ZNF215 (zinc finger protein 215)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 7762
• Gene name: Zinc finger protein 215
• Gene symbol: ZNF215
• Synonyms (NCBI Gene): BAZ-2, BAZ2, ZKSCAN11, ZSCAN43
• Chromosome: 11
• Chromosome location: 11p15.4
• Summary: This gene is imprinted in a tissue-specific manner with preferential expression in the testis, and encodes a zinc finger protein that belongs to a family of zinc finger transcription factors. The encoded protein contains an N-terminal SRE-ZBP, Ctfin51, AW

miRNA Show/Hide all (83)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024381	hsa-miR-215-5p	Microarray	19074876
MIRT026389	hsa-miR-192-5p	Microarray	19074876
MIRT054587	hsa-miR-100-5p	qRT-PCR, Western blot	23778488
MIRT563137	hsa-miR-4302	PAR-CLIP	20371350
MIRT563136	hsa-miR-1825	PAR-CLIP	20371350
MIRT563135	hsa-miR-199a-5p	PAR-CLIP	20371350
MIRT563134	hsa-miR-199b-5p	PAR-CLIP	20371350
MIRT563133	hsa-miR-766-3p	PAR-CLIP	20371350
MIRT563132	hsa-miR-3925-3p	PAR-CLIP	20371350
MIRT563131	hsa-miR-1-3p	PAR-CLIP	20371350
MIRT563130	hsa-miR-206	PAR-CLIP	20371350
MIRT563129	hsa-miR-613	PAR-CLIP	20371350
MIRT563128	hsa-miR-1257	PAR-CLIP	20371350
MIRT563127	hsa-miR-450a-2-3p	PAR-CLIP	20371350
MIRT563126	hsa-miR-4260	PAR-CLIP	20371350
MIRT563125	hsa-miR-5572	PAR-CLIP	20371350
MIRT563124	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT563137	hsa-miR-4302	PAR-CLIP	20371350
MIRT563136	hsa-miR-1825	PAR-CLIP	20371350
MIRT563135	hsa-miR-199a-5p	PAR-CLIP	20371350
MIRT563134	hsa-miR-199b-5p	PAR-CLIP	20371350
MIRT563133	hsa-miR-766-3p	PAR-CLIP	20371350
MIRT563132	hsa-miR-3925-3p	PAR-CLIP	20371350
MIRT563131	hsa-miR-1-3p	PAR-CLIP	20371350
MIRT563130	hsa-miR-206	PAR-CLIP	20371350
MIRT563129	hsa-miR-613	PAR-CLIP	20371350
MIRT563128	hsa-miR-1257	PAR-CLIP	20371350
MIRT563127	hsa-miR-450a-2-3p	PAR-CLIP	20371350
MIRT563126	hsa-miR-4260	PAR-CLIP	20371350
MIRT563125	hsa-miR-5572	PAR-CLIP	20371350
MIRT563124	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT563137	hsa-miR-4302	PAR-CLIP	20371350
MIRT563136	hsa-miR-1825	PAR-CLIP	20371350
MIRT563135	hsa-miR-199a-5p	PAR-CLIP	20371350
MIRT563134	hsa-miR-199b-5p	PAR-CLIP	20371350
MIRT563133	hsa-miR-766-3p	PAR-CLIP	20371350
MIRT563132	hsa-miR-3925-3p	PAR-CLIP	20371350
MIRT563131	hsa-miR-1-3p	PAR-CLIP	20371350
MIRT563130	hsa-miR-206	PAR-CLIP	20371350
MIRT563129	hsa-miR-613	PAR-CLIP	20371350
MIRT563128	hsa-miR-1257	PAR-CLIP	20371350
MIRT563127	hsa-miR-450a-2-3p	PAR-CLIP	20371350
MIRT563126	hsa-miR-4260	PAR-CLIP	20371350
MIRT563125	hsa-miR-5572	PAR-CLIP	20371350
MIRT563124	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT563137	hsa-miR-4302	PAR-CLIP	20371350
MIRT563136	hsa-miR-1825	PAR-CLIP	20371350
MIRT563135	hsa-miR-199a-5p	PAR-CLIP	20371350
MIRT563134	hsa-miR-199b-5p	PAR-CLIP	20371350
MIRT563133	hsa-miR-766-3p	PAR-CLIP	20371350
MIRT563132	hsa-miR-3925-3p	PAR-CLIP	20371350
MIRT563131	hsa-miR-1-3p	PAR-CLIP	20371350
MIRT563130	hsa-miR-206	PAR-CLIP	20371350
MIRT563129	hsa-miR-613	PAR-CLIP	20371350
MIRT563128	hsa-miR-1257	PAR-CLIP	20371350
MIRT563127	hsa-miR-450a-2-3p	PAR-CLIP	20371350
MIRT563126	hsa-miR-4260	PAR-CLIP	20371350
MIRT563125	hsa-miR-5572	PAR-CLIP	20371350
MIRT563124	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT1518157	hsa-miR-1200	CLIP-seq
MIRT1518158	hsa-miR-4324	CLIP-seq
MIRT1518159	hsa-miR-450b-3p	CLIP-seq
MIRT1518160	hsa-miR-4713-3p	CLIP-seq
MIRT1518161	hsa-miR-544b	CLIP-seq
MIRT1518162	hsa-miR-548b-3p	CLIP-seq
MIRT1518163	hsa-miR-638	CLIP-seq
MIRT1518164	hsa-miR-769-3p	CLIP-seq
MIRT2375980	hsa-miR-1292	CLIP-seq
MIRT2375981	hsa-miR-297	CLIP-seq
MIRT2375982	hsa-miR-3120-3p	CLIP-seq
MIRT2375983	hsa-miR-3149	CLIP-seq
MIRT2375984	hsa-miR-3653	CLIP-seq
MIRT2375985	hsa-miR-3658	CLIP-seq
MIRT2375986	hsa-miR-4318	CLIP-seq
MIRT2375987	hsa-miR-4471	CLIP-seq
MIRT2375988	hsa-miR-4652-3p	CLIP-seq
MIRT2375989	hsa-miR-4693-5p	CLIP-seq
MIRT2375990	hsa-miR-4753-3p	CLIP-seq
MIRT2375991	hsa-miR-495	CLIP-seq
MIRT2375992	hsa-miR-541	CLIP-seq
MIRT2375993	hsa-miR-630	CLIP-seq
MIRT2375994	hsa-miR-654-5p	CLIP-seq
MIRT2375995	hsa-miR-892a	CLIP-seq

Gene ontology (GO) Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	NAS	10762538
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010558	Process	Negative regulation of macromolecule biosynthetic process	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 605016
• HGNC: 13007
• e!Ensembl: ENSG00000149054

Protein

• UniProt ID: Q9UL58
• Protein name: Zinc finger protein 215 (BWSCR2-associated zinc finger protein 2) (BAZ-2) (Zinc finger protein with KRAB and SCAN domains 11)
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	462 → 484	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	490 → 512	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	407 → 429	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	379 → 401	Zinc finger, C2H2 type	Domain
  PF01352	KRAB	163 → 203	KRAB box	Family
  PF02023	SCAN	44 → 133	SCAN domain	Domain

• Sequence:

  MQPLSKLMAISKPRNLSLREQREVLRADMSWQQETNPVVETHDSEASRQKFRHFQYLKVS
  GPHEALSQLWELCLQWLRPEIHTKKQIIELLVLEQFLAILPEEVRTWVNLQHPNNSKDMV
  TLIEDVIEMLEDEDMPCKDSALQMGSIKEKMKAGSRTGKPQEPVTFKDVVVEFSKEEWGQ
  LDSAVKNLYRNVMLENFRNLNSLRKAHLLSKPFESLKLESKKKRWIMEKEIPRKTIFDMK
  SISGEESSHGVIMTRLTESGHPSSDAWKGENWLYRNQKKWDINLPQEAFIPETIYTEEED
  FECSENKKSFDINSVSSICAIQVGIPSRKGSPKCDKFKTYFKFNLDSVGKQHSEYEYGND
  LSLSTDIRHQKSHTTMNSYECYQCGKAFCRSSSLIRHQIIHTGEKPYKCSECGRFFNRRT
  NLTKHQKLHAEAKACTSNKCGKAFSKSEDSNNPTLHFGNNFYQCVNCGKSFNRSSSLIRH
  QMIHTGEKPFKCKECSKAFNRSSNLVKHQKLHTRDKS

• Sequence length: 517

Pathways

Reactome Pathway:

Generic Transcription Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
BECKWITH-WIEDEMANN SYNDROME	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE ASTHMA	—	GWAS catalog	40465716	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POST-OPERATIVE ACUTE KIDNEY INJURY	—	GWAS catalog	37124606	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (7)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Beckwith-Wiedemann Syndrome	Beckwith-Wiedemann Syndrome	BEFREE	10762538		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cryptorchidism	Cryptorchidism	BEFREE	12970396, 20980787		★☆☆☆☆ Found in Text Mining only
Cryptorchidism	Cryptorchidism	Pubtator	23025704	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	27402879		★☆☆☆☆ Found in Text Mining only
Oligospermia	Oligospermia	BEFREE	12970396		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	37574751	Associate	★☆☆☆☆ Found in Text Mining only
Subfertility	Subfertility	BEFREE	12970396		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for ZNF215.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZNF215.