLENYGNLVSMGLYTPKPQVISLLEQ
  GKEPWMVGRELTRGLCSDLESMCETKLLSLKKEVYEIELCQREIMGLTKHGLEYSSFGDV
  LEYRSHLAKQLGYPNGHFSQEIFTPEYMPTFIQQTFLTLHQIINNEDRPYECKKCGKAFS
  QNSQFIQHQRIHIGEKSYECKECGKFFSCGSHVTRHLKIHTGEKPFECKECGKAFSCSSY
  LSQHQRIHTGKKPYECKECGKAFSYCSNLIDHQRIHTGEKPYECKVCGKAFTKSSQLFQH
  ARIHTGEKPYECKECGKAFTQSSKLVQHQRIHTGEKPYECKECGKAFSSGSALTNHQRIH
  TGEKPYDCKECGKAFTQSSQLRQHQRIHAGEKPFECLECGKAFTQNSQLFQHQRIHTDEK
  PYECNECGKAFNKCSNLTRHLRIHTGEKPYNCKECGKAFSSGSDLIRHQGIHTNK

• Sequence length: 475

Pathways

Reactome Pathway:

Generic Transcription Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★☆☆☆☆ Found in Text Mining only
Otosclerosis	Otosclerosis	GWASDB_DG	19230858		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for ZNF383.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZNF383.