ZNF354C (zinc finger protein 354C)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 30832
• Gene name: Zinc finger protein 354C
• Gene symbol: ZNF354C
• Synonyms (NCBI Gene): KID3
• Chromosome: 5
• Chromosome location: 5q35.3

miRNA Show/Hide all (34)

miRTarBase ID	miRNA	Experiments	Reference
MIRT450085	hsa-miR-548l	PAR-CLIP	22100165
MIRT450084	hsa-miR-495-3p	PAR-CLIP	22100165
MIRT450083	hsa-miR-5688	PAR-CLIP	22100165
MIRT450082	hsa-miR-7-1-3p	PAR-CLIP	22100165
MIRT450081	hsa-miR-7-2-3p	PAR-CLIP	22100165
MIRT450080	hsa-miR-455-5p	PAR-CLIP	22100165
MIRT450079	hsa-miR-3973	PAR-CLIP	22100165
MIRT450078	hsa-miR-4645-3p	PAR-CLIP	22100165
MIRT450077	hsa-miR-636	PAR-CLIP	22100165
MIRT450076	hsa-miR-1273e	PAR-CLIP	22100165
MIRT450075	hsa-miR-218-5p	PAR-CLIP	22100165
MIRT450085	hsa-miR-548l	PAR-CLIP	22100165
MIRT450084	hsa-miR-495-3p	PAR-CLIP	22100165
MIRT450083	hsa-miR-5688	PAR-CLIP	22100165
MIRT450082	hsa-miR-7-1-3p	PAR-CLIP	22100165
MIRT450081	hsa-miR-7-2-3p	PAR-CLIP	22100165
MIRT450080	hsa-miR-455-5p	PAR-CLIP	22100165
MIRT450079	hsa-miR-3973	PAR-CLIP	22100165
MIRT450078	hsa-miR-4645-3p	PAR-CLIP	22100165
MIRT450077	hsa-miR-636	PAR-CLIP	22100165
MIRT450076	hsa-miR-1273e	PAR-CLIP	22100165
MIRT450075	hsa-miR-218-5p	PAR-CLIP	22100165
MIRT1523080	hsa-miR-4698	CLIP-seq
MIRT1523081	hsa-miR-4712-3p	CLIP-seq
MIRT2158028	hsa-miR-4477a	CLIP-seq
MIRT2377606	hsa-miR-1253	CLIP-seq
MIRT2377607	hsa-miR-204	CLIP-seq
MIRT2377608	hsa-miR-211	CLIP-seq
MIRT2377609	hsa-miR-2355-5p	CLIP-seq
MIRT2377610	hsa-miR-3938	CLIP-seq
MIRT2377611	hsa-miR-4755-5p	CLIP-seq
MIRT2377612	hsa-miR-623	CLIP-seq
MIRT2464218	hsa-miR-4272	CLIP-seq
MIRT1523080	hsa-miR-4698	CLIP-seq

Gene ontology (GO) Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP	33154469
GO:0001525	Process	Angiogenesis	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	33154469
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	33154469
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	33154469
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010558	Process	Negative regulation of macromolecule biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0022603	Process	Regulation of anatomical structure morphogenesis	IEA
GO:0031965	Component	Nuclear membrane	IDA	33154469
GO:0031965	Component	Nuclear membrane	IEA
GO:0031981	Component	Nuclear lumen	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1903671	Process	Negative regulation of sprouting angiogenesis	IMP	33154469

Other IDs

• MIM: 619511
• HGNC: 16736
• e!Ensembl: ENSG00000177932

Protein

• UniProt ID: Q86Y25
• Protein name: Zinc finger protein 354C (Kidney, ischemia, and developmentally-regulated protein 3) (hKID3)
• Protein function: Transcriptional repressor that inhibits endothelial angiogenic sprouting (PubMed:15555547, PubMed:33154469). Suppresses osteogenic effects of RUNX2 and may be involved in osteoblastic differentiation (By similarity). Plays a role in postnatal my
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	272 → 294	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	300 → 322	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	244 → 266	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	216 → 238	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	468 → 490	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	384 → 406	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	496 → 518	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	440 → 462	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	412 → 434	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	356 → 378	Zinc finger, C2H2 type	Domain
  PF01352	KRAB	11 → 52	KRAB box	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in kidney and skeletal muscle. Very low expression in brain and heart (PubMed:15555547). Strongly expressed in vascular cells such as umbilical vein endothelial cells, microvascular endothelial cells and aortic smooth muscle
• Sequence:

  MAVDLLSAQEPVTFRDVAVFFSQDEWLHLDSAQRALYREVMLENYSSLVSLGIPFSMPKL
  IHQLQQGEDPCMVEREVPSDTRLGFKTWLETEALPHRQDIFIEETSQGMVKKESIKDGHW
  DINFEEAVEFESEIEEEQEKKPLRQMIDSHEKTISEDGNHTSLELGKSLFTNTALVTQQS
  VPIERIPNMYYTFGKDFKQNFDLMKCFQIYPGGKPHICNECGKSFKQNLHLIEHQRIHTG
  EKPYKCNECEKTFSHRSSLLSHQRIHTGEKPYKCNECEKAFSNSSTLIKHLRVHTGEKPY
  RCRECGKAFSQCSTLTVHQRIHTGEKLYKCGECEKAFNCRAKLHRHQRIHTGEKPYKCSE
  CGKGYSQFTSLAEHQRFHTGEQLYTCLECGRTFTRIVTLIEHQRIHTGQKPYQCNECEKA
  FNQYSSFNEHRKIHTGEKLYTCEECGKAFGCKSNLYRHQRIHTGEKPYQCNQCGKAFSQY
  SFLTEHERIHTGEKLYKCMECGKAYSYRSNLCRHKKVHTKEKLYKWKEYGKPFICSSSLT
  QYQRFFKGDKAYEV

• Sequence length: 554

Pathways

Reactome Pathway:

Generic Transcription Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
BIPOLAR DISORDER	—	GWAS catalog	34099189	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	34099189	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	34099189	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Neoplasms	Breast neoplasm	Pubtator	27809618	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	27458175	Associate	★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	27723809		★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	27723809		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for ZNF354C.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZNF354C.