ZNF226 (zinc finger protein 226)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 7769
• Gene name: Zinc finger protein 226
• Gene symbol: ZNF226
• Synonyms (NCBI Gene): -
• Chromosome: 19
• Chromosome location: 19q13.31

miRNA Show/Hide all (118)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002542	hsa-miR-373-3p	Microarray	15685193
MIRT024789	hsa-miR-215-5p	Microarray	19074876
MIRT026695	hsa-miR-192-5p	Microarray	19074876
MIRT042058	hsa-miR-484	CLASH	23622248
MIRT612279	hsa-miR-8485	HITS-CLIP	23313552
MIRT628986	hsa-miR-4643	HITS-CLIP	23313552
MIRT612280	hsa-miR-4311	HITS-CLIP	23824327
MIRT612279	hsa-miR-8485	HITS-CLIP	23824327
MIRT612280	hsa-miR-4311	HITS-CLIP	23824327
MIRT612279	hsa-miR-8485	HITS-CLIP	23824327
MIRT612278	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612280	hsa-miR-4311	HITS-CLIP	23824327
MIRT612279	hsa-miR-8485	HITS-CLIP	23824327
MIRT612278	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612279	hsa-miR-8485	HITS-CLIP	23824327
MIRT628986	hsa-miR-4643	HITS-CLIP	23824327
MIRT612280	hsa-miR-4311	HITS-CLIP	23824327
MIRT612279	hsa-miR-8485	HITS-CLIP	23824327
MIRT612278	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612280	hsa-miR-4311	HITS-CLIP	23824327
MIRT612279	hsa-miR-8485	HITS-CLIP	23824327
MIRT612278	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT505049	hsa-miR-188-5p	PAR-CLIP	20371350
MIRT505048	hsa-miR-6866-3p	PAR-CLIP	20371350
MIRT505047	hsa-miR-4728-3p	PAR-CLIP	20371350
MIRT505046	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT505045	hsa-miR-8075	PAR-CLIP	20371350
MIRT505043	hsa-miR-491-3p	PAR-CLIP	20371350
MIRT505041	hsa-miR-507	PAR-CLIP	20371350
MIRT505040	hsa-miR-557	PAR-CLIP	20371350
MIRT505039	hsa-miR-3680-3p	PAR-CLIP	20371350
MIRT519799	hsa-miR-4524b-3p	PAR-CLIP	23446348
MIRT519795	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT519798	hsa-miR-29a-5p	PAR-CLIP	23446348
MIRT519797	hsa-miR-4524a-3p	PAR-CLIP	23446348
MIRT519796	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT519795	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT519794	hsa-miR-3149	PAR-CLIP	23446348
MIRT519793	hsa-miR-129-5p	PAR-CLIP	23446348
MIRT505049	hsa-miR-188-5p	PAR-CLIP	23446348
MIRT505048	hsa-miR-6866-3p	PAR-CLIP	23446348
MIRT505047	hsa-miR-4728-3p	PAR-CLIP	23446348
MIRT505045	hsa-miR-8075	PAR-CLIP	23446348
MIRT505044	hsa-miR-106a-3p	PAR-CLIP	23446348
MIRT505043	hsa-miR-491-3p	PAR-CLIP	23446348
MIRT505042	hsa-miR-450b-5p	PAR-CLIP	23446348
MIRT505041	hsa-miR-507	PAR-CLIP	23446348
MIRT505040	hsa-miR-557	PAR-CLIP	23446348
MIRT505039	hsa-miR-3680-3p	PAR-CLIP	23446348
MIRT505049	hsa-miR-188-5p	PAR-CLIP	23446348
MIRT505048	hsa-miR-6866-3p	PAR-CLIP	23446348
MIRT505047	hsa-miR-4728-3p	PAR-CLIP	23446348
MIRT505046	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT505045	hsa-miR-8075	PAR-CLIP	23446348
MIRT505044	hsa-miR-106a-3p	PAR-CLIP	23446348
MIRT505043	hsa-miR-491-3p	PAR-CLIP	23446348
MIRT505042	hsa-miR-450b-5p	PAR-CLIP	23446348
MIRT505041	hsa-miR-507	PAR-CLIP	23446348
MIRT505040	hsa-miR-557	PAR-CLIP	23446348
MIRT505039	hsa-miR-3680-3p	PAR-CLIP	23446348
MIRT612279	hsa-miR-8485	HITS-CLIP	23313552
MIRT628986	hsa-miR-4643	HITS-CLIP	23313552
MIRT612280	hsa-miR-4311	HITS-CLIP	23824327
MIRT612279	hsa-miR-8485	HITS-CLIP	23824327
MIRT612280	hsa-miR-4311	HITS-CLIP	23824327
MIRT612279	hsa-miR-8485	HITS-CLIP	23824327
MIRT612278	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612280	hsa-miR-4311	HITS-CLIP	23824327
MIRT612279	hsa-miR-8485	HITS-CLIP	23824327
MIRT612278	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612279	hsa-miR-8485	HITS-CLIP	23824327
MIRT628986	hsa-miR-4643	HITS-CLIP	23824327
MIRT612280	hsa-miR-4311	HITS-CLIP	23824327
MIRT612279	hsa-miR-8485	HITS-CLIP	23824327
MIRT612278	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612280	hsa-miR-4311	HITS-CLIP	23824327
MIRT612279	hsa-miR-8485	HITS-CLIP	23824327
MIRT612278	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT505049	hsa-miR-188-5p	PAR-CLIP	20371350
MIRT505048	hsa-miR-6866-3p	PAR-CLIP	20371350
MIRT505047	hsa-miR-4728-3p	PAR-CLIP	20371350
MIRT505046	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT505045	hsa-miR-8075	PAR-CLIP	20371350
MIRT505043	hsa-miR-491-3p	PAR-CLIP	20371350
MIRT505041	hsa-miR-507	PAR-CLIP	20371350
MIRT505040	hsa-miR-557	PAR-CLIP	20371350
MIRT505039	hsa-miR-3680-3p	PAR-CLIP	20371350
MIRT519799	hsa-miR-4524b-3p	PAR-CLIP	23446348
MIRT519795	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT519798	hsa-miR-29a-5p	PAR-CLIP	23446348
MIRT519797	hsa-miR-4524a-3p	PAR-CLIP	23446348
MIRT519796	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT519795	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT519794	hsa-miR-3149	PAR-CLIP	23446348
MIRT519793	hsa-miR-129-5p	PAR-CLIP	23446348
MIRT505049	hsa-miR-188-5p	PAR-CLIP	23446348
MIRT505048	hsa-miR-6866-3p	PAR-CLIP	23446348
MIRT505047	hsa-miR-4728-3p	PAR-CLIP	23446348
MIRT505045	hsa-miR-8075	PAR-CLIP	23446348
MIRT505044	hsa-miR-106a-3p	PAR-CLIP	23446348
MIRT505043	hsa-miR-491-3p	PAR-CLIP	23446348
MIRT505042	hsa-miR-450b-5p	PAR-CLIP	23446348
MIRT505041	hsa-miR-507	PAR-CLIP	23446348
MIRT505040	hsa-miR-557	PAR-CLIP	23446348
MIRT505039	hsa-miR-3680-3p	PAR-CLIP	23446348
MIRT505049	hsa-miR-188-5p	PAR-CLIP	23446348
MIRT505048	hsa-miR-6866-3p	PAR-CLIP	23446348
MIRT505047	hsa-miR-4728-3p	PAR-CLIP	23446348
MIRT505046	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT505045	hsa-miR-8075	PAR-CLIP	23446348
MIRT505044	hsa-miR-106a-3p	PAR-CLIP	23446348
MIRT505043	hsa-miR-491-3p	PAR-CLIP	23446348
MIRT505042	hsa-miR-450b-5p	PAR-CLIP	23446348
MIRT505041	hsa-miR-507	PAR-CLIP	23446348
MIRT505040	hsa-miR-557	PAR-CLIP	23446348
MIRT505039	hsa-miR-3680-3p	PAR-CLIP	23446348
MIRT2668523	hsa-miR-4799-5p	CLIP-seq
MIRT2668524	hsa-miR-513a-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9NYT6
• Protein name: Zinc finger protein 226
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	727 → 749	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	391 → 413	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	615 → 637	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	363 → 385	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	643 → 665	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	447 → 469	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	503 → 525	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	531 → 553	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	475 → 497	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	699 → 721	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	755 → 777	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	587 → 609	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	307 → 329	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	335 → 357	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	559 → 581	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	419 → 441	Zinc finger, C2H2 type	Domain
  PF01352	KRAB	7 → 48	KRAB box	Family

• Sequence:

  MNMFKEAVTFKDVAVAFTEEELGLLGPAQRKLYRDVMVENFRNLLSVGHPPFKQDVSPIE
  RNEQLWIMTTATRRQGNLGEKNQSKLITVQDRESEEELSCWQIWQQIANDLTRCQDSMIN
  NSQCHKQGDFPYQVGTELSIQISEDENYIVNKADGPNNTGNPEFPILRTQDSWRKTFLTE
  SQRLNRDQQISIKNKLCQCKKGVDPIGWISHHDGHRVHKSEKSYRPNDYEKDNMKILTFD
  HNSMIHTGQKSYQCNECKKPFSDLSSFDLHQQLQSGEKSLTCVERGKGFCYSPVLPVHQK
  VHVGEKLKCDECGKEFSQGAHLQTHQKVHVIEKPYKCKQCGKGFSRRSALNVHCKVHTAE
  KPYNCEECGRAFSQASHLQDHQRLHTGEKPFKCDACGKSFSRNSHLQSHQRVHTGEKPYK
  CEECGKGFICSSNLYIHQRVHTGEKPYKCEECGKGFSRPSSLQAHQGVHTGEKSYICTVC
  GKGFTLSSNLQAHQRVHTGEKPYKCNECGKSFRRNSHYQVHLVVHTGEKPYKCEICGKGF
  SQSSYLQIHQKAHSIEKPFKCEECGQGFNQSSRLQIHQLIHTGEKPYKCEECGKGFSRRA
  DLKIHCRIHTGEKPYNCEECGKVFRQASNLLAHQRVHSGEKPFKCEECGKSFGRSAHLQA
  HQKVHTGDKPYKCDECGKGFKWSLNLDMHQRVHTGEKPYKCGECGKYFSQASSLQLHQSV
  HTGEKPYKCDVCGKVFSRSSQLQSHQRVHTGEKPYKCEICGKSFSWRSNLTVHHRIHVGD
  KSYKSNRGGKNIRESTQEKKSIK

• Sequence length: 803

Pathways

Reactome Pathway:

Generic Transcription Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (6)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Colorectal cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

No strongly related genes found yet for ZNF226.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZNF226.