ZNF195 (zinc finger protein 195)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Diseases linked via similar genes

Gene

• Entrez ID: 7748
• Gene name: Zinc finger protein 195
• Gene symbol: ZNF195
• Synonyms (NCBI Gene): HRF1, ZNFP104
• Chromosome: 11
• Chromosome location: 11p15.4
• Summary: This gene encodes a protein belonging to the Krueppel C2H2-type zinc-finger protein family. These family members are transcription factors that are implicated in a variety of cellular processes. This gene is located near the centromeric border of chromoso

miRNA Show/Hide all (185)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029601	hsa-miR-26b-5p	Microarray	19088304
MIRT683705	hsa-miR-412-3p	HITS-CLIP	23313552
MIRT683704	hsa-miR-6754-3p	HITS-CLIP	23313552
MIRT683703	hsa-miR-6837-3p	HITS-CLIP	23313552
MIRT683702	hsa-miR-377-3p	HITS-CLIP	23313552
MIRT643504	hsa-miR-622	HITS-CLIP	23824327
MIRT643503	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT643502	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT643501	hsa-miR-5193	HITS-CLIP	23824327
MIRT643500	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT404855	hsa-miR-4264	HITS-CLIP	23824327
MIRT643499	hsa-miR-6870-3p	HITS-CLIP	23824327
MIRT560087	hsa-miR-5571-5p	PAR-CLIP	20371350
MIRT560086	hsa-miR-218-2-3p	PAR-CLIP	20371350
MIRT560085	hsa-miR-758-5p	PAR-CLIP	20371350
MIRT560084	hsa-miR-1226-3p	PAR-CLIP	20371350
MIRT560083	hsa-miR-4733-3p	PAR-CLIP	20371350
MIRT560079	hsa-miR-6511a-3p	PAR-CLIP	20371350
MIRT560078	hsa-miR-6511b-3p	PAR-CLIP	20371350
MIRT560077	hsa-miR-6784-3p	PAR-CLIP	20371350
MIRT560076	hsa-miR-6862-3p	PAR-CLIP	20371350
MIRT560074	hsa-miR-584-5p	PAR-CLIP	20371350
MIRT560072	hsa-miR-1229-3p	PAR-CLIP	20371350
MIRT560073	hsa-miR-4753-3p	PAR-CLIP	20371350
MIRT560071	hsa-miR-4452	PAR-CLIP	20371350
MIRT560070	hsa-miR-29b-2-5p	PAR-CLIP	20371350
MIRT560087	hsa-miR-5571-5p	PAR-CLIP	20371350
MIRT560086	hsa-miR-218-2-3p	PAR-CLIP	20371350
MIRT560085	hsa-miR-758-5p	PAR-CLIP	20371350
MIRT560084	hsa-miR-1226-3p	PAR-CLIP	20371350
MIRT560083	hsa-miR-4733-3p	PAR-CLIP	20371350
MIRT560082	hsa-miR-4302	PAR-CLIP	20371350
MIRT560081	hsa-miR-199a-5p	PAR-CLIP	20371350
MIRT560080	hsa-miR-199b-5p	PAR-CLIP	20371350
MIRT560079	hsa-miR-6511a-3p	PAR-CLIP	20371350
MIRT560078	hsa-miR-6511b-3p	PAR-CLIP	20371350
MIRT560077	hsa-miR-6784-3p	PAR-CLIP	20371350
MIRT560076	hsa-miR-6862-3p	PAR-CLIP	20371350
MIRT560075	hsa-miR-1257	PAR-CLIP	20371350
MIRT560074	hsa-miR-584-5p	PAR-CLIP	20371350
MIRT560072	hsa-miR-1229-3p	PAR-CLIP	20371350
MIRT560073	hsa-miR-4753-3p	PAR-CLIP	20371350
MIRT560071	hsa-miR-4452	PAR-CLIP	20371350
MIRT560070	hsa-miR-29b-2-5p	PAR-CLIP	20371350
MIRT560069	hsa-miR-675-3p	PAR-CLIP	20371350
MIRT560068	hsa-miR-297	PAR-CLIP	20371350
MIRT560067	hsa-miR-3149	PAR-CLIP	20371350
MIRT683705	hsa-miR-412-3p	HITS-CLIP	23313552
MIRT683704	hsa-miR-6754-3p	HITS-CLIP	23313552
MIRT683703	hsa-miR-6837-3p	HITS-CLIP	23313552
MIRT683702	hsa-miR-377-3p	HITS-CLIP	23313552
MIRT643504	hsa-miR-622	HITS-CLIP	23824327
MIRT643503	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT643502	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT643501	hsa-miR-5193	HITS-CLIP	23824327
MIRT643500	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT404855	hsa-miR-4264	HITS-CLIP	23824327
MIRT643499	hsa-miR-6870-3p	HITS-CLIP	23824327
MIRT560087	hsa-miR-5571-5p	PAR-CLIP	20371350
MIRT560086	hsa-miR-218-2-3p	PAR-CLIP	20371350
MIRT560085	hsa-miR-758-5p	PAR-CLIP	20371350
MIRT560084	hsa-miR-1226-3p	PAR-CLIP	20371350
MIRT560083	hsa-miR-4733-3p	PAR-CLIP	20371350
MIRT560079	hsa-miR-6511a-3p	PAR-CLIP	20371350
MIRT560078	hsa-miR-6511b-3p	PAR-CLIP	20371350
MIRT560077	hsa-miR-6784-3p	PAR-CLIP	20371350
MIRT560076	hsa-miR-6862-3p	PAR-CLIP	20371350
MIRT560074	hsa-miR-584-5p	PAR-CLIP	20371350
MIRT560072	hsa-miR-1229-3p	PAR-CLIP	20371350
MIRT560073	hsa-miR-4753-3p	PAR-CLIP	20371350
MIRT560071	hsa-miR-4452	PAR-CLIP	20371350
MIRT560070	hsa-miR-29b-2-5p	PAR-CLIP	20371350
MIRT560087	hsa-miR-5571-5p	PAR-CLIP	20371350
MIRT560086	hsa-miR-218-2-3p	PAR-CLIP	20371350
MIRT560085	hsa-miR-758-5p	PAR-CLIP	20371350
MIRT560084	hsa-miR-1226-3p	PAR-CLIP	20371350
MIRT560083	hsa-miR-4733-3p	PAR-CLIP	20371350
MIRT560082	hsa-miR-4302	PAR-CLIP	20371350
MIRT560081	hsa-miR-199a-5p	PAR-CLIP	20371350
MIRT560080	hsa-miR-199b-5p	PAR-CLIP	20371350
MIRT560079	hsa-miR-6511a-3p	PAR-CLIP	20371350
MIRT560078	hsa-miR-6511b-3p	PAR-CLIP	20371350
MIRT560077	hsa-miR-6784-3p	PAR-CLIP	20371350
MIRT560076	hsa-miR-6862-3p	PAR-CLIP	20371350
MIRT560075	hsa-miR-1257	PAR-CLIP	20371350
MIRT560074	hsa-miR-584-5p	PAR-CLIP	20371350
MIRT560072	hsa-miR-1229-3p	PAR-CLIP	20371350
MIRT560073	hsa-miR-4753-3p	PAR-CLIP	20371350
MIRT560071	hsa-miR-4452	PAR-CLIP	20371350
MIRT560070	hsa-miR-29b-2-5p	PAR-CLIP	20371350
MIRT560069	hsa-miR-675-3p	PAR-CLIP	20371350
MIRT560068	hsa-miR-297	PAR-CLIP	20371350
MIRT560067	hsa-miR-3149	PAR-CLIP	20371350
MIRT1517565	hsa-miR-186	CLIP-seq
MIRT1517566	hsa-miR-2467-3p	CLIP-seq
MIRT1517567	hsa-miR-3675-3p	CLIP-seq
MIRT1517568	hsa-miR-3678-3p	CLIP-seq
MIRT1517569	hsa-miR-3921	CLIP-seq
MIRT1517570	hsa-miR-3944-5p	CLIP-seq
MIRT1517571	hsa-miR-4457	CLIP-seq
MIRT1517572	hsa-miR-4475	CLIP-seq
MIRT1517573	hsa-miR-4653-5p	CLIP-seq
MIRT1517574	hsa-miR-106a	CLIP-seq
MIRT1517575	hsa-miR-106b	CLIP-seq
MIRT1517576	hsa-miR-17	CLIP-seq
MIRT1517577	hsa-miR-20a	CLIP-seq
MIRT1517578	hsa-miR-20b	CLIP-seq
MIRT1517579	hsa-miR-3152-5p	CLIP-seq
MIRT1517580	hsa-miR-3171	CLIP-seq
MIRT1517581	hsa-miR-337-5p	CLIP-seq
MIRT1517582	hsa-miR-3609	CLIP-seq
MIRT1517583	hsa-miR-383	CLIP-seq
MIRT1517584	hsa-miR-4468	CLIP-seq
MIRT1517585	hsa-miR-4485	CLIP-seq
MIRT1517586	hsa-miR-4495	CLIP-seq
MIRT1517587	hsa-miR-4502	CLIP-seq
MIRT1517588	hsa-miR-4637	CLIP-seq
MIRT1517589	hsa-miR-4654	CLIP-seq
MIRT1517590	hsa-miR-4680-5p	CLIP-seq
MIRT1517591	hsa-miR-4714-5p	CLIP-seq
MIRT1517592	hsa-miR-4725-5p	CLIP-seq
MIRT1517593	hsa-miR-4769-5p	CLIP-seq
MIRT1517594	hsa-miR-4772-5p	CLIP-seq
MIRT1517595	hsa-miR-4774-3p	CLIP-seq
MIRT1517596	hsa-miR-4795-3p	CLIP-seq
MIRT1517597	hsa-miR-4796-3p	CLIP-seq
MIRT1517598	hsa-miR-4799-5p	CLIP-seq
MIRT1517599	hsa-miR-496	CLIP-seq
MIRT1517600	hsa-miR-504	CLIP-seq
MIRT1517601	hsa-miR-519d	CLIP-seq
MIRT1517602	hsa-miR-548ah	CLIP-seq
MIRT1517603	hsa-miR-93	CLIP-seq
MIRT1517566	hsa-miR-2467-3p	CLIP-seq
MIRT1517568	hsa-miR-3678-3p	CLIP-seq
MIRT1517604	hsa-miR-3692	CLIP-seq
MIRT1517570	hsa-miR-3944-5p	CLIP-seq
MIRT1517571	hsa-miR-4457	CLIP-seq
MIRT1517572	hsa-miR-4475	CLIP-seq
MIRT1517605	hsa-miR-4712-3p	CLIP-seq
MIRT1517592	hsa-miR-4725-5p	CLIP-seq
MIRT1517606	hsa-miR-4729	CLIP-seq
MIRT1517596	hsa-miR-4795-3p	CLIP-seq
MIRT1517599	hsa-miR-496	CLIP-seq
MIRT1517600	hsa-miR-504	CLIP-seq
MIRT2375829	hsa-miR-1243	CLIP-seq
MIRT2375830	hsa-miR-1283	CLIP-seq
MIRT2375831	hsa-miR-140-3p	CLIP-seq
MIRT2375832	hsa-miR-3120-5p	CLIP-seq
MIRT2375833	hsa-miR-3130-3p	CLIP-seq
MIRT2375834	hsa-miR-346	CLIP-seq
MIRT2375835	hsa-miR-3654	CLIP-seq
MIRT2375836	hsa-miR-4288	CLIP-seq
MIRT2375837	hsa-miR-4793-3p	CLIP-seq
MIRT2375838	hsa-miR-486-5p	CLIP-seq
MIRT2375839	hsa-miR-632	CLIP-seq
MIRT2375840	hsa-miR-935	CLIP-seq
MIRT2397449	hsa-miR-1275	CLIP-seq
MIRT2397450	hsa-miR-3170	CLIP-seq
MIRT2397451	hsa-miR-342-5p	CLIP-seq
MIRT2397452	hsa-miR-3940-5p	CLIP-seq
MIRT2397453	hsa-miR-4300	CLIP-seq
MIRT2397454	hsa-miR-4447	CLIP-seq
MIRT2397455	hsa-miR-4472	CLIP-seq
MIRT2397456	hsa-miR-4507	CLIP-seq
MIRT2397457	hsa-miR-4525	CLIP-seq
MIRT2397458	hsa-miR-4651	CLIP-seq
MIRT2397459	hsa-miR-4664-5p	CLIP-seq
MIRT2397460	hsa-miR-4665-5p	CLIP-seq
MIRT2397461	hsa-miR-4723-5p	CLIP-seq
MIRT2397462	hsa-miR-608	CLIP-seq
MIRT2397463	hsa-miR-625	CLIP-seq
MIRT2397464	hsa-miR-920	CLIP-seq
MIRT2397465	hsa-miR-939	CLIP-seq
MIRT2668324	hsa-miR-1228	CLIP-seq
MIRT1517565	hsa-miR-186	CLIP-seq
MIRT2668325	hsa-miR-23a	CLIP-seq
MIRT2668326	hsa-miR-23b	CLIP-seq
MIRT2668327	hsa-miR-23c	CLIP-seq
MIRT2668328	hsa-miR-3065-3p	CLIP-seq
MIRT2668329	hsa-miR-3646	CLIP-seq
MIRT1517567	hsa-miR-3675-3p	CLIP-seq
MIRT1517569	hsa-miR-3921	CLIP-seq
MIRT1517573	hsa-miR-4653-5p	CLIP-seq
MIRT2668330	hsa-miR-5096	CLIP-seq
MIRT2668331	hsa-miR-591	CLIP-seq

Gene ontology (GO) Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008270	Function	Zinc ion binding	NAS	9344677
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 602187
• HGNC: 12986
• e!Ensembl: ENSG00000005801

Protein

• UniProt ID: O14628
• Protein name: Zinc finger protein 195
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	522 → 544	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	578 → 600	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	466 → 488	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	438 → 460	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	606 → 628	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	494 → 516	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	244 → 266	Zinc finger, C2H2 type	Domain
  PF01352	KRAB	3 → 44	KRAB box	Family
  PF13912	zf-C2H2_6	550 → 575		Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in adult heart, brain, placenta, skeletal muscle and pancreas, and in fetal lung, kidney and brain. There is little expression in adult lung, liver and kidney.
• Sequence:

  MTLLTFRDVAIEFSLEEWKCLDLAQQNLYRDVMLENYRNLFSVGLTVCKPGLITCLEQRK
  EPWNVKRQEAADGHPEMGFHHATQACLELLGSSDLPASASQSAGITGVNHRAQPGLNVSV
  DKFTALCSPGVLQTVKWFLEFRCIFSLAMSSHFTQDLLPEQGIQDAFPKRILRGYGNCGL
  DNLYLRKDWESLDECKLQKDYNGLNQCSSTTHSKIFQYNKYVKIFDNFSNLHRRNISNTG
  EKPFKCQECGKSFQMLSFLTEHQKIHTGKKFQKCGECGKTFIQCSHFTEPENIDTGEKPY
  KCQECNNVIKTCSVLTKNRIYAGGEHYRCEEFGKVFNQCSHLTEHEHGTEEKPCKYEECS
  SVFISCSSLSNQQMILAGEKLSKCETWYKGFNHSPNPSKHQRNEIGGKPFKCEECDSIFK
  WFSDLTKHKRIHTGEKPYKCDECGKAYTQSSHLSEHRRIHTGEKPYQCEECGKVFRTCSS
  LSNHKRTHSEEKPYTCEECGNIFKQLSDLTKHKKTHTGEKPYKCDECGKNFTQSSNLIVH
  KRIHTGEKPYKCEECGRVFMWFSDITKHKKTHTGEKPYKCDECGKNFTQSSNLIVHKRIH
  TGEKPYKCEKCGKAFTQFSHLTVHESIHT

• Sequence length: 629

Pathways

Reactome Pathway:

Generic Transcription Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Lymphoma, T-Cell, Cutaneous	Lymphoma	BEFREE	17979976		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24817947		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	24817947	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	24817947		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for ZNF195.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ZNF195.