ZNF382 (zinc finger protein 382)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 84911
• Gene name: Zinc finger protein 382
• Gene symbol: ZNF382
• Synonyms (NCBI Gene): KS1
• Chromosome: 19
• Chromosome location: 19q13.12
• Summary: This gene encodes a KRAB domain zinc finger transcription factor (KZNF). KZNFs play critical roles in the regulation of many cellular processes including differentiation, proliferation and apoptosis. The encoded protein inhibits activating protein 1 (AP-1

miRNA Show/Hide all (64)

miRTarBase ID	miRNA	Experiments	Reference
MIRT626566	hsa-miR-4438	HITS-CLIP	23313552
MIRT626565	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT626564	hsa-miR-5095	HITS-CLIP	23313552
MIRT626563	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT626562	hsa-miR-4455	HITS-CLIP	23313552
MIRT626561	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT626566	hsa-miR-4438	HITS-CLIP	23824327
MIRT626565	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT626564	hsa-miR-5095	HITS-CLIP	23824327
MIRT626563	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT626562	hsa-miR-4455	HITS-CLIP	23824327
MIRT626561	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT626566	hsa-miR-4438	HITS-CLIP	23824327
MIRT626565	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT626564	hsa-miR-5095	HITS-CLIP	23824327
MIRT626563	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT626562	hsa-miR-4455	HITS-CLIP	23824327
MIRT626561	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT626566	hsa-miR-4438	HITS-CLIP	23313552
MIRT626565	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT626564	hsa-miR-5095	HITS-CLIP	23313552
MIRT626563	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT626562	hsa-miR-4455	HITS-CLIP	23313552
MIRT626561	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT626566	hsa-miR-4438	HITS-CLIP	23824327
MIRT626565	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT626564	hsa-miR-5095	HITS-CLIP	23824327
MIRT626563	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT626562	hsa-miR-4455	HITS-CLIP	23824327
MIRT626561	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT626566	hsa-miR-4438	HITS-CLIP	23824327
MIRT626565	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT626564	hsa-miR-5095	HITS-CLIP	23824327
MIRT626563	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT626562	hsa-miR-4455	HITS-CLIP	23824327
MIRT626561	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT1523482	hsa-miR-2117	CLIP-seq
MIRT1523483	hsa-miR-3143	CLIP-seq
MIRT1523484	hsa-miR-4273	CLIP-seq
MIRT1523485	hsa-miR-4330	CLIP-seq
MIRT1523486	hsa-miR-4446-5p	CLIP-seq
MIRT1523487	hsa-miR-4755-5p	CLIP-seq
MIRT1523488	hsa-miR-4795-3p	CLIP-seq
MIRT1523489	hsa-miR-543	CLIP-seq
MIRT1523490	hsa-miR-567	CLIP-seq
MIRT1523491	hsa-miR-670	CLIP-seq
MIRT2158185	hsa-miR-4436b-5p	CLIP-seq
MIRT2158186	hsa-miR-483-3p	CLIP-seq
MIRT2377760	hsa-miR-151-3p	CLIP-seq
MIRT2377761	hsa-miR-3064-3p	CLIP-seq
MIRT1523483	hsa-miR-3143	CLIP-seq
MIRT2158185	hsa-miR-4436b-5p	CLIP-seq
MIRT1523486	hsa-miR-4446-5p	CLIP-seq
MIRT1523487	hsa-miR-4755-5p	CLIP-seq
MIRT2377762	hsa-miR-4798-3p	CLIP-seq
MIRT2158186	hsa-miR-483-3p	CLIP-seq
MIRT1523489	hsa-miR-543	CLIP-seq
MIRT2464221	hsa-miR-297	CLIP-seq
MIRT2464222	hsa-miR-3148	CLIP-seq
MIRT2464223	hsa-miR-3688-3p	CLIP-seq
MIRT2464224	hsa-miR-4666-5p	CLIP-seq
MIRT2464225	hsa-miR-4694-3p	CLIP-seq
MIRT2464226	hsa-miR-539	CLIP-seq
MIRT1523490	hsa-miR-567	CLIP-seq

Gene ontology (GO) Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 609516
• HGNC: 17409
• e!Ensembl: ENSG00000161298

Protein

• UniProt ID: Q96SR6
• Protein name: Zinc finger protein 382 (KRAB/zinc finger suppressor protein 1) (KS1) (Multiple zinc finger and krueppel-associated box protein KS1)
• Protein function: Functions as a sequence-specific transcriptional repressor.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	494 → 514	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	408 → 430	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	436 → 458	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	324 → 346	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	380 → 402	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	296 → 318	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	352 → 374	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	464 → 486	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	520 → 542	Zinc finger, C2H2 type	Domain
  PF01352	KRAB	6 → 47	KRAB box	Family

• Tissue specificity: TISSUE SPECIFICITY: Specifically expressed in heart with a weaker expression also detected in skeletal muscle. {ECO:0000269|PubMed:12459182}.
• Sequence:

  MPLQGSVSFKDVTVDFTQEEWQQLDPAQKALYRDVMLENYCHFVSVGFHMAKPDMIRKLE
  QGEELWTQRIFPSYSYLEEDGKTEDVLVKFKEYQDRHSRPLIFINHKKLIKERSNIYGKT
  FTLGKNRISKTILCEYKPDGKVLKNISELVIRNISPIKEKFGDSTGWEKSLLNTKHEKIH
  PAVNLHKQTERVLSGKQELIQHQKVQAPEQPFDHNECEKSFLMKGMLFTHTRAHRGERTF
  EYNKDGIAFIEKSSLSVHPSNLMEKKPSAYNKYGKFLCRKPVFIMPQRPQTEEKPFHCPY
  CGNNFRRKSYLIEHQRIHTGEKPYVCNQCGKAFRQKTALTLHEKTHIEGKPFICIDCGKS
  FRQKATLTRHHKTHTGEKAYECPQCGSAFRKKSYLIDHQRTHTGEKPYQCNECGKAFIQK
  TTLTVHQRTHTGEKPYICNECGKSFCQKTTLTLHQRIHTGEKPYICNECGKSFRQKAILT
  VHHRIHTGEKSNGCPQCGKAFSRKSNLIRHQKTHTGEKPYECKQCGKFFSCKSNLIVHQK
  THKVETTGIQ

• Sequence length: 550

Pathways

Reactome Pathway:

Generic Transcription Pathway

Related Genes

No strongly related genes found yet for ZNF382.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZNF382.